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Gene set: PANCREAS_CHR8_AGUIRRE (C2:CLIN:0007)
Standard namePANCREAS_CHR8_AGUIRRE
Systematic nameC2:CLIN:0007
Brief descriptionGenes on chromosome 8 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma.
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

58 genes, 81 accessions (Toggle view)

AccessionGeneTitleLinks
218500_atLOC51337mesenchymal stem cell protein DSCD75Source|GeneCards
219060_atC8ORF32chromosome 8 open reading frame 32Source|GeneCards
206432_atHAS2hyaluronan synthase 2Source|GeneCards
206237_s_atNRG1neuregulin 1Source|GeneCards
91684_g_atEXOSC4exosome component 4Source|GeneCards
203941_atRC74related to CPSF subunits 74 kDaSource|GeneCards
65718_atGPR124G protein-coupled receptor 124Source|GeneCards
218049_s_atMRPL13mitochondrial ribosomal protein L13Source|GeneCards
208323_s_atANXA13annexin A13Source|GeneCards
209487_atRBPMSRNA binding protein with multiple splicingSource|GeneCards
202594_atLEPROTL1leptin receptor overlapping transcript-like 1Source|GeneCards
219124_atC8ORF41chromosome 8 open reading frame 41Source|GeneCards
219606_atPHF20L1PHD finger protein 20-like 1Source|GeneCards
201089_atATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2Source|GeneCards
207836_s_atRBPMSRNA binding protein with multiple splicingSource|GeneCards
222155_s_atGPR172AG protein-coupled receptor 172ASource|GeneCards
209384_atPROSCproline synthetase co-transcribed homolog (bacterial)Source|GeneCards
213445_atZC3H3zinc finger CCCH-type containing 3Source|GeneCards
206188_atZNF623zinc finger protein 623Source|GeneCards
202595_s_atLEPROTL1leptin receptor overlapping transcript-like 1Source|GeneCards
216416_atNA
209510_atRNF139ring finger protein 139Source|GeneCards
201066_atCYC1cytochrome c-1Source|GeneCards
203261_atDCTN6dynactin 6Source|GeneCards
203355_s_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
201638_s_atCPSF1cleavage and polyadenylation specific factor 1, 160kDaSource|GeneCards
209517_s_atASH2Lash2 (absent, small, or homeotic)-like (Drosophila)Source|GeneCards
203669_s_atDGAT1diacylglycerol O-acyltransferase homolog 1 (mouse)Source|GeneCards
209385_s_atPROSCproline synthetase co-transcribed homolog (bacterial)Source|GeneCards
214394_x_atNA
91682_atNA
211051_s_atEXTL3exostoses (multiple)-like 3 /// exostoses (multiple)-like 3Source|GeneCards
218613_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
203534_atLSM1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)Source|GeneCards
209202_s_atEXTL3exostoses (multiple)-like 3Source|GeneCards
219071_x_atLOC51236brain protein 16Source|GeneCards
215983_s_atD8S2298Ereproduction 8Source|GeneCards
201985_atKIAA0196KIAA0196Source|GeneCards
211686_s_atRBM13RNA binding motif protein 13 /// RNA binding motif protein 13Source|GeneCards
216240_atNA
211060_x_atGPAA1GPAA1P anchor attachment protein 1 homolog (yeast) /// GPAA1P anchor attachment protein 1 homolog (yeast)Source|GeneCards
201375_s_atPPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformSource|GeneCards
202431_s_atMYCv-myc myelocytomatosis viral oncogene homolog (avian)Source|GeneCards
216249_atPVT1Pvt1 oncogene homolog, MYC activator (mouse)Source|GeneCards
208820_atPTK2PTK2 protein tyrosine kinase 2Source|GeneCards
218679_s_atVPS28vacuolar protein sorting 28 (yeast)Source|GeneCards
207837_atRBPMSRNA binding protein with multiple splicingSource|GeneCards
209523_atTAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDaSource|GeneCards
219402_s_atDERL1Der1-like domain family, member 1Source|GeneCards
212556_atSCRIBscribbled homolog (Drosophila)Source|GeneCards
218151_x_atGPR172AG protein-coupled receptor 172ASource|GeneCards
218172_s_atDERL1Der1-like domain family, member 1Source|GeneCards
200847_s_atTMEM66transmembrane protein 66Source|GeneCards
215690_x_atGPAA1GPAA1P anchor attachment protein 1 homolog (yeast)Source|GeneCards
214440_atNAT1N-acetyltransferase 1 (arylamine N-acetyltransferase)Source|GeneCards
201639_s_atCPSF1cleavage and polyadenylation specific factor 1, 160kDaSource|GeneCards
221814_atGPR124G protein-coupled receptor 124Source|GeneCards
218154_atGSDMDC1gasdermin domain containing 1Source|GeneCards
220973_s_atSHARPINshank-interacting protein-like 1 /// shank-interacting protein-like 1Source|GeneCards
219215_s_atSLC39A4solute carrier family 39 (zinc transporter), member 4Source|GeneCards
222025_s_atOPLAH5-oxoprolinase (ATP-hydrolysing)Source|GeneCards
218954_s_atBRF2BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-likeSource|GeneCards
58696_atEXOSC4exosome component 4Source|GeneCards
213681_atCYHR1cysteine/histidine-rich 1Source|GeneCards
201618_x_atGPAA1GPAA1P anchor attachment protein 1 homolog (yeast)Source|GeneCards
201374_x_atPPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformSource|GeneCards
36936_atTSTA3tissue specific transplantation antigen P35BSource|GeneCards
201644_atTSTA3tissue specific transplantation antigen P35BSource|GeneCards
218173_s_atWHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 1Source|GeneCards
214545_s_atPROSCproline synthetase co-transcribed homolog (bacterial)Source|GeneCards
217916_s_atFAM49Bfamily with sequence similarity 49, member BSource|GeneCards
218955_atBRF2BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-likeSource|GeneCards
218695_atEXOSC4exosome component 4Source|GeneCards
214061_atWDR67WD repeat domain 67Source|GeneCards
221543_s_atSPFH2SPFH domain family, member 2Source|GeneCards
203354_s_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
212690_atDDHD2DDHD domain containing 2Source|GeneCards
202680_atGTF2E2general transcription factor IIE, polypeptide 2, beta 34kDaSource|GeneCards
205770_atGSRglutathione reductaseSource|GeneCards
200632_s_atNDRG1N-myc downstream regulated gene 1Source|GeneCards
219624_atBAG4BCL2-associated athanogene 4Source|GeneCards

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