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Gene set: BRENTANI_PROTEIN_MODIFICATION (C2:EXCU:0013)
Standard nameBRENTANI_PROTEIN_MODIFICATION
Systematic nameC2:EXCU:0013
Brief descriptionCancer related genes involved in protein modification
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

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Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
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Genes

150 genes, 150 accessions (Toggle view)

GeneTitleLinks
PDK2pyruvate dehydrogenase kinase, isoenzyme 2Source|GeneCards
HDAC4histone deacetylase 4Source|GeneCards
PTPRCprotein tyrosine phosphatase, receptor type, CSource|GeneCards
PTPRMprotein tyrosine phosphatase, receptor type, MSource|GeneCards
PRKG1protein kinase, cGMP-dependent, type ISource|GeneCards
PRKACGprotein kinase, cAMP-dependent, catalytic, gammaSource|GeneCards
RYKRYK receptor-like tyrosine kinaseSource|GeneCards
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)Source|GeneCards
HCKhemopoietic cell kinaseSource|GeneCards
MMEMembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)Source|GeneCards
CTSDcathepsin D (lysosomal aspartyl protease)Source|GeneCards
PRKCZprotein kinase C, zetaSource|GeneCards
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 1Source|GeneCards
EP300E1A binding protein p300Source|GeneCards
PIM1pim-1 oncogeneSource|GeneCards
PDPK13-phosphoinositide dependent protein kinase-1Source|GeneCards
TESK1testis-specific kinase 1Source|GeneCards
PPP2R3Aprotein phosphatase 2 (formerly 2A), regulatory subunit B'', alphaSource|GeneCards
PTPRDprotein tyrosine phosphatase, receptor type, DSource|GeneCards
PTPN12protein tyrosine phosphatase, non-receptor type 12Source|GeneCards
ABL2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)Source|GeneCards
HDAC5histone deacetylase 5Source|GeneCards
BLKB lymphoid tyrosine kinaseSource|GeneCards
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptideSource|GeneCards
PTPN6protein tyrosine phosphatase, non-receptor type 6Source|GeneCards
PTPRFprotein tyrosine phosphatase, receptor type, FSource|GeneCards
HDAC6histone deacetylase 6Source|GeneCards
PTPRKprotein tyrosine phosphatase, receptor type, KSource|GeneCards
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
PPEF1protein phosphatase, EF hand calcium-binding domain 1Source|GeneCards
DUSP8dual specificity phosphatase 8Source|GeneCards
HPNhepsin (transmembrane protease, serine 1)Source|GeneCards
PTPN7protein tyrosine phosphatase, non-receptor type 7Source|GeneCards
TBCCtubulin-specific chaperone cSource|GeneCards
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isoformSource|GeneCards
PRKCB1protein kinase C, beta 1Source|GeneCards
LTKleukocyte tyrosine kinaseSource|GeneCards
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)Source|GeneCards
PTK9PTK9 protein tyrosine kinase 9Source|GeneCards
PPP2R5Aprotein phosphatase 2, regulatory subunit B (B56), alpha isoformSource|GeneCards
LIMK1LIM domain kinase 1Source|GeneCards
ACP5acid phosphatase 5, tartrate resistantSource|GeneCards
SIAT1sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)Source|GeneCards
PTP4A1protein tyrosine phosphatase type IVA, member 1Source|GeneCards
PTPN9protein tyrosine phosphatase, non-receptor type 9Source|GeneCards
RAGErenal tumor antigenSource|GeneCards
CSNK1Ecasein kinase 1, epsilonSource|GeneCards
USP4ubiquitin specific protease 4 (proto-oncogene)Source|GeneCards
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologSource|GeneCards
PTP4A2Protein tyrosine phosphatase type IVA, member 2Source|GeneCards
PRKCGprotein kinase C, gammaSource|GeneCards
STK11serine/threonine kinase 11 (Peutz-Jeghers syndrome)Source|GeneCards
CSNK2A2casein kinase 2, alpha prime polypeptideSource|GeneCards
USP6ubiquitin specific protease 6 (Tre-2 oncogene)Source|GeneCards
PPP2CAprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformSource|GeneCards
DUSP7dual specificity phosphatase 7Source|GeneCards
PAK2p21 (CDKN1A)-activated kinase 2Source|GeneCards
MATKmegakaryocyte-associated tyrosine kinaseSource|GeneCards
USP5ubiquitin specific protease 5 (isopeptidase T)Source|GeneCards
LIMK2LIM domain kinase 2Source|GeneCards
PRKCIprotein kinase C, iotaSource|GeneCards
PPM1Dprotein phosphatase 1D magnesium-dependent, delta isoformSource|GeneCards
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)Source|GeneCards
PTPN18protein tyrosine phosphatase, non-receptor type 18 (brain-derived)Source|GeneCards
FURINfurin (paired basic amino acid cleaving enzyme)Source|GeneCards
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1Source|GeneCards
LCKlymphocyte-specific protein tyrosine kinaseSource|GeneCards
CTSBcathepsin BSource|GeneCards
PPP4Cprotein phosphatase 4 (formerly X), catalytic subunitSource|GeneCards
RPS6KA2ribosomal protein S6 kinase, 90kDa, polypeptide 2Source|GeneCards
IL3RAinterleukin 3 receptor, alpha (low affinity)Source|GeneCards
