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Gene set: MOUSE_ACOX1_UP (C2:MODL:0011)
Standard nameMOUSE_ACOX1_UP
Systematic nameC2:MODL:0011
Brief descriptionGenes up-regulated in hepatoma tissue in Acox1 KO mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers.
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

67 genes, 67 accessions (Toggle view)

GeneTitleLinks
CBR3carbonyl reductase 3Source|GeneCards
SLC16A1solute carrier family 16 (monocarboxylic acid transporters), member 1Source|GeneCards
RAD51L1RAD51-like 1 (S. cerevisiae)Source|GeneCards
ANXA2annexin A2Source|GeneCards
HOXC6homeo box C6Source|GeneCards
ANXA5annexin A5Source|GeneCards
APCSamyloid P component, serumSource|GeneCards
CTSEcathepsin ESource|GeneCards
EDN1endothelin 1Source|GeneCards
COL4A2collagen, type IV, alpha 2Source|GeneCards
LGALS3BPlectin, galactoside-binding, soluble, 3 binding proteinSource|GeneCards
CD24CD24 antigen (small cell lung carcinoma cluster 4 antigen)Source|GeneCards
HTATIP2HIV-1 Tat interactive protein 2, 30kDaSource|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
CD74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
KRT23keratin 23 (histone deacetylase inducible)Source|GeneCards
RPL12ribosomal protein L12Source|GeneCards
TBC1D8TBC1 domain family, member 8 (with GRAM domain)Source|GeneCards
SPRR1Asmall proline-rich protein 1ASource|GeneCards
GPX4glutathione peroxidase 4 (phospholipid hydroperoxidase)Source|GeneCards
FABP4fatty acid binding protein 4, adipocyteSource|GeneCards
VNN3vanin 3Source|GeneCards
KRT8keratin 8Source|GeneCards
IGFBP2insulin-like growth factor binding protein 2, 36kDaSource|GeneCards
PEX11Aperoxisomal biogenesis factor 11ASource|GeneCards
C1ORF24chromosome 1 open reading frame 24Source|GeneCards
SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3Source|GeneCards
RPL36ribosomal protein L36Source|GeneCards
ABHD2abhydrolase domain containing 2Source|GeneCards
IMPACThypothetical protein IMPACTSource|GeneCards
RAP1GA1RAP1, GTPase activating protein 1Source|GeneCards
GIPC2PDZ domain protein GIPC2Source|GeneCards
MFGE8milk fat globule-EGF factor 8 proteinSource|GeneCards
SLPIsecretory leukocyte protease inhibitor (antileukoproteinase)Source|GeneCards
TM4SF4transmembrane 4 superfamily member 4Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
CIDECcell death-inducing DFFA-like effector cSource|GeneCards
CTSLcathepsin LSource|GeneCards
HDAC1histone deacetylase 1Source|GeneCards
SLC20A1solute carrier family 20 (phosphate transporter), member 1Source|GeneCards
EHHADHenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenaseSource|GeneCards
HLA-DQA1 /// HLA-DQAmajor histocompatibility complex, class II, DQ alpha 1 /// major histocompatibility complex, class II, DQ alpha 2Source|GeneCards
NQO1NAD(P)H dehydrogenase, quinone 1Source|GeneCards
HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Source|GeneCards
CSTBcystatin B (stefin B)Source|GeneCards
SPON2spondin 2, extracellular matrix proteinSource|GeneCards
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
TAGLN2transgelin 2Source|GeneCards
CBR1carbonyl reductase 1Source|GeneCards
ADFPadipose differentiation-related proteinSource|GeneCards
FABP2fatty acid binding protein 2, intestinalSource|GeneCards
SGKserum/glucocorticoid regulated kinaseSource|GeneCards
TOXthymus high mobility group box protein TOXSource|GeneCards
NDRG1N-myc downstream regulated gene 1Source|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1Source|GeneCards
PALMDpalmdelphinSource|GeneCards
PLSCR1phospholipid scramblase 1Source|GeneCards
DEFB1defensin, beta 1Source|GeneCards
MT2Ametallothionein 2ASource|GeneCards
QPCTglutaminyl-peptide cyclotransferase (glutaminyl cyclase)Source|GeneCards
RGS2regulator of G-protein signalling 2, 24kDaSource|GeneCards
LPLlipoprotein lipaseSource|GeneCards
C1ORF24chromosome 1 open reading frame 24Source|GeneCards

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