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Gene set: BRENTANI_DEATH (C2:EXCU:0009)
Standard nameBRENTANI_DEATH
Systematic nameC2:EXCU:0009
Brief descriptionCancer related genes involved in cell death
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

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Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
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Genes

76 genes, 76 accessions (Toggle view)

GeneTitleLinks
BIKBCL2-interacting killer (apoptosis-inducing)Source|GeneCards
TNFRSF10Dtumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domainSource|GeneCards
CASP1caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)Source|GeneCards
DAPK1death-associated protein kinase 1Source|GeneCards
TRAF3TNF receptor-associated factor 3Source|GeneCards
CASP6caspase 6, apoptosis-related cysteine proteaseSource|GeneCards
CRADDCASP2 and RIPK1 domain containing adaptor with death domainSource|GeneCards
IL17interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)Source|GeneCards
CASP7caspase 7, apoptosis-related cysteine proteaseSource|GeneCards
CASP3caspase 3, apoptosis-related cysteine proteaseSource|GeneCards
GMLGPI anchored molecule like proteinSource|GeneCards
BAG4BCL2-associated athanogene 4Source|GeneCards
CFLARCASP8 and FADD-like apoptosis regulatorSource|GeneCards
NME3non-metastatic cells 3, protein expressed inSource|GeneCards
TP53BP2tumor protein p53 binding protein, 2Source|GeneCards
MYCV-myc myelocytomatosis viral oncogene homolog (avian)Source|GeneCards
TNFRSF10Btumor necrosis factor receptor superfamily, member 10bSource|GeneCards
MXI1MAX interacting protein 1Source|GeneCards
TNFtumor necrosis factor (TNF superfamily, member 2)Source|GeneCards
TRAF2TNF receptor-associated factor 2Source|GeneCards
BCL2B-cell CLL/lymphoma 2Source|GeneCards
BCL2A1BCL2-related protein A1Source|GeneCards
TNFSF10tumor necrosis factor (ligand) superfamily, member 10Source|GeneCards
TFPTTCF3 (E2A) fusion partner (in childhood Leukemia)Source|GeneCards
BAK1BCL2-antagonist/killer 1Source|GeneCards
DPF2D4, zinc and double PHD fingers family 2Source|GeneCards
TP73tumor protein p73Source|GeneCards
MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
TP53tumor protein p53 (Li-Fraumeni syndrome)Source|GeneCards
LTBlymphotoxin beta (TNF superfamily, member 3)Source|GeneCards
TP73Ltumor protein p73-likeSource|GeneCards
DAXXdeath-associated protein 6Source|GeneCards
BCL2L1BCL2-like 1Source|GeneCards
BIDBH3 interacting domain death agonistSource|GeneCards
LTAlymphotoxin alpha (TNF superfamily, member 1)Source|GeneCards
HRKharakiri, BCL2 interacting protein (contains only BH3 domain)Source|GeneCards
CIDEAcell death-inducing DFFA-like effector aSource|GeneCards
CASP9caspase 9, apoptosis-related cysteine proteaseSource|GeneCards
MAXMAX proteinSource|GeneCards
BNIP2BCL2/adenovirus E1B 19kDa interacting protein 2Source|GeneCards
F2Rcoagulation factor II (thrombin) receptorSource|GeneCards
BFARbifunctional apoptosis regulatorSource|GeneCards
PAWRPRKC, apoptosis, WT1, regulatorSource|GeneCards
AATFapoptosis antagonizing transcription factorSource|GeneCards
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3Source|GeneCards
DAPK3death-associated protein kinase 3Source|GeneCards
DAP3death associated protein 3Source|GeneCards
EVI1Ecotropic viral integration site 1Source|GeneCards
BAXBCL2-associated X proteinSource|GeneCards
MYD88myeloid differentiation primary response gene (88)Source|GeneCards
CASP8caspase 8, apoptosis-related cysteine proteaseSource|GeneCards
BNIP1BCL2/adenovirus E1B 19kDa interacting protein 1Source|GeneCards
CASP10caspase 10, apoptosis-related cysteine proteaseSource|GeneCards
TNFSF7tumor necrosis factor (ligand) superfamily, member 7Source|GeneCards
CASP4caspase 4, apoptosis-related cysteine proteaseSource|GeneCards
TRADDTNFRSF1A-associated via death domainSource|GeneCards
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaSource|GeneCards
FADDFas (TNFRSF6)-associated via death domainSource|GeneCards
CASP5caspase 5, apoptosis-related cysteine proteaseSource|GeneCards
STK17Bserine/threonine kinase 17b (apoptosis-inducing)Source|GeneCards
TNFRSF9tumor necrosis factor receptor superfamily, member 9Source|GeneCards
DAPdeath-associated proteinSource|GeneCards
BADBCL2-antagonist of cell deathSource|GeneCards
BCL2L2BCL2-like 2Source|GeneCards
EMP1epithelial membrane protein 1Source|GeneCards
STK17Aserine/threonine kinase 17a (apoptosis-inducing)Source|GeneCards
TNFRSF10Atumor necrosis factor receptor superfamily, member 10aSource|GeneCards
CASP2caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2)Source|GeneCards
TNFRSF25tumor necrosis factor receptor superfamily, member 25Source|GeneCards
PLAGL1pleiomorphic adenoma gene-like 1Source|GeneCards
FOSL2FOS-like antigen 2Source|GeneCards
APAF1apoptotic protease activating factorSource|GeneCards


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