FERfer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)Source|GeneCards
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologSource|GeneCards
DPP4dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)Source|GeneCards
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)Source|GeneCards
PTPRRprotein tyrosine phosphatase, receptor type, RSource|GeneCards
PRKACAProtein kinase, cAMP-dependent, catalytic, alphaSource|GeneCards
PRSS25protease, serine, 25Source|GeneCards
BMXBMX non-receptor tyrosine kinaseSource|GeneCards
PPP1R3Aprotein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle)Source|GeneCards
PRKDCprotein kinase, DNA-activated, catalytic polypeptideSource|GeneCards
ABL1v-abl Abelson murine leukemia viral oncogene homolog 1Source|GeneCards
PRKACBprotein kinase, cAMP-dependent, catalytic, betaSource|GeneCards
CHUKconserved helix-loop-helix ubiquitous kinaseSource|GeneCards
CUL1cullin 1Source|GeneCards
PRKCAprotein kinase C, alphaSource|GeneCards
PPP1CBprotein phosphatase 1, catalytic subunit, beta isoformSource|GeneCards
DUSP9dual specificity phosphatase 9Source|GeneCards
PHKG2phosphorylase kinase, gamma 2 (testis)Source|GeneCards
TMPRSS2transmembrane protease, serine 2Source|GeneCards
PAPSS13'-phosphoadenosine 5'-phosphosulfate synthase 1Source|GeneCards
VHLvon Hippel-Lindau syndromeSource|GeneCards
PRKAR1Bprotein kinase, cAMP-dependent, regulatory, type I, betaSource|GeneCards
DUSP5dual specificity phosphatase 5Source|GeneCards
DMPKdystrophia myotonica-protein kinaseSource|GeneCards
PPP2R4protein phosphatase 2A, regulatory subunit B' (PR 53)Source|GeneCards
PTK7PTK7 protein tyrosine kinase 7Source|GeneCards
PDK4pyruvate dehydrogenase kinase, isoenzyme 4Source|GeneCards
PTPN11protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)Source|GeneCards
CSNK2Bcasein kinase 2, beta polypeptideSource|GeneCards
PTPN4protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)Source|GeneCards
PPP2R1Bprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoformSource|GeneCards
PTPN2protein tyrosine phosphatase, non-receptor type 2Source|GeneCards
DUSP3dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)Source|GeneCards
PRKAR2Bprotein kinase, cAMP-dependent, regulatory, type II, betaSource|GeneCards
ELK3ELK3, ETS-domain protein (SRF accessory protein 2)Source|GeneCards
CUL2cullin 2Source|GeneCards
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1Source|GeneCards
UCHL3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)Source|GeneCards
PTPN1protein tyrosine phosphatase, non-receptor type 1Source|GeneCards
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)Source|GeneCards
ACPPacid phosphatase, prostateSource|GeneCards
CSNK1Dcasein kinase 1, deltaSource|GeneCards
PTPRGprotein tyrosine phosphatase, receptor type, GSource|GeneCards
PRKCQprotein kinase C, thetaSource|GeneCards
PPP3CAprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)Source|GeneCards
BCRbreakpoint cluster regionSource|GeneCards
PPP5Cprotein phosphatase 5, catalytic subunitSource|GeneCards
PPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)Source|GeneCards
DUSP4dual specificity phosphatase 4Source|GeneCards
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologSource|GeneCards
PTPRHprotein tyrosine phosphatase, receptor type, HSource|GeneCards
STK3serine/threonine kinase 3 (STE20 homolog, yeast)Source|GeneCards
ACP2acid phosphatase 2, lysosomalSource|GeneCards
PPP2R2Aprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoformSource|GeneCards
FESfeline sarcoma oncogeneSource|GeneCards
STK4serine/threonine kinase 4Source|GeneCards
PPP2R5Dprotein phosphatase 2, regulatory subunit B (B56), delta isoformSource|GeneCards
PPP6Cprotein phosphatase 6, catalytic subunitSource|GeneCards
PTPRBprotein tyrosine phosphatase, receptor type, BSource|GeneCards
ACP1acid phosphatase 1, solubleSource|GeneCards
ANPEPalanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)Source|GeneCards
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isoformSource|GeneCards
SKIV-ski sarcoma viral oncogene homolog (avian)Source|GeneCards
PTPRN2protein tyrosine phosphatase, receptor type, N polypeptide 2Source|GeneCards
PRKG2protein kinase, cGMP-dependent, type IISource|GeneCards
CSNK1A1casein kinase 1, alpha 1Source|GeneCards
PTPRNprotein tyrosine phosphatase, receptor type, NSource|GeneCards
PPP2R5Eprotein phosphatase 2, regulatory subunit B (B56), epsilon isoformSource|GeneCards
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Source|GeneCards
PTPRAprotein tyrosine phosphatase, receptor type, ASource|GeneCards
ELK1ELK1, member of ETS oncogene familySource|GeneCards
PTPN3protein tyrosine phosphatase, non-receptor type 3Source|GeneCards
PCAFp300/CBP-associated factorSource|GeneCards
PPP2R5Bprotein phosphatase 2, regulatory subunit B (B56), beta isoformSource|GeneCards
PHKA2phosphorylase kinase, alpha 2 (liver)Source|GeneCards


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