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Gene set: MOUSE_MYC_UP (C2:MODL:0019)
Standard nameMOUSE_MYC_UP
Systematic nameC2:MODL:0019
Brief descriptionGenes up-regulated in hepatoma tissue of Myc transgenic mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers.
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
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Genes

54 genes, 54 accessions (Toggle view)

GeneTitleLinks
LR8LR8 proteinSource|GeneCards
RPL28ribosomal protein L28Source|GeneCards
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 1Source|GeneCards
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1Source|GeneCards
DCLRE1ADNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)Source|GeneCards
TPRtranslocated promoter region (to activated MET oncogene)Source|GeneCards
RPS24ribosomal protein S24Source|GeneCards
PDGFCplatelet derived growth factor CSource|GeneCards
CTSEcathepsin ESource|GeneCards
RNASE4ribonuclease, RNase A family, 4Source|GeneCards
HTATIP2HIV-1 Tat interactive protein 2, 30kDaSource|GeneCards
MCM6MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)Source|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
APRTadenine phosphoribosyltransferaseSource|GeneCards
KIF20Akinesin family member 20ASource|GeneCards
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)Source|GeneCards
SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)Source|GeneCards
CDCA3cell division cycle associated 3Source|GeneCards
CTGFconnective tissue growth factorSource|GeneCards
NUSAP1nucleolar and spindle associated protein 1Source|GeneCards
RPL12ribosomal protein L12Source|GeneCards
RPS16ribosomal protein S16Source|GeneCards
SLC22A1solute carrier family 22 (organic cation transporter), member 1Source|GeneCards
CISHcytokine inducible SH2-containing proteinSource|GeneCards
DMPKdystrophia myotonica-protein kinaseSource|GeneCards
CSRP2cysteine and glycine-rich protein 2Source|GeneCards
FDFT1farnesyl-diphosphate farnesyltransferase 1Source|GeneCards
RPL36ribosomal protein L36Source|GeneCards
CYR61cysteine-rich, angiogenic inducer, 61Source|GeneCards
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
RPL13Aribosomal protein L13aSource|GeneCards
SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Source|GeneCards
GSTM1glutathione S-transferase M1Source|GeneCards
IDH3Aisocitrate dehydrogenase 3 (NAD+) alphaSource|GeneCards
MGST3microsomal glutathione S-transferase 3Source|GeneCards
SLC1A4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4Source|GeneCards
HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)Source|GeneCards
GLULglutamate-ammonia ligase (glutamine synthase)Source|GeneCards
CSTBcystatin B (stefin B)Source|GeneCards
LY6Dlymphocyte antigen 6 complex, locus DSource|GeneCards
GSTM2glutathione S-transferase M2 (muscle)Source|GeneCards
ACTG1actin, gamma 1Source|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2Source|GeneCards
FBXO21F-box only protein 21Source|GeneCards
PALMDpalmdelphinSource|GeneCards
CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
RPLP2ribosomal protein, large P2Source|GeneCards
LECT2leukocyte cell-derived chemotaxin 2Source|GeneCards
RPL13A /// LOC283340L13a; 60S ribosomal protein L13a; 23 kD highly basic proteinSource|GeneCards
LPLlipoprotein lipaseSource|GeneCards
RPS14ribosomal protein S14Source|GeneCards
MAT2Amethionine adenosyltransferase II, alphaSource|GeneCards

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