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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: ST_T_CELL_SIGNAL_TRANSDUCTION (C2:PATH:0280)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>ST_T_CELL_SIGNAL_TRANSDUCTION</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PATH:0280</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PATH: Pathway database</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>na</pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'>More details for this gene set:<br><a href='http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7019' target='EXTERNAL'>http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7019</a><br></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Generic</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'><a href='http://stke.sciencemag.org/' target='EXTERNAL'>Signalling Transduction KE</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='ST_T_CELL_SIGNAL_TRANSDUCTION.grp'>grp</a>|<a href='ST_T_CELL_SIGNAL_TRANSDUCTION.xml'>xml</a>|<a href='ST_T_CELL_SIGNAL_TRANSDUCTION.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>45 genes, 45 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>PAK4</td><td>p21(CDKN1A)-activated kinase 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PAK4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PAK4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LAT</td><td>linker for activation of T cells</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LAT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LAT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ZAP70</td><td>zeta-chain (TCR) associated protein kinase 70kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ZAP70' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ZAP70' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>VAV1</td><td>vav 1 oncogene</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=VAV1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?VAV1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKBIA</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SOS1</td><td>son of sevenless homolog 1 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SOS1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SOS1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CTLA4</td><td>cytotoxic T-lymphocyte-associated protein 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CTLA4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CTLA4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GRAP2</td><td>GRB2-related adaptor protein 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GRAP2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GRAP2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LCK</td><td>lymphocyte-specific protein tyrosine kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LCK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LCK' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LCP2</td><td>lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LCP2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LCP2' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>PAK3</td><td>p21 (CDKN1A)-activated kinase 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PAK3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PAK3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PTPRC</td><td>protein tyrosine phosphatase, receptor type, C</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PTPRC' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PTPRC' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CSK</td><td>c-src tyrosine kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CSK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CSK' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SOS2</td><td>son of sevenless homolog 2 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SOS2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SOS2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFAT5</td><td>nuclear factor of activated T-cells 5, tonicity-responsive</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFAT5' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFAT5' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKBIB</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PAK6</td><td>p21(CDKN1A)-activated kinase 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PAK6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PAK6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NCK1</td><td>NCK adaptor protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NCK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NCK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PLCG1</td><td>phospholipase C, gamma 1 (formerly subtype 148)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PLCG1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PLCG1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PAK1</td><td>p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PAK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PAK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ITK</td><td>IL2-inducible T-cell kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITK' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CD3D</td><td>CD3D antigen, delta polypeptide (TiT3 complex)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CD3D' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CD3D' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKB2</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKB2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKB2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ITPKB</td><td>inositol 1,4,5-trisphosphate 3-kinase B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITPKB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITPKB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RAF1</td><td>v-raf-1 murine leukemia viral oncogene homolog 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RAF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RAF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>EPHB2</td><td>EphB2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EPHB2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EPHB2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RASGRP3</td><td>RAS guanyl releasing protein 3 (calcium and DAG-regulated)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RASGRP3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RASGRP3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CBL</td><td>Cas-Br-M (murine) ecotropic retroviral transforming sequence</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CBL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CBL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKBIL2</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIL2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIL2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKBIE</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIE' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIE' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GRB2</td><td>growth factor receptor-bound protein 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GRB2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GRB2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RASGRP2</td><td>RAS guanyl releasing protein 2 (calcium and DAG-regulated)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RASGRP2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RASGRP2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PAK7</td><td>p21(CDKN1A)-activated kinase 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PAK7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PAK7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RASGRP1</td><td>RAS guanyl releasing protein 1 (calcium and DAG-regulated)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RASGRP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RASGRP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKB1</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ITPKA</td><td>inositol 1,4,5-trisphosphate 3-kinase A</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITPKA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITPKA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PAK2</td><td>p21 (CDKN1A)-activated kinase 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PAK2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PAK2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RASGRP4</td><td>RAS guanyl releasing protein 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RASGRP4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RASGRP4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MAPK1</td><td>mitogen-activated protein kinase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAPK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAPK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DTYMK</td><td>deoxythymidylate kinase (thymidylate kinase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DTYMK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DTYMK' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FBXW7</td><td>F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FBXW7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FBXW7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NFKBIL1</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIL1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIL1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DAG1</td><td>dystroglycan 1 (dystrophin-associated glycoprotein 1)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DAG1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DAG1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CD28</td><td>CD28 antigen (Tp44)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CD28' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CD28' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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