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Gene set: BMYB_MORPHOLINO_UP_SHEPARD (C2:MODL:0004)
Standard nameBMYB_MORPHOLINO_UP_SHEPARD
Systematic nameC2:MODL:0004
Brief descriptionGenes upregulated in bmyb morpholino knockdown vs control in zebra fish
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

216 genes, 216 accessions (Toggle view)

GeneTitleLinks
HSBP1heat shock factor binding protein 1Source|GeneCards
FLJ21908hypothetical protein FLJ21908Source|GeneCards
PTD004hypothetical protein PTD004Source|GeneCards
KIAA0056KIAA0056 proteinSource|GeneCards
PRC1protein regulator of cytokinesis 1Source|GeneCards
IFI30interferon, gamma-inducible protein 30Source|GeneCards
MSI1musashi homolog 1 (Drosophila)Source|GeneCards
RASL11BRAS-like, family 11, member BSource|GeneCards
SOCS3suppressor of cytokine signaling 3Source|GeneCards
C9ORF58chromosome 9 open reading frame 58Source|GeneCards
ASAH3N-acylsphingosine amidohydrolase (alkaline ceramidase) 3Source|GeneCards
PLEKHB2pleckstrin homology domain containing, family B (evectins) member 2Source|GeneCards
LY75lymphocyte antigen 75Source|GeneCards
CGI-38brain specific proteinSource|GeneCards
MMP2matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Source|GeneCards
GPC4glypican 4Source|GeneCards
LOC55871COBW-like proteinSource|GeneCards
PSMD3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3Source|GeneCards
AK3Adenylate kinase 3-like 1Source|GeneCards
POLR1Cpolymerase (RNA) I polypeptide C, 30kDaSource|GeneCards
FLJ22578hypothetical protein FLJ22578Source|GeneCards
BRF1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)Source|GeneCards
KIAA0409KIAA0409 proteinSource|GeneCards
LOC57149hypothetical protein A-211C6.1Source|GeneCards
C21ORF33chromosome 21 open reading frame 33Source|GeneCards
CAMK1Gcalcium/calmodulin-dependent protein kinase IGSource|GeneCards
SFRS4splicing factor, arginine/serine-rich 4Source|GeneCards
DLGAP4discs, large (Drosophila) homolog-associated protein 4Source|GeneCards
PAPOLBpoly(A) polymerase beta (testis specific)Source|GeneCards
SESN3sestrin 3Source|GeneCards
CCNG1cyclin G1Source|GeneCards
MDS028uncharacterized hematopoietic stem/progenitor cells protein MDS028Source|GeneCards
CRABP2cellular retinoic acid binding protein 2Source|GeneCards
SPPL2BSPPL2bSource|GeneCards
MRPS18Bmitochondrial ribosomal protein S18BSource|GeneCards
GCSHglycine cleavage system protein H (aminomethyl carrier)Source|GeneCards
C6ORF203chromosome 6 open reading frame 203Source|GeneCards
SH3GLB2SH3-domain GRB2-like endophilin B2Source|GeneCards
RHBGRhesus blood group, B glycoproteinSource|GeneCards
MGC3123hypothetical protein MGC3123Source|GeneCards
VRK2vaccinia related kinase 2Source|GeneCards
C4Acomplement component 4ASource|GeneCards
FBXO32F-box only protein 32Source|GeneCards
PTP4A3protein tyrosine phosphatase type IVA, member 3Source|GeneCards
PTP4A2Protein tyrosine phosphatase type IVA, member 2Source|GeneCards
RPP14ribonuclease P (14kD)Source|GeneCards
RPS27ribosomal protein S27 (metallopanstimulin 1)Source|GeneCards
WWOXWW domain containing oxidoreductaseSource|GeneCards
ATP6V1C2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2Source|GeneCards
C11ORF8chromosome 11 open reading frame 8Source|GeneCards
ARG1arginase, liverSource|GeneCards
PNPOpyridoxine-5'-phosphate oxidaseSource|GeneCards
UCK1uridine-cytidine kinase 1Source|GeneCards
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-likeSource|GeneCards
HMGA1high mobility group AT-hook 1Source|GeneCards
KRT18keratin 18Source|GeneCards
TMPOthymopoietinSource|GeneCards
CICcapicua homolog (Drosophila)Source|GeneCards
MPP1membrane protein, palmitoylated 1, 55kDaSource|GeneCards
