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Gene set: ZF_NEG_REG_OF_CELL_PROLIF (C2:MODL:0007)
Standard nameZF_NEG_REG_OF_CELL_PROLIF
Systematic nameC2:MODL:0007
Brief descriptionNegative regulators of cell proliferation in zebra fish
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

116 genes, 116 accessions (Toggle view)

GeneTitleLinks
DLEC1deleted in lung and esophageal cancer 1Source|GeneCards
TP53I11tumor protein p53 inducible protein 11Source|GeneCards
CCL23chemokine (C-C motif) ligand 23Source|GeneCards
CD33CD33 antigen (gp67)Source|GeneCards
RARRES3retinoic acid receptor responder (tazarotene induced) 3Source|GeneCards
ATP8A2ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2Source|GeneCards
SSTR5somatostatin receptor 5Source|GeneCards
IGFBP7insulin-like growth factor binding protein 7Source|GeneCards
CHEK1CHK1 checkpoint homolog (S. pombe)Source|GeneCards
CDC6CDC6 cell division cycle 6 homolog (S. cerevisiae)Source|GeneCards
MNTMAX binding proteinSource|GeneCards
MUC12mucin 12Source|GeneCards
IL1Binterleukin 1, betaSource|GeneCards
APRINandrogen-induced proliferation inhibitorSource|GeneCards
COL18A1collagen, type XVIII, alpha 1Source|GeneCards
ADAMTS8a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8Source|GeneCards
CNOT8CCR4-NOT transcription complex, subunit 8Source|GeneCards
MXD4MAX dimerization protein 4Source|GeneCards
CTBP2C-terminal binding protein 2Source|GeneCards
EMP3epithelial membrane protein 3Source|GeneCards
CTBP1C-terminal binding protein 1Source|GeneCards
SSTR4somatostatin receptor 4Source|GeneCards
TM4SF4transmembrane 4 superfamily member 4Source|GeneCards
HGShepatocyte growth factor-regulated tyrosine kinase substrateSource|GeneCards
OSMoncostatin MSource|GeneCards
CDKN2Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)Source|GeneCards
PMP22peripheral myelin protein 22Source|GeneCards
WARStryptophanyl-tRNA synthetaseSource|GeneCards
ADRA1Aadrenergic, alpha-1A-, receptorSource|GeneCards
BTG1B-cell translocation gene 1, anti-proliferativeSource|GeneCards
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)Source|GeneCards
IL8interleukin 8Source|GeneCards
CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)Source|GeneCards
APEG1aortic preferentially expressed protein 1Source|GeneCards
CDK10cyclin-dependent kinase (CDC2-like) 10Source|GeneCards
CGREF1cell growth regulator with EF hand domain 1Source|GeneCards
LDOC1leucine zipper, down-regulated in cancer 1Source|GeneCards
GNRH1gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)Source|GeneCards
PTHLHparathyroid hormone-like hormoneSource|GeneCards
IL6interleukin 6 (interferon, beta 2)Source|GeneCards
PPM1Dprotein phosphatase 1D magnesium-dependent, delta isoformSource|GeneCards
QSCN6quiescin Q6Source|GeneCards
DLG5discs, large homolog 5 (Drosophila)Source|GeneCards
BTG2BTG family, member 2Source|GeneCards
S100A11S100 calcium binding protein A11 (calgizzarin)Source|GeneCards
BAP1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)Source|GeneCards
FRKfyn-related kinaseSource|GeneCards
BTG3BTG family, member 3Source|GeneCards
TOB1transducer of ERBB2, 1Source|GeneCards
GMLGPI anchored molecule like proteinSource|GeneCards
FABP7fatty acid binding protein 7, brainSource|GeneCards
TGFB1I1transforming growth factor beta 1 induced transcript 1Source|GeneCards
CDKN3cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)Source|GeneCards
SSTR2somatostatin receptor 2Source|GeneCards
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
MXI1MAX interacting protein 1Source|GeneCards
ZRANB1zinc finger, RAN-binding domain containing 1Source|GeneCards
BCL2B-cell CLL/lymphoma 2Source|GeneCards
CUL1cullin 1Source|GeneCards
UMODuromodulin (uromucoid, Tamm-Horsfall glycoprotein)Source|GeneCards
IGFBP6insulin-like growth factor binding protein 6Source|GeneCards
MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
VHLvon Hippel-Lindau syndromeSource|GeneCards
MLLT7myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7Source|GeneCards
BAI1brain-specific angiogenesis inhibitor 1Source|GeneCards
SSTR1somatostatin receptor 1Source|GeneCards
NF1neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)Source|GeneCards
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)Source|GeneCards
AIF1allograft inflammatory factor 1Source|GeneCards
RARRES1retinoic acid receptor responder (tazarotene induced) 1Source|GeneCards
ITM1integral membrane protein 1Source|GeneCards
FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)Source|GeneCards
NF2neurofibromin 2 (bilateral acoustic neuroma)Source|GeneCards
CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Source|GeneCards
CGRRF1cell growth regulator with ring finger domain 1Source|GeneCards
POU1F1POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)Source|GeneCards
SSTR3somatostatin receptor 3Source|GeneCards
SSTsomatostatinSource|GeneCards
OPRM1opioid receptor, mu 1Source|GeneCards
NDNnecdin homolog (mouse)Source|GeneCards
FABP6fatty acid binding protein 6, ileal (gastrotropin)Source|GeneCards
CUL5cullin 5Source|GeneCards
TNFRSF8tumor necrosis factor receptor superfamily, member 8Source|GeneCards
PAWRPRKC, apoptosis, WT1, regulatorSource|GeneCards
IL1Ainterleukin 1, alphaSource|GeneCards
CUL4Acullin 4ASource|GeneCards
CUL2cullin 2Source|GeneCards
TOB2transducer of ERBB2, 2Source|GeneCards
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)Source|GeneCards
C16ORF3chromosome 16 open reading frame 3Source|GeneCards
CD164CD164 antigen, sialomucinSource|GeneCards
GAS1growth arrest-specific 1Source|GeneCards
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activatorSource|GeneCards
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Source|GeneCards
PRKRIRprotein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)Source|GeneCards
RBBP4retinoblastoma binding protein 4Source|GeneCards
PLGplasminogenSource|GeneCards
CDKN2Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)Source|GeneCards
DRIMdown-regulated in metastasisSource|GeneCards
GPNMBglycoprotein (transmembrane) nmbSource|GeneCards
SIRPB2signal-regulatory protein beta 2Source|GeneCards
KLF4Kruppel-like factor 4 (gut)Source|GeneCards
CDC7CDC7 cell division cycle 7 (S. cerevisiae)Source|GeneCards
TNFRSF9tumor necrosis factor receptor superfamily, member 9Source|GeneCards
ING1inhibitor of growth family, member 1Source|GeneCards
SESN1sestrin 1Source|GeneCards
MDM4Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)Source|GeneCards
ADAMTS1a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1Source|GeneCards
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Source|GeneCards
NCK2NCK adaptor protein 2Source|GeneCards
PCAFp300/CBP-associated factorSource|GeneCards


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