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Gene set: PANCREAS_CHR1_AGUIRRE (C2:CLIN:0004)
Standard namePANCREAS_CHR1_AGUIRRE
Systematic nameC2:CLIN:0004
Brief descriptionGenes on chromosome 1 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma.
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

31 genes, 35 accessions (Toggle view)

AccessionGeneTitleLinks
212172_atAK2adenylate kinase 2Source|GeneCards
202838_atFUCA1fucosidase, alpha-L- 1, tissueSource|GeneCards
218882_s_atWDR3WD repeat domain 3Source|GeneCards
202528_atGALEUDP-galactose-4-epimeraseSource|GeneCards
218895_atGPATC3G patch domain containing 3Source|GeneCards
207042_atE2F2E2F transcription factor 2Source|GeneCards
201559_s_atCLIC4chloride intracellular channel 4Source|GeneCards
217812_atYTHDF2YTH domain family, member 2Source|GeneCards
218664_atMECRmitochondrial trans-2-enoyl-CoA reductaseSource|GeneCards
212348_s_atAOF2amine oxidase (flavin containing) domain 2Source|GeneCards
209463_s_atTAF12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDaSource|GeneCards
202772_atHMGCL3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)Source|GeneCards
202292_x_atLYPLA2 /// LYPLA2P1lysophospholipase II /// lysophospholipase II pseudogene 1 /// similar to Acyl-protein thioesterase 2 (Lysophospholipase II) (LPL-I)Source|GeneCards
208668_x_atHMGN2high-mobility group nucleosomal binding domain 2Source|GeneCards
213038_atIBRDC3IBR domain containing 3Source|GeneCards
219238_atPIGVphosphatidylinositol glycan, class VSource|GeneCards
200919_atPHC2polyhomeotic-like 2 (Drosophila)Source|GeneCards
215566_x_atLYPLA2lysophospholipase IISource|GeneCards
204175_atZNF593zinc finger protein 593Source|GeneCards
51146_atPIGVphosphatidylinositol glycan, class VSource|GeneCards
201696_atSFRS4splicing factor, arginine/serine-rich 4Source|GeneCards
221881_s_atCLIC4chloride intracellular channel 4Source|GeneCards
215568_x_atLYPLA2Lysophospholipase IISource|GeneCards
203379_atRPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 1Source|GeneCards
219438_atFLJ12650hypothetical protein FLJ12650Source|GeneCards
209006_s_atC1ORF63chromosome 1 open reading frame 63Source|GeneCards
201560_atCLIC4chloride intracellular channel 4Source|GeneCards
215783_s_atALPLalkaline phosphatase, liver/bone/kidneySource|GeneCards
212048_s_atYARStyrosyl-tRNA synthetaseSource|GeneCards
204407_atTTF2transcription termination factor, RNA polymerase IISource|GeneCards
201173_x_atNUDCnuclear distribution gene C homolog (A. nidulans)Source|GeneCards
218977_s_atSECP43tRNA selenocysteine associated proteinSource|GeneCards
220938_s_atGMEB1glucocorticoid modulatory element binding protein 1Source|GeneCards
200783_s_atSTMN1stathmin 1/oncoprotein 18Source|GeneCards
201225_s_atSRRM1serine/arginine repetitive matrix 1Source|GeneCards

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