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Gene set: MOUSE_DENA_UP (C2:MODL:0015)
Standard nameMOUSE_DENA_UP
Systematic nameC2:MODL:0015
Brief descriptionGenes up-regulated in hepatoma induced by diethylnitrosamine
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers.
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

60 genes, 60 accessions (Toggle view)

GeneTitleLinks
FBLN2fibulin 2Source|GeneCards
KDELR3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3Source|GeneCards
RAD51L1RAD51-like 1 (S. cerevisiae)Source|GeneCards
ANXA2annexin A2Source|GeneCards
APCSamyloid P component, serumSource|GeneCards
HOXC6homeo box C6Source|GeneCards
ANXA5annexin A5Source|GeneCards
COL4A2collagen, type IV, alpha 2Source|GeneCards
CD24CD24 antigen (small cell lung carcinoma cluster 4 antigen)Source|GeneCards
GPC3glypican 3Source|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
MCM6MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)Source|GeneCards
LGMNlegumainSource|GeneCards
TFF3trefoil factor 3 (intestinal)Source|GeneCards
LAMA5laminin, alpha 5Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
BCL2A1BCL2-related protein A1Source|GeneCards
TCTEL1t-complex-associated-testis-expressed 1-like 1Source|GeneCards
MMP12matrix metalloproteinase 12 (macrophage elastase)Source|GeneCards
FABP4fatty acid binding protein 4, adipocyteSource|GeneCards
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinSource|GeneCards
SPP1secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)Source|GeneCards
ANXA1annexin A1Source|GeneCards
VNN3vanin 3Source|GeneCards
SOX9SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)Source|GeneCards
B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6Source|GeneCards
RPL36ribosomal protein L36Source|GeneCards
PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)Source|GeneCards
ABHD2abhydrolase domain containing 2Source|GeneCards
MFGE8milk fat globule-EGF factor 8 proteinSource|GeneCards
TM4SF4transmembrane 4 superfamily member 4Source|GeneCards
NOTCH3Notch homolog 3 (Drosophila)Source|GeneCards
NKTRnatural killer-tumor recognition sequenceSource|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Source|GeneCards
TLR1toll-like receptor 1Source|GeneCards
VCAM1vascular cell adhesion molecule 1Source|GeneCards
LEPRleptin receptorSource|GeneCards
CSN3casein kappaSource|GeneCards
PTPREprotein tyrosine phosphatase, receptor type, ESource|GeneCards
TAGLN2transgelin 2Source|GeneCards
LY6Dlymphocyte antigen 6 complex, locus DSource|GeneCards
S100A9S100 calcium binding protein A9 (calgranulin B)Source|GeneCards
COL4A1collagen, type IV, alpha 1Source|GeneCards
COL4A5collagen, type IV, alpha 5 (Alport syndrome)Source|GeneCards
CPEcarboxypeptidase ESource|GeneCards
NDRG1N-myc downstream regulated gene 1Source|GeneCards
KIF11kinesin family member 11Source|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
KIFAP3kinesin-associated protein 3Source|GeneCards
CTSScathepsin SSource|GeneCards
ANKRD1ankyrin repeat domain 1 (cardiac muscle)Source|GeneCards
THBS1thrombospondin 1Source|GeneCards
POU2AF1POU domain, class 2, associating factor 1Source|GeneCards
NUP205nucleoporin 205kDaSource|GeneCards
RGS2regulator of G-protein signalling 2, 24kDaSource|GeneCards
PLEKpleckstrinSource|GeneCards
LPLlipoprotein lipaseSource|GeneCards
PEA15phosphoprotein enriched in astrocytes 15Source|GeneCards

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