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Gene set: PANCREAS_CHR7_AGUIRRE (C2:CLIN:0006)
Standard namePANCREAS_CHR7_AGUIRRE
Systematic nameC2:CLIN:0006
Brief descriptionGenes on chromosome 7 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma. 
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

47 genes, 62 accessions (Toggle view)

AccessionGeneTitleLinks
215458_s_atSMURF1SMAD specific E3 ubiquitin protein ligase 1Source|GeneCards
205960_atPDK4pyruvate dehydrogenase kinase, isoenzyme 4Source|GeneCards
215667_x_atPMS2L1 /// PMS2L2 //o PMS2 postmeiotic segregation increased 2 (S. cerevisiae) /// similar to postmeiotic segregation increased 2-like 2 /// postmeiotic segregation increased 2-like 11 /// similar to postmeiotic segregation increased 2-like 2 /// similar to PMS4 homolog mismatch repair protein - humanSource|GeneCards
205765_atCYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Source|GeneCards
211829_s_atGPR30G protein-coupled receptor 30Source|GeneCards
213474_atKCTD7Potassium channel tetramerisation domain containing 7Source|GeneCards
202185_atPLOD3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3Source|GeneCards
206529_x_atSLC26A4solute carrier family 26, member 4Source|GeneCards
202642_s_atTRRAPtransformation/transcription domain-associated proteinSource|GeneCards
208693_s_atGARSglycyl-tRNA synthetaseSource|GeneCards
212668_atSMURF1SMAD specific E3 ubiquitin protein ligase 1Source|GeneCards
204608_atASLargininosuccinate lyaseSource|GeneCards
203775_atSLC25A13solute carrier family 25, member 13 (citrin)Source|GeneCards
200852_x_atGNB2guanine nucleotide binding protein (G protein), beta polypeptide 2Source|GeneCards
220371_s_atSLC12A9solute carrier family 12 (potassium/chloride transporters), member 9Source|GeneCards
210830_s_atPON2paraoxonase 2Source|GeneCards
221660_atMYLC2PLmyosin light chain 2, precursor lymphocyte-specificSource|GeneCards
212706_atRASA4 /// FLJ21767RAS p21 protein activator 4 /// hypothetical protein FLJ21767Source|GeneCards
217499_x_atOR7E37Polfactory receptor, family 7, subfamily E, member 37 pseudogeneSource|GeneCards
202710_atBET1BET1 homolog (S. cerevisiae)Source|GeneCards
202276_atSHFM1split hand/foot malformation (ectrodactyly) type 1Source|GeneCards
219332_atMICAL-L2MICAL-like 2Source|GeneCards
203731_s_atZFP95zinc finger protein 95 homolog (mouse)Source|GeneCards
218034_atTTC11tetratricopeptide repeat domain 11Source|GeneCards
218981_atACN9ACN9 homolog (S. cerevisiae)Source|GeneCards
204857_atMAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)Source|GeneCards
203730_s_atZFP95zinc finger protein 95 homolog (mouse)Source|GeneCards
209095_atDLDx)Source|GeneCards
218008_atFLJ10099hypothetical protein FLJ10099Source|GeneCards
203572_s_atTAF6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDaSource|GeneCards
214342_atATXN7L1 /// ATXN7L4ataxin 7-like 1 /// ataxin 7-like 4Source|GeneCards
206223_atLMTK2lemur tyrosine kinase 2Source|GeneCards
213695_atPON3paraoxonase 3Source|GeneCards
215589_atSMURF1SMAD specific E3 ubiquitin protein ligase 1Source|GeneCards
214234_s_atCYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Source|GeneCards
220018_atCBLL1Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1Source|GeneCards
201541_s_atZNHIT1zinc finger, HIT domain containing 1Source|GeneCards
212212_s_atDKFZP586J0619DKFZP586J0619 proteinSource|GeneCards
201876_atPON2paraoxonase 2Source|GeneCards
218310_atRABGEF1RAB guanine nucleotide exchange factor (GEF) 1Source|GeneCards
206750_atMAFKv-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)Source|GeneCards
201259_s_atSYPL1synaptophysin-like 1Source|GeneCards
212666_atSMURF1SMAD specific E3 ubiquitin protein ligase 1Source|GeneCards
220692_atHSPC047HSPC047 proteinSource|GeneCards
214908_s_atTRRAPtransformation/transcription domain-associated proteinSource|GeneCards
208534_s_atRASA4 /// FLJ21767RAS p21 protein activator 4 /// hypothetical protein FLJ21767Source|GeneCards
214343_s_atATXN7L1 /// ATXN7L4ataxin 7-like 1 /// ataxin 7-like 4Source|GeneCards
221659_s_atMYLC2PLmyosin light chain 2, precursor lymphocyte-specificSource|GeneCards
203899_s_atRCP9calcitonin gene-related peptide-receptor component proteinSource|GeneCards
214235_atCYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Source|GeneCards
205003_atDOCK4dedicator of cytokinesis 4Source|GeneCards
203898_atRCP9calcitonin gene-related peptide-receptor component proteinSource|GeneCards
205047_s_atASNSasparagine synthetaseSource|GeneCards
218811_atC7ORF19chromosome 7 open reading frame 19Source|GeneCards
210640_s_atGPR30G protein-coupled receptor 30Source|GeneCards
219342_atCAS1O-acetyltransferaseSource|GeneCards
215457_atARPC1AActin related protein 2/3 complex, subunit 1A, 41kDaSource|GeneCards
209837_atAP4M1adaptor-related protein complex 4, mu 1 subunitSource|GeneCards
200950_atARPC1Aactin related protein 2/3 complex, subunit 1A, 41kDaSource|GeneCards
212707_s_atRASA4 /// FLJ21767RAS p21 protein activator 4 /// hypothetical protein FLJ21767Source|GeneCards
214740_atMGC13098 /// POLR2J2hypothetical protein MGC13098 /// DNA directed RNA polymerase II polypeptide J-related gene /// RPB11b2alpha proteinSource|GeneCards
201954_atARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDaSource|GeneCards


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