STIP1stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)Source|GeneCards
RAB3CRAB3C, member RAS oncogene familySource|GeneCards
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 3Source|GeneCards
MBPmyelin basic proteinSource|GeneCards
C21ORF59chromosome 21 open reading frame 59Source|GeneCards
BCDO2beta-carotene dioxygenase 2Source|GeneCards
LOC56926hypothetical protein from EUROIMAGE 2021883Source|GeneCards
SLC16A6solute carrier family 16 (monocarboxylic acid transporters), member 6Source|GeneCards
KRT2Akeratin 2A (epidermal ichthyosis bullosa of Siemens)Source|GeneCards
FOXI1forkhead box I1Source|GeneCards
DNAJA2DnaJ (Hsp40) homolog, subfamily A, member 2Source|GeneCards
MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
KNS2Kinesin 2Source|GeneCards
FXR1fragile X mental retardation, autosomal homolog 1Source|GeneCards
LOC283871hypothetical protein LOC283871Source|GeneCards
OSBPL10oxysterol binding protein-like 10Source|GeneCards
RDH10retinol dehydrogenase 10 (all-trans)Source|GeneCards
STARD3START domain containing 3Source|GeneCards
METAP1methionyl aminopeptidase 1Source|GeneCards
BMP2bone morphogenetic protein 2Source|GeneCards
MS4A4Amembrane-spanning 4-domains, subfamily A, member 4Source|GeneCards
EIF4Eeukaryotic translation initiation factor 4ESource|GeneCards
BAXBCL2-associated X proteinSource|GeneCards
HNF4Ahepatocyte nuclear factor 4, alphaSource|GeneCards
ATP1A1ATPase, Na+/K+ transporting, alpha 1 polypeptideSource|GeneCards
USP36ubiquitin specific protease 36Source|GeneCards
FOXO3Aforkhead box O3ASource|GeneCards
TRIM16tripartite motif-containing 16Source|GeneCards
SPUFsecreted protein of unknown functionSource|GeneCards
TRIM47tripartite motif-containing 47Source|GeneCards
CYP26B1cytochrome P450, family 26, subfamily B, polypeptide 1Source|GeneCards
VDAC3voltage-dependent anion channel 3Source|GeneCards
MRPL19mitochondrial ribosomal protein L19Source|GeneCards
PDCphosducinSource|GeneCards
GYGglycogeninSource|GeneCards
GMPRguanosine monophosphate reductaseSource|GeneCards
EFHD2EF-hand domain family, member D2Source|GeneCards
FOSv-fos FBJ murine osteosarcoma viral oncogene homologSource|GeneCards
LMAN2lectin, mannose-binding 2Source|GeneCards
IGF2insulin-like growth factor 2 (somatomedin A)Source|GeneCards
FABP1fatty acid binding protein 1, liverSource|GeneCards
JTV1JTV1 geneSource|GeneCards
FNTBfarnesyltransferase, CAAX box, betaSource|GeneCards
SIRT1sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)Source|GeneCards
SYBL1synaptobrevin-like 1Source|GeneCards
PRDX1peroxiredoxin 1Source|GeneCards
QKIquaking homolog, KH domain RNA binding (mouse)Source|GeneCards
NUDT9nudix (nucleoside diphosphate linked moiety X)-type motif 9Source|GeneCards
MINAMYC induced nuclear antigenSource|GeneCards
HSD3B1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1Source|GeneCards
ZNF330zinc finger protein 330Source|GeneCards
PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)Source|GeneCards
FLJ40873hypothetical protein FLJ40873Source|GeneCards
HRBHIV-1 Rev binding proteinSource|GeneCards
HFEhemochromatosisSource|GeneCards
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3Source|GeneCards
PTGES2prostaglandin E synthase 2Source|GeneCards
TIMP2tissue inhibitor of metalloproteinase 2Source|GeneCards
BGNbiglycanSource|GeneCards
TP53tumor protein p53 (Li-Fraumeni syndrome)Source|GeneCards
ABCC5ATP-binding cassette, sub-family C (CFTR/MRP), member 5Source|GeneCards
CCNG2cyclin G2Source|GeneCards
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Source|GeneCards
WHSC2Wolf-Hirschhorn syndrome candidate 2Source|GeneCards
TBX6T-box 6Source|GeneCards
LOC122618hypothetical protein BC015003Source|GeneCards
SLC31A1solute carrier family 31 (copper transporters), member 1Source|GeneCards
GNSglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)Source|GeneCards
LOC129881hypothetical LOC129881Source|GeneCards
CPNE3copine IIISource|GeneCards
ALG6asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase)Source|GeneCards
LOC56931hypothetical protein from EUROIMAGE 1967720Source|GeneCards
PHLDA2pleckstrin homology-like domain, family A, member 2Source|GeneCards
HM13histocompatibility (minor) 13Source|GeneCards
CUBNcubilin (intrinsic factor-cobalamin receptor)Source|GeneCards
LOC151963similar to BcDNA:GH11415 gene productSource|GeneCards
SNX27sorting nexin family member 27Source|GeneCards
SQSTM1sequestosome 1Source|GeneCards
PDE6Cphosphodiesterase 6C, cGMP-specific, cone, alpha primeSource|GeneCards
HSPCAheat shock 90kDa protein 1, alphaSource|GeneCards
ARRDC3arrestin domain containing 3Source|GeneCards
LOC90850hypothetical protein LOC90850Source|GeneCards
CASP8caspase 8, apoptosis-related cysteine proteaseSource|GeneCards
TP53INP1tumor protein p53 inducible nuclear protein 1Source|GeneCards
RPL10Lribosomal protein L10-likeSource|GeneCards
SSBSjogren syndrome antigen B (autoantigen La)Source|GeneCards
NAPE-PLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DSource|GeneCards
SDF2L1stromal cell-derived factor 2-like 1Source|GeneCards
C21ORF70chromosome 21 open reading frame 70Source|GeneCards
SASH1SAM and SH3 domain containing 1Source|GeneCards
CYP11A1cytochrome P450, family 11, subfamily A, polypeptide 1Source|GeneCards
MBD2methyl-CpG binding domain protein 2Source|GeneCards
ANXA2annexin A2Source|GeneCards
PSMF1proteasome (prosome, macropain) inhibitor subunit 1 (PI31)Source|GeneCards
OSGEPL1O-sialoglycoprotein endopeptidase-like 1Source|GeneCards
UPB1ureidopropionase, betaSource|GeneCards
DNAJB4DnaJ (Hsp40) homolog, subfamily B, member 4Source|GeneCards
FLJ37953hypothetical protein FLJ37953Source|GeneCards
SCARB1scavenger receptor class B, member 1Source|GeneCards
TPD52L2tumor protein D52-like 2Source|GeneCards
PRSS25protease, serine, 25Source|GeneCards
ENDOGL1endonuclease G-like 1Source|GeneCards
SLC25A28solute carrier family 25, member 28Source|GeneCards
HSPB1heat shock 27kDa protein 1Source|GeneCards
C10ORF63chromosome 10 open reading frame 63Source|GeneCards
SND1staphylococcal nuclease domain containing 1Source|GeneCards
NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
ABAT4-aminobutyrate aminotransferaseSource|GeneCards
SET7SET domain-containing protein 7Source|GeneCards
RAB36RAB36, member RAS oncogene familySource|GeneCards
LAMP2lysosomal-associated membrane protein 2Source|GeneCards
B2Mbeta-2-microglobulinSource|GeneCards
CPN1carboxypeptidase N, polypeptide 1, 50kDSource|GeneCards
LOC127253hypothetical protein BC009514Source|GeneCards
FSTfollistatinSource|GeneCards
GLUD1glutamate dehydrogenase 1Source|GeneCards
HPGDhydroxyprostaglandin dehydrogenase 15-(NAD)Source|GeneCards
PLAAphospholipase A2-activating proteinSource|GeneCards
C20ORF155chromosome 20 open reading frame 155Source|GeneCards
HNRPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)Source|GeneCards
WNT11wingless-type MMTV integration site family, member 11Source|GeneCards
RIOK3RIO kinase 3 (yeast)Source|GeneCards
IBRDC2IBR domain containing 2Source|GeneCards
LOC56965hypothetical protein from EUROIMAGE 1977056Source|GeneCards
HSU15552acidic 82 kDa protein mRNASource|GeneCards
PTPRNprotein tyrosine phosphatase, receptor type, NSource|GeneCards
HSPA2heat shock 70kDa protein 2Source|GeneCards
ITM2Bintegral membrane protein 2BSource|GeneCards


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