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Gene set: ZF_POS_REG_OF_CELL_PROLIF (C2:MODL:0006)
Standard nameZF_POS_REG_OF_CELL_PROLIF
Systematic nameC2:MODL:0006
Brief descriptionPositive regulators of cell proliferation in zebra fish
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

108 genes, 108 accessions (Toggle view)

GeneTitleLinks
CDC2L5cell division cycle 2-like 5 (cholinesterase-related cell division controller)Source|GeneCards
IL9interleukin 9Source|GeneCards
FGAfibrinogen, A alpha polypeptideSource|GeneCards
SSR1signal sequence receptor, alpha (translocon-associated protein alpha)Source|GeneCards
TSHRthyroid stimulating hormone receptorSource|GeneCards
CAPN1calpain 1, (mu/I) large subunitSource|GeneCards
CXCL5chemokine (C-X-C motif) ligand 5Source|GeneCards
TIMP1tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)Source|GeneCards
MST1Rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)Source|GeneCards
CCL15chemokine (C-C motif) ligand 15Source|GeneCards
FGF7fibroblast growth factor 7 (keratinocyte growth factor)Source|GeneCards
FGBfibrinogen, B beta polypeptideSource|GeneCards
NRP1Neuropilin 1Source|GeneCards
CSF3colony stimulating factor 3 (granulocyte)Source|GeneCards
CHRM1cholinergic receptor, muscarinic 1Source|GeneCards
FLT3LGfms-related tyrosine kinase 3 ligandSource|GeneCards
CTF1cardiotrophin 1Source|GeneCards
EGFepidermal growth factor (beta-urogastrone)Source|GeneCards
CDK2cyclin-dependent kinase 2Source|GeneCards
BTCbetacellulinSource|GeneCards
TBC1D8TBC1 domain family, member 8 (with GRAM domain)Source|GeneCards
VIPvasoactive intestinal peptideSource|GeneCards
TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)Source|GeneCards
TNFSF11tumor necrosis factor (ligand) superfamily, member 11Source|GeneCards
EGR4early growth response 4Source|GeneCards
CAPNS1calpain, small subunit 1Source|GeneCards
IL10interleukin 10Source|GeneCards
NAP1L1nucleosome assembly protein 1-like 1Source|GeneCards
TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, activator of NFKBSource|GeneCards
BCL6B-cell CLL/lymphoma 6 (zinc finger protein 51)Source|GeneCards
VIPR1vasoactive intestinal peptide receptor 1Source|GeneCards
LRP5low density lipoprotein receptor-related protein 5Source|GeneCards
CXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)Source|GeneCards
PBEFpre-B-cell colony-enhancing factorSource|GeneCards
CLCCharcot-Leyden crystal proteinSource|GeneCards
EDG5endothelial differentiation, sphingolipid G-protein-coupled receptor, 5Source|GeneCards
NOL1nucleolar protein 1, 120kDaSource|GeneCards
IL12RB1interleukin 12 receptor, beta 1Source|GeneCards
IL5interleukin 5 (colony-stimulating factor, eosinophil)Source|GeneCards
DIPAhepatitis delta antigen-interacting protein ASource|GeneCards
IL12RB2interleukin 12 receptor, beta 2Source|GeneCards
GLP2Rglucagon-like peptide 2 receptorSource|GeneCards
MCTS1malignant T cell amplified sequence 1Source|GeneCards
STIM1stromal interaction molecule 1Source|GeneCards
PTNpleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)Source|GeneCards
IL7interleukin 7Source|GeneCards
PTK2BPTK2B protein tyrosine kinase 2 betaSource|GeneCards
DHPSdeoxyhypusine synthaseSource|GeneCards
IL11interleukin 11Source|GeneCards
ADRA2Aadrenergic, alpha-2A-, receptorSource|GeneCards
MATKmegakaryocyte-associated tyrosine kinaseSource|GeneCards
PTHLHparathyroid hormone-like hormoneSource|GeneCards
IL6interleukin 6 (interferon, beta 2)Source|GeneCards
CD28CD28 antigen (Tp44)Source|GeneCards
CD3ECD3E antigen, epsilon polypeptide (TiT3 complex)Source|GeneCards
VEGFBvascular endothelial growth factor BSource|GeneCards
FGF18fibroblast growth factor 18Source|GeneCards
ICOSinducible T-cell co-stimulatorSource|GeneCards
FIGFc-fos induced growth factor (vascular endothelial growth factor D)Source|GeneCards
EDN1endothelin 1Source|GeneCards
C10ORF7chromosome 10 open reading frame 7Source|GeneCards
GRNgranulinSource|GeneCards
CDC25Bcell division cycle 25BSource|GeneCards
HOXC10homeo box C10Source|GeneCards
TGFBR2transforming growth factor, beta receptor II (70/80kDa)Source|GeneCards
TNFSF13Btumor necrosis factor (ligand) superfamily, member 13bSource|GeneCards
VEGFvascular endothelial growth factorSource|GeneCards
DNAJA2DnaJ (Hsp40) homolog, subfamily A, member 2Source|GeneCards
PRTN3proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)Source|GeneCards
IGF1insulin-like growth factor 1 (somatomedin C)Source|GeneCards
TCIRG1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3Source|GeneCards
REG1Aregenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)Source|GeneCards
DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)Source|GeneCards
SLAMF1signaling lymphocytic activation molecule family member 1Source|GeneCards
FGFR1OPFGFR1 oncogene partnerSource|GeneCards
LIFleukemia inhibitory factor (cholinergic differentiation factor)Source|GeneCards
HTR1A5-hydroxytryptamine (serotonin) receptor 1ASource|GeneCards
IL15interleukin 15Source|GeneCards
FGF2fibroblast growth factor 2 (basic)Source|GeneCards
CD86CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)Source|GeneCards
CSF1colony stimulating factor 1 (macrophage)Source|GeneCards
SCGFstem cell growth factor; lymphocyte secreted C-type lectinSource|GeneCards
CUL3cullin 3Source|GeneCards
SHC1SHC (Src homology 2 domain containing) transforming protein 1Source|GeneCards
TTKTTK protein kinaseSource|GeneCards
PYGO2pygopus 2Source|GeneCards
TNFSF13tumor necrosis factor (ligand) superfamily, member 13Source|GeneCards
FGGfibrinogen, gamma polypeptideSource|GeneCards
CCKBRcholecystokinin B receptorSource|GeneCards
EDG3endothelial differentiation, sphingolipid G-protein-coupled receptor, 3Source|GeneCards
IL3interleukin 3 (colony-stimulating factor, multiple)Source|GeneCards
VEGFCvascular endothelial growth factor CSource|GeneCards
UBE2Cubiquitin-conjugating enzyme E2CSource|GeneCards
RPL31ribosomal protein L31Source|GeneCards
PGFplacental growth factor, vascular endothelial growth factor-related proteinSource|GeneCards
IRS2insulin receptor substrate 2Source|GeneCards
FLT3fms-related tyrosine kinase 3Source|GeneCards


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