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Gene set: ZF_CELL_PROLIF (C2:MODL:0008)
Standard nameZF_CELL_PROLIF
Systematic nameC2:MODL:0008
Brief descriptionCell proliferation genes determined in zebra fish
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

232 genes, 232 accessions (Toggle view)

GeneTitleLinks
CKS1BCDC28 protein kinase regulatory subunit 1BSource|GeneCards
CDK6cyclin-dependent kinase 6Source|GeneCards
CBFA2T2core-binding factor, runt domain, alpha subunit 2; translocated to, 2Source|GeneCards
TCF8transcription factor 8 (represses interleukin 2 expression)Source|GeneCards
CTNNBIP1catenin, beta interacting protein 1Source|GeneCards
C6ORF108chromosome 6 open reading frame 108Source|GeneCards
ISG20interferon stimulated gene 20kDaSource|GeneCards
REGLregenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat)Source|GeneCards
CDK9cyclin-dependent kinase 9 (CDC2-related kinase)Source|GeneCards
PIM2pim-2 oncogeneSource|GeneCards
VTI1Bvesicle transport through interaction with t-SNAREs homolog 1B (yeast)Source|GeneCards
GPC4glypican 4Source|GeneCards
BUB3BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)Source|GeneCards
CHRM1cholinergic receptor, muscarinic 1Source|GeneCards
MNTMAX binding proteinSource|GeneCards
CTF1cardiotrophin 1Source|GeneCards
CRIP1cysteine-rich protein 1 (intestinal)Source|GeneCards
ADRA1Badrenergic, alpha-1B-, receptorSource|GeneCards
RPS4Xribosomal protein S4, X-linkedSource|GeneCards
PDAP1PDGFA associated protein 1Source|GeneCards
ZNF187zinc finger protein 187Source|GeneCards
ERFEts2 repressor factorSource|GeneCards
CDC27cell division cycle 27Source|GeneCards
TACSTD2tumor-associated calcium signal transducer 2Source|GeneCards
EVI5ecotropic viral integration site 5Source|GeneCards
CHRM4cholinergic receptor, muscarinic 4Source|GeneCards
ERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
DTYMKdeoxythymidylate kinase (thymidylate kinase)Source|GeneCards
SYKspleen tyrosine kinaseSource|GeneCards
CYR61cysteine-rich, angiogenic inducer, 61Source|GeneCards
TXNthioredoxinSource|GeneCards
OSMRoncostatin M receptorSource|GeneCards
MS4A1membrane-spanning 4-domains, subfamily A, member 1Source|GeneCards
EMP3epithelial membrane protein 3Source|GeneCards
CHRM5cholinergic receptor, muscarinic 5Source|GeneCards
USP8ubiquitin specific protease 8Source|GeneCards
INSL4insulin-like 4 (placenta)Source|GeneCards
IL2RGinterleukin 2 receptor, gamma (severe combined immunodeficiency)Source|GeneCards
TCF19transcription factor 19 (SC1)Source|GeneCards
IL9Rinterleukin 9 receptorSource|GeneCards
PDCD1LG1programmed cell death 1 ligand 1Source|GeneCards
SKB1SKB1 homolog (S. pombe)Source|GeneCards
BTG1B-cell translocation gene 1, anti-proliferativeSource|GeneCards
KHDRBS1KH domain containing, RNA binding, signal transduction associated 1Source|GeneCards
RPP14ribonuclease P (14kD)Source|GeneCards
BST2bone marrow stromal cell antigen 2Source|GeneCards
BUB1BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)Source|GeneCards
UHRF1ubiquitin-like, containing PHD and RING finger domains, 1Source|GeneCards
RPS27ribosomal protein S27 (metallopanstimulin 1)Source|GeneCards
SIPA1signal-induced proliferation-associated gene 1Source|GeneCards
TGFAtransforming growth factor, alphaSource|GeneCards
ELNelastin (supravalvular aortic stenosis, Williams-Beuren syndrome)Source|GeneCards
EMP1epithelial membrane protein 1Source|GeneCards
SPOCKsparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)Source|GeneCards
TGFB2transforming growth factor, beta 2Source|GeneCards
CKS2CDC28 protein kinase regulatory subunit 2Source|GeneCards
METmet proto-oncogene (hepatocyte growth factor receptor)Source|GeneCards
ELF5E74-like factor 5 (ets domain transcription factor)Source|GeneCards
PYYpeptide YYSource|GeneCards
PTCHpatched homolog (Drosophila)Source|GeneCards
FSCN1fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)Source|GeneCards
ENPEPglutamyl aminopeptidase (aminopeptidase A)Source|GeneCards
RBBP7retinoblastoma binding protein 7Source|GeneCards
IRF2interferon regulatory factor 2Source|GeneCards
CDK7cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)Source|GeneCards
PRKCAprotein kinase C, alphaSource|GeneCards
STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
ARHGEF1Rho guanine nucleotide exchange factor (GEF) 1Source|GeneCards
BUB1BBUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)Source|GeneCards
EPS8epidermal growth factor receptor pathway substrate 8Source|GeneCards
MKI67antigen identified by monoclonal antibody Ki-67Source|GeneCards
KRT16keratin 16 (focal non-epidermolytic palmoplantar keratoderma)Source|GeneCards
CDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
EGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
TFDP1transcription factor Dp-1Source|GeneCards
LRPAP1low density lipoprotein receptor-related protein associated protein 1Source|GeneCards
IGFBP4insulin-like growth factor binding protein 4Source|GeneCards
CUL5cullin 5Source|GeneCards
TPX2TPX2, microtubule-associated protein homolog (Xenopus laevis)Source|GeneCards
FTH1ferritin, heavy polypeptide 1Source|GeneCards
IL1Ainterleukin 1, alphaSource|GeneCards
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)Source|GeneCards
CDK3cyclin-dependent kinase 3Source|GeneCards
EPHB4EphB4Source|GeneCards
CSF1colony stimulating factor 1 (macrophage)Source|GeneCards
CSE1LCSE1 chromosome segregation 1-like (yeast)Source|GeneCards
KIF2Ckinesin family member 2CSource|GeneCards
PRLprolactinSource|GeneCards
SERPINF1serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1Source|GeneCards
PDZK1PDZ domain containing 1Source|GeneCards
PRG4proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)Source|GeneCards
CDC2L2cell division cycle 2-like 2Source|GeneCards
PCNAproliferating cell nuclear antigenSource|GeneCards
IL3interleukin 3 (colony-stimulating factor, multiple)Source|GeneCards
FESfeline sarcoma oncogeneSource|GeneCards
TNFRSF9tumor necrosis factor receptor superfamily, member 9Source|GeneCards
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)Source|GeneCards
SFNstratifinSource|GeneCards
CDK4cyclin-dependent kinase 4Source|GeneCards
KNSL7kinesin-like 7Source|GeneCards
THPOthrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)Source|GeneCards
CDK5cyclin-dependent kinase 5Source|GeneCards
IL13interleukin 13Source|GeneCards
HDGFhepatoma-derived growth factor (high-mobility group protein 1-like)Source|GeneCards
PRDX1peroxiredoxin 1Source|GeneCards
GFI1Bgrowth factor independent 1B (potential regulator of CDKN1A, translocated in CML)Source|GeneCards
BLZF1basic leucine zipper nuclear factor 1 (JEM-1)Source|GeneCards
DUSP22dual specificity phosphatase 22Source|GeneCards
IL5RAinterleukin 5 receptor, alphaSource|GeneCards
CD81CD81 antigen (target of antiproliferative antibody 1)Source|GeneCards
MT3metallothionein 3 (growth inhibitory factor (neurotrophic))Source|GeneCards
CDC16CDC16 cell division cycle 16 homolog (S. cerevisiae)Source|GeneCards
MYCV-myc myelocytomatosis viral oncogene homolog (avian)Source|GeneCards
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Source|GeneCards
MAS1MAS1 oncogeneSource|GeneCards
NAB2NGFI-A binding protein 2 (EGR1 binding protein 2)Source|GeneCards
TM4SF1transmembrane 4 superfamily member 1Source|GeneCards
NUDCnuclear distribution gene C homolog (A. nidulans)Source|GeneCards
IL1Binterleukin 1, betaSource|GeneCards
FGF5fibroblast growth factor 5Source|GeneCards
LGI1leucine-rich, glioma inactivated 1Source|GeneCards
APRINandrogen-induced proliferation inhibitorSource|GeneCards
HDGFRP3hepatoma-derived growth factor, related protein 3Source|GeneCards
EDNRAendothelin receptor type ASource|GeneCards
IL6Rinterleukin 6 receptorSource|GeneCards
LAMA1laminin, alpha 1Source|GeneCards
CD160CD160 antigenSource|GeneCards
LRP1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)Source|GeneCards
FZD3frizzled homolog 3 (Drosophila)Source|GeneCards
GRPRgastrin-releasing peptide receptorSource|GeneCards
IL8RBinterleukin 8 receptor, betaSource|GeneCards
BCAR1breast cancer anti-estrogen resistance 1Source|GeneCards
GAB1GRB2-associated binding protein 1Source|GeneCards
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)Source|GeneCards
ZFP36L2zinc finger protein 36, C3H type-like 2Source|GeneCards
RFPRet finger proteinSource|GeneCards
OSMoncostatin MSource|GeneCards
AREGamphiregulin (schwannoma-derived growth factor)Source|GeneCards
BCAT1branched chain aminotransferase 1, cytosolicSource|GeneCards
GSPT1G1 to S phase transition 1Source|GeneCards
RAF1v-raf-1 murine leukemia viral oncogene homolog 1Source|GeneCards
PEMTphosphatidylethanolamine N-methyltransferaseSource|GeneCards
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)Source|GeneCards
MNAT1menage a trois 1 (CAK assembly factor)Source|GeneCards
S100A6S100 calcium binding protein A6 (calcyclin)Source|GeneCards
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)Source|GeneCards
TNFRSF17tumor necrosis factor receptor superfamily, member 17Source|GeneCards
APPLadaptor protein containing pH domain, PTB domain and leucine zipper motifSource|GeneCards
SLC29A2solute carrier family 29 (nucleoside transporters), member 2Source|GeneCards
IL11interleukin 11Source|GeneCards
GCGglucagonSource|GeneCards
EHFets homologous factorSource|GeneCards
PTHLHparathyroid hormone-like hormoneSource|GeneCards
MATKmegakaryocyte-associated tyrosine kinaseSource|GeneCards
IL6interleukin 6 (interferon, beta 2)Source|GeneCards
CD28CD28 antigen (Tp44)Source|GeneCards
PRDM4PR domain containing 4Source|GeneCards
TCFL5transcription factor-like 5 (basic helix-loop-helix)Source|GeneCards
PDGFRAplatelet-derived growth factor receptor, alpha polypeptideSource|GeneCards
HGFhepatocyte growth factor (hepapoietin A; scatter factor)Source|GeneCards
IL4interleukin 4Source|GeneCards
PSPHLphosphoserine phosphatase-likeSource|GeneCards
EMP2epithelial membrane protein 2Source|GeneCards
ZNF259zinc finger protein 259Source|GeneCards
SILTAL1 (SCL) interrupting locusSource|GeneCards
CLK1CDC-like kinase 1Source|GeneCards
TPD52L2tumor protein D52-like 2Source|GeneCards
NDPNorrie disease (pseudoglioma)Source|GeneCards
IL2RAinterleukin 2 receptor, alphaSource|GeneCards
BIN1bridging integrator 1Source|GeneCards
DKC1dyskeratosis congenita 1, dyskerinSource|GeneCards
REG1Bregenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)Source|GeneCards
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)Source|GeneCards
KITLGKIT ligandSource|GeneCards
TM4SF8transmembrane 4 superfamily member 8Source|GeneCards
GRNgranulinSource|GeneCards
TGFBItransforming growth factor, beta-induced, 68kDaSource|GeneCards
NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
TNFSF13Btumor necrosis factor (ligand) superfamily, member 13bSource|GeneCards
EPS15epidermal growth factor receptor pathway substrate 15Source|GeneCards
TAL1T-cell acute lymphocytic leukemia 1Source|GeneCards
MYT2myelin transcription factor 2Source|GeneCards
MTCP1mature T-cell proliferation 1Source|GeneCards
PLEKHC1pleckstrin homology domain containing, family C (with FERM domain) member 1Source|GeneCards
LAMP3lysosomal-associated membrane protein 3Source|GeneCards
S100BS100 calcium binding protein, beta (neural)Source|GeneCards
TNFSF8tumor necrosis factor (ligand) superfamily, member 8Source|GeneCards
IL15interleukin 15Source|GeneCards
PDGFAplatelet-derived growth factor alpha polypeptideSource|GeneCards
LMO1LIM domain only 1 (rhombotin 1)Source|GeneCards
CDC25Ccell division cycle 25CSource|GeneCards
NPYneuropeptide YSource|GeneCards
TNFSF9tumor necrosis factor (ligand) superfamily, member 9Source|GeneCards
MAPRE1microtubule-associated protein, RP/EB family, member 1Source|GeneCards
LY86lymphocyte antigen 86Source|GeneCards
SKP2S-phase kinase-associated protein 2 (p45)Source|GeneCards
MIAmelanoma inhibitory activitySource|GeneCards
UBE2V2ubiquitin-conjugating enzyme E2 variant 2Source|GeneCards
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Source|GeneCards
TM4SF9transmembrane 4 superfamily member 9Source|GeneCards
TNFSF7tumor necrosis factor (ligand) superfamily, member 7Source|GeneCards
MPLmyeloproliferative leukemia virus oncogeneSource|GeneCards
INSIG1insulin induced gene 1Source|GeneCards
E2F1E2F transcription factor 1Source|GeneCards
CCKBRcholecystokinin B receptorSource|GeneCards
IL15RAinterleukin 15 receptor, alphaSource|GeneCards
MAPRE2microtubule-associated protein, RP/EB family, member 2Source|GeneCards
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)Source|GeneCards
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)Source|GeneCards
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 3Source|GeneCards
CXORF15chromosome X open reading frame 15Source|GeneCards
E4F1E4F transcription factor 1Source|GeneCards
CSF1Rcolony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homologSource|GeneCards
DCTN2dynactin 2 (p50)Source|GeneCards
FGF6fibroblast growth factor 6Source|GeneCards
PTENphosphatase and tensin homolog (mutated in multiple advanced cancers 1)Source|GeneCards


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