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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: il2rbPathway (C2:PATH:0132)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>il2rbPathway</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PATH:0132</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PATH: Pathway database</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>na</pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'>More details for this gene set:<br><a href='http://www.biocarta.com/pathfiles/h_il2rbPathway.asp' target='EXTERNAL'>http://www.biocarta.com/pathfiles/h_il2rbPathway.asp</a><br></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Generic</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'><a href='http://www.biocarta.com' target='EXTERNAL'>BioCarta</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='il2rbPathway.grp'>grp</a>|<a href='il2rbPathway.xml'>xml</a>|<a href='il2rbPathway.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>37 genes, 37 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>STAT5A</td><td>signal transducer and activator of transcription 5A</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=STAT5A' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?STAT5A' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SOS1</td><td>son of sevenless homolog 1 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SOS1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SOS1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MAPK3</td><td>mitogen-activated protein kinase 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAPK3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAPK3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SOCS3</td><td>suppressor of cytokine signaling 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SOCS3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SOCS3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ZNFN1A3</td><td>zinc finger protein, subfamily 1A, 3 (Aiolos)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ZNFN1A3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ZNFN1A3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>AKT1</td><td>v-akt murine thymoma viral oncogene homolog 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AKT1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AKT1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IL2RG</td><td>interleukin 2 receptor, gamma (severe combined immunodeficiency)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL2RG' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL2RG' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PIK3R1</td><td>phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PIK3R1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PIK3R1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NMI</td><td>N-myc (and STAT) interactor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NMI' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NMI' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CFLAR</td><td>CASP8 and FADD-like apoptosis regulator</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CFLAR' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CFLAR' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PPIA</td><td>peptidylprolyl isomerase A (cyclophilin A)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PPIA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PPIA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SHC1</td><td>SHC (Src homology 2 domain containing) transforming protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SHC1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SHC1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IRS1</td><td>insulin receptor substrate 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IRS1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IRS1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SOCS1</td><td>suppressor of cytokine signaling 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SOCS1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SOCS1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IL2RA</td><td>interleukin 2 receptor, alpha</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL2RA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL2RA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RPS6KB1</td><td>ribosomal protein S6 kinase, 70kDa, polypeptide 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RPS6KB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RPS6KB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MYC</td><td>V-myc myelocytomatosis viral oncogene homolog (avian)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MYC' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MYC' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RAF1</td><td>v-raf-1 murine leukemia viral oncogene homolog 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RAF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RAF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IL2RB</td><td>interleukin 2 receptor, beta</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL2RB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL2RB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>E2F1</td><td>E2F transcription factor 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=E2F1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?E2F1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BCL2</td><td>B-cell CLL/lymphoma 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BCL2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BCL2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CBL</td><td>Cas-Br-M (murine) ecotropic retroviral transforming sequence</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CBL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CBL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>STAT5B</td><td>signal transducer and activator of transcription 5B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=STAT5B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?STAT5B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HRAS</td><td>v-Ha-ras Harvey rat sarcoma viral oncogene homolog</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HRAS' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HRAS' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GRB2</td><td>growth factor receptor-bound protein 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GRB2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GRB2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CRKL</td><td>v-crk sarcoma virus CT10 oncogene homolog (avian)-like</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CRKL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CRKL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>JAK1</td><td>Janus kinase 1 (a protein tyrosine kinase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JAK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JAK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>JAK3</td><td>Janus kinase 3 (a protein tyrosine kinase, leukocyte)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JAK3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JAK3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PIK3CA</td><td>phosphoinositide-3-kinase, catalytic, alpha polypeptide</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PIK3CA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PIK3CA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PTPN6</td><td>protein tyrosine phosphatase, non-receptor type 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PTPN6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PTPN6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BAD</td><td>BCL2-antagonist of cell death</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BAD' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BAD' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>MAPK1</td><td>mitogen-activated protein kinase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAPK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAPK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FOS</td><td>v-fos FBJ murine osteosarcoma viral oncogene homolog</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FOS' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FOS' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BCL2L1</td><td>BCL2-like 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BCL2L1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BCL2L1' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>SYK</td><td>spleen tyrosine kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SYK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SYK' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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