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Gene set: BRENTANI_TRANSCRIPTION_FACTORS (C2:EXCU:0016)
Standard nameBRENTANI_TRANSCRIPTION_FACTORS
Systematic nameC2:EXCU:0016
Brief descriptionCancer related genes that are also transcription factors
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

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Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
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Genes

71 genes, 71 accessions (Toggle view)

GeneTitleLinks
PPARAperoxisome proliferative activated receptor, alphaSource|GeneCards
HKR3GLI-Kruppel family member HKR3Source|GeneCards
EGR3early growth response 3Source|GeneCards
FOSL1FOS-like antigen 1Source|GeneCards
FLI1Friend leukemia virus integration 1Source|GeneCards
NME1non-metastatic cells 1, protein (NM23A) expressed inSource|GeneCards
RELAv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)Source|GeneCards
WT1Wilms tumor 1Source|GeneCards
PAX7paired box gene 7Source|GeneCards
ETV1ets variant gene 1Source|GeneCards
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 2Source|GeneCards
PBX1pre-B-cell leukemia transcription factor 1Source|GeneCards
IRF4interferon regulatory factor 4Source|GeneCards
EGR1early growth response 1Source|GeneCards
FOXD2forkhead box D2Source|GeneCards
AHRaryl hydrocarbon receptorSource|GeneCards
MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1Source|GeneCards
ZNFN1A1zinc finger protein, subfamily 1A, 1 (Ikaros)Source|GeneCards
MYCV-myc myelocytomatosis viral oncogene homolog (avian)Source|GeneCards
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
MYOD1myogenic factor 3Source|GeneCards
MYBv-myb myeloblastosis viral oncogene homolog (avian)Source|GeneCards
STAT5Bsignal transducer and activator of transcription 5BSource|GeneCards
JUNDjun D proto-oncogeneSource|GeneCards
CBFBcore-binding factor, beta subunitSource|GeneCards
STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
CHES1checkpoint suppressor 1Source|GeneCards
DPF2D4, zinc and double PHD fingers family 2Source|GeneCards
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
MLLT7myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7Source|GeneCards
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Source|GeneCards
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi1Source|GeneCards
RELBv-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)Source|GeneCards
PMLpromyelocytic leukemiaSource|GeneCards
GLI3GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)Source|GeneCards
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)Source|GeneCards
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)Source|GeneCards
BCL6B-cell CLL/lymphoma 6 (zinc finger protein 51)Source|GeneCards
STAT5Asignal transducer and activator of transcription 5ASource|GeneCards
JUNBjun B proto-oncogeneSource|GeneCards
FOSBFBJ murine osteosarcoma viral oncogene homolog BSource|GeneCards
RUNX1runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)Source|GeneCards
JUNv-jun sarcoma virus 17 oncogene homolog (avian)Source|GeneCards
ETV6ets variant gene 6 (TEL oncogene)Source|GeneCards
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)Source|GeneCards
AATFapoptosis antagonizing transcription factorSource|GeneCards
LMO1LIM domain only 1 (rhombotin 1)Source|GeneCards
PBX2Pre-B-cell leukemia transcription factor 2Source|GeneCards
CEBPACCAAT/enhancer binding protein (C/EBP), alphaSource|GeneCards
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)Source|GeneCards
ETV3ets variant gene 3Source|GeneCards
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)Source|GeneCards
FOXD1forkhead box D1Source|GeneCards
FOXF1forkhead box F1Source|GeneCards
RXRAretinoid X receptor, alphaSource|GeneCards
SRFserum response factor (c-fos serum response element-binding transcription factor)Source|GeneCards
GLI2GLI-Kruppel family member GLI2Source|GeneCards
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 3Source|GeneCards
TLX1T-cell leukemia, homeobox 1Source|GeneCards
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)Source|GeneCards
ATF1activating transcription factor 1Source|GeneCards
FOSv-fos FBJ murine osteosarcoma viral oncogene homologSource|GeneCards
EHFets homologous factorSource|GeneCards
LITAFlipopolysaccharide-induced TNF factorSource|GeneCards
FOSL2FOS-like antigen 2Source|GeneCards


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