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Gene set: PANCREAS_CHR9_AGUIRRE (C2:CLIN:0008)
Standard namePANCREAS_CHR9_AGUIRRE
Systematic nameC2:CLIN:0008
Brief descriptionGenes on chromosome 9 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma. 
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

24 genes, 42 accessions (Toggle view)

AccessionGeneTitleLinks
211467_s_atNFIBnuclear factor I/BSource|GeneCards
200081_s_atRPS6ribosomal protein S6 /// ribosomal protein S6Source|GeneCards
214066_x_atNPR2natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)Source|GeneCards
209337_atPSIP1PC4 and SFRS1 interacting protein 1Source|GeneCards
216295_s_atCLTAclathrin, light polypeptide (Lca)Source|GeneCards
210758_atPSIP1PC4 and SFRS1 interacting protein 1Source|GeneCards
203712_atKIAA0020KIAA0020Source|GeneCards
204083_s_atTPM2tropomyosin 2 (beta)Source|GeneCards
204956_atMTAPmethylthioadenosine phosphorylaseSource|GeneCards
200960_x_atCLTAclathrin, light polypeptide (Lca)Source|GeneCards
207039_atCDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)Source|GeneCards
218503_atKIAA1797KIAA1797Source|GeneCards
209822_s_atVLDLRvery low density lipoprotein receptorSource|GeneCards
220049_s_atPDCD1LG2programmed cell death 1 ligand 2Source|GeneCards
209644_x_atCDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)Source|GeneCards
209134_s_atRPS6ribosomal protein S6Source|GeneCards
201254_x_atRPS6ribosomal protein S6Source|GeneCards
218528_s_atRNF38ring finger protein 38Source|GeneCards
218602_s_atFAM29Afamily with sequence similarity 29, member ASource|GeneCards
203169_atNA
213032_atNFIBNuclear factor I/BSource|GeneCards
206544_x_atSMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
209432_s_atCREB3cAMP responsive element binding protein 3Source|GeneCards
201628_s_atRRAGARas-related GTP binding ASource|GeneCards
211363_s_atMTAPmethylthioadenosine phosphorylaseSource|GeneCards
203254_s_atTLN1talin 1Source|GeneCards
212257_s_atSMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
213117_atKLHL9kelch-like 9 (Drosophila)Source|GeneCards
204050_s_atCLTAclathrin, light polypeptide (Lca)Source|GeneCards
209290_s_atNFIBnuclear factor I/BSource|GeneCards
213233_s_atKLHL9kelch-like 9 (Drosophila)Source|GeneCards
206815_atSPAG8sperm associated antigen 8Source|GeneCards
213029_atNFIBNuclear factor I/BSource|GeneCards
216685_s_atMTAPmethylthioadenosine phosphorylaseSource|GeneCards
218992_atC9ORF46chromosome 9 open reading frame 46Source|GeneCards
213019_atRANBP6RAN binding protein 6Source|GeneCards
207839_s_atC9ORF127chromosome 9 open reading frame 127Source|GeneCards
212654_atTPM2tropomyosin 2 (beta)Source|GeneCards
209289_atNFIBNuclear factor I/BSource|GeneCards
216293_atCLTAClathrin, light polypeptide (Lca)Source|GeneCards
204001_atSNAPC3small nuclear RNA activating complex, polypeptide 3, 50kDaSource|GeneCards
210465_s_atSNAPC3small nuclear RNA activating complex, polypeptide 3, 50kDaSource|GeneCards


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