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Gene set: GENES_COMMON_BW_CB_MO_SHEPARD (C2:MODL:0005)
Standard nameGENES_COMMON_BW_CB_MO_SHEPARD
Systematic nameC2:MODL:0005
Brief descriptionGenes upregulated in both the crb mutant and bymb morpholino in zebra fish
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

79 genes, 79 accessions (Toggle view)

GeneTitleLinks
AURKBaurora kinase BSource|GeneCards
ASPMasp (abnormal spindle)-like, microcephaly associated (Drosophila)Source|GeneCards
GTSE1G-2 and S-phase expressed 1Source|GeneCards
HMGA1high mobility group AT-hook 1Source|GeneCards
PRC1protein regulator of cytokinesis 1Source|GeneCards
MGC49942hypothetical protein MGC49942Source|GeneCards
SFRP1secreted frizzled-related protein 1Source|GeneCards
FOXM1forkhead box M1Source|GeneCards
NR2F1nuclear receptor subfamily 2, group F, member 1Source|GeneCards
POU3F1POU domain, class 3, transcription factor 1Source|GeneCards
POU3F2POU domain, class 3, transcription factor 2Source|GeneCards
HLX1H2.0-like homeo box 1 (Drosophila)Source|GeneCards
RTKNrhotekinSource|GeneCards
POU3F3POU domain, class 3, transcription factor 3Source|GeneCards
DLG7discs, large homolog 7 (Drosophila)Source|GeneCards
TACC3transforming, acidic coiled-coil containing protein 3Source|GeneCards
CDCA3cell division cycle associated 3Source|GeneCards
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
KRT2Akeratin 2A (epidermal ichthyosis bullosa of Siemens)Source|GeneCards
CKAP2cytoskeleton associated protein 2Source|GeneCards
NUMA1nuclear mitotic apparatus protein 1Source|GeneCards
SOX21SRY (sex determining region Y)-box 21Source|GeneCards
TTNtitinSource|GeneCards
BMS1LBMS1-like, ribosome assembly protein (yeast)Source|GeneCards
KIF23kinesin family member 23Source|GeneCards
MKI67antigen identified by monoclonal antibody Ki-67Source|GeneCards
UCP2uncoupling protein 2 (mitochondrial, proton carrier)Source|GeneCards
FBXO5F-box only protein 5Source|GeneCards
ANLNanillin, actin binding protein (scraps homolog, Drosophila)Source|GeneCards
TNRC9trinucleotide repeat containing 9Source|GeneCards
MYH8myosin, heavy polypeptide 8, skeletal muscle, perinatalSource|GeneCards
FLJ12547hypothetical protein FLJ12547Source|GeneCards
KIF14kinesin family member 14Source|GeneCards
LHX1LIM homeobox 1Source|GeneCards
ASCL1achaete-scute complex-like 1 (Drosophila)Source|GeneCards
GRIK3glutamate receptor, ionotropic, kainate 3Source|GeneCards
ARID5BAT rich interactive domain 5B (MRF1-like)Source|GeneCards
TNXBtenascin XBSource|GeneCards
TPX2TPX2, microtubule-associated protein homolog (Xenopus laevis)Source|GeneCards
FGFR4fibroblast growth factor receptor 4Source|GeneCards
FLJ20641hypothetical protein FLJ20641Source|GeneCards
OTPorthopedia homolog (Drosophila)Source|GeneCards
SOX11SRY (sex determining region Y)-box 11Source|GeneCards
CTSLcathepsin LSource|GeneCards
GPSM1G-protein signalling modulator 1 (AGS3-like, C. elegans)Source|GeneCards
ATP1A1ATPase, Na+/K+ transporting, alpha 1 polypeptideSource|GeneCards
LOC55924hypothetical protein LOC55924Source|GeneCards
BIRC5baculoviral IAP repeat-containing 5 (survivin)Source|GeneCards
NOVA2neuro-oncological ventral antigen 2Source|GeneCards
CDCA2cell division cycle associated 2Source|GeneCards
TTKTTK protein kinaseSource|GeneCards
ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
PLP1proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)Source|GeneCards
CDC20CDC20 cell division cycle 20 homolog (S. cerevisiae)Source|GeneCards
HEY1hairy/enhancer-of-split related with YRPW motif 1Source|GeneCards
KIF11kinesin family member 11Source|GeneCards
TM7SF2transmembrane 7 superfamily member 2Source|GeneCards
PCDH18protocadherin 18Source|GeneCards
MASTLmicrotubule associated serine/threonine kinase-likeSource|GeneCards
NOTCH2Notch homolog 2 (Drosophila)Source|GeneCards
CCNB3cyclin B3Source|GeneCards
NDE1nudE nuclear distribution gene E homolog 1 (A. nidulans)Source|GeneCards
CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
MELKmaternal embryonic leucine zipper kinaseSource|GeneCards
EDG1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1Source|GeneCards
FLJ11029hypothetical protein FLJ11029Source|GeneCards
MT2Ametallothionein 2ASource|GeneCards
PTPRNprotein tyrosine phosphatase, receptor type, NSource|GeneCards
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)Source|GeneCards
CCNB1cyclin B1Source|GeneCards
TK1thymidine kinase 1, solubleSource|GeneCards
MDKmidkine (neurite growth-promoting factor 2)Source|GeneCards
GOLGB1golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1Source|GeneCards


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