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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: XINACTIVATED_GENES (C2:LREV:0001)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>XINACTIVATED_GENES</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:LREV:0001</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes that escape X inactivation</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>LREV: Review paper</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Although the process of X inactivation in mammalian cells silences
the majority of genes on the inactivated X chromosome, some genes
escape this chromosome-wide silencing. Genes that escape X inactivation
present a unique opportunity to study the process of silencing
and the mechanisms that protect some genes from being turned off.
In this review, we will discuss evolutionary aspects of escape
from X inactivation, in relation to the divergence of the sex
chromosomes. Molecular characteristics, expression, and epigenetic
modifications of genes that escape will be presented, including
their developmental regulation and the implications of chromatin
domains along the X chromosome in modeling the escape process.
</pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12900543' target='EXTERNAL'>12900543</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>P.H.S.,Models,Human,Support,Y Chromosome/genetics,Dosage Compensation (Genetics),Molecular,Gene Expression,Evolution,genetics,Genetic,Variation (Genetics),X Chromosome</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'><a href='http://www.broad.mit.edu' target='EXTERNAL'>Broad Institute</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='XINACTIVATED_GENES.grp'>grp</a>|<a href='XINACTIVATED_GENES.xml'>xml</a>|<a href='XINACTIVATED_GENES.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>21 genes, 21 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>STS</td><td>steroid sulfatase (microsomal), arylsulfatase C, isozyme S</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=STS' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?STS' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>USP9X</td><td>ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=USP9X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?USP9X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TBL1X</td><td>transducin (beta)-like 1X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TBL1X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TBL1X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GRPR</td><td>gastrin-releasing peptide receptor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GRPR' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GRPR' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ZFX</td><td>zinc finger protein, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ZFX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ZFX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PCTK1</td><td>PCTAIRE protein kinase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PCTK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PCTK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TMSB4X</td><td>thymosin, beta 4, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TMSB4X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TMSB4X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CA5B</td><td>carbonic anhydrase VB, mitochondrial</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CA5B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CA5B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>EIF1AX</td><td>eukaryotic translation initiation factor 1A, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EIF1AX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EIF1AX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RPS4X</td><td>ribosomal protein S4, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RPS4X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RPS4X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PIR</td><td>Pirin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PIR' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PIR' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ARSD</td><td>arylsulfatase D</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ARSD' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ARSD' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ATP6AP2</td><td>ATPase, H+ transporting, lysosomal accessory protein 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ATP6AP2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ATP6AP2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DDX3X</td><td>DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DDX3X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DDX3X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PRKX</td><td>protein kinase, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PRKX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PRKX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SMCX</td><td>Smcx homolog, X-linked (mouse)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SMCX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SMCX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>OFD1</td><td>oral-facial-digital syndrome 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=OFD1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?OFD1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>EIF2S3</td><td>eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EIF2S3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EIF2S3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>UTX</td><td>ubiquitously transcribed tetratricopeptide repeat gene, X chromosome</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=UTX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?UTX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>UBE1</td><td>ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=UBE1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?UBE1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>INE1</td><td>inactivation escape 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=INE1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?INE1' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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