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Gene set: CBF_MYH_ROSS (C2