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Gene set: BRENTANI_IMMUNE_FUNCTION (C2:EXCU:0012)
Standard nameBRENTANI_IMMUNE_FUNCTION
Systematic nameC2:EXCU:0012
Brief descriptionCancer related genes involved in immune function
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

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Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
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Genes

54 genes, 54 accessions (Toggle view)

GeneTitleLinks
IL13interleukin 13Source|GeneCards
CD36CD36 antigen (collagen type I receptor, thrombospondin receptor)Source|GeneCards
CD33CD33 antigen (gp67)Source|GeneCards
IL4interleukin 4Source|GeneCards
MICAMHC class I polypeptide-related sequence ASource|GeneCards
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)Source|GeneCards
IL17interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)Source|GeneCards
CD68CD68 antigenSource|GeneCards
CD24CD24 antigen (small cell lung carcinoma cluster 4 antigen)Source|GeneCards
TFE3transcription factor binding to IGHM enhancer 3Source|GeneCards
FCGR2BFc fragment of IgG, low affinity IIb, receptor for (CD32)Source|GeneCards
IFNGinterferon, gammaSource|GeneCards
CD2CD2 antigen (p50), sheep red blood cell receptorSource|GeneCards
IL1Binterleukin 1, betaSource|GeneCards
IFNB1interferon, beta 1, fibroblastSource|GeneCards
CD48CD48 antigen (B-cell membrane protein)Source|GeneCards
CD37CD37 antigenSource|GeneCards
CD8ACD8 antigen, alpha polypeptide (p32)Source|GeneCards
GAGE4G antigen 4Source|GeneCards
LAG3lymphocyte-activation gene 3Source|GeneCards
IFNA1interferon, alpha 1Source|GeneCards
IL10interleukin 10Source|GeneCards
IL18R1interleukin 18 receptor 1Source|GeneCards
SLAMF1signaling lymphocytic activation molecule family member 1Source|GeneCards
CD19CD19 antigenSource|GeneCards
IL16interleukin 16 (lymphocyte chemoattractant factor)Source|GeneCards
CD53CD53 antigenSource|GeneCards
MAGED2melanoma antigen, family D, 2Source|GeneCards
CD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
NKTRnatural killer-tumor recognition sequenceSource|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
IL15interleukin 15Source|GeneCards
CD14CD14 antigenSource|GeneCards
IFNAR2interferon (alpha, beta and omega) receptor 2Source|GeneCards
CD1DCD1D antigen, d polypeptideSource|GeneCards
IFNGR1interferon gamma receptor 1Source|GeneCards
BAGEB melanoma antigenSource|GeneCards
CD47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)Source|GeneCards
CD59CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)Source|GeneCards
IL2RBinterleukin 2 receptor, betaSource|GeneCards
CD7CD7 antigen (p41)Source|GeneCards
IL12RB1interleukin 12 receptor, beta 1Source|GeneCards
CD72CD72 antigenSource|GeneCards
CD4CD4 antigen (p55)Source|GeneCards
BTKBruton agammaglobulinemia tyrosine kinaseSource|GeneCards
CD69CD69 antigen (p60, early T-cell activation antigen)Source|GeneCards
IFNAR1interferon (alpha, beta and omega) receptor 1Source|GeneCards
CD34CD34 antigenSource|GeneCards
CD9CD9 antigen (p24)Source|GeneCards
HLA-Cmajor histocompatibility complex, class I, CSource|GeneCards
CTAG2cancer/testis antigen 2Source|GeneCards
CD97CD97 antigenSource|GeneCards
CD22CD22 antigenSource|GeneCards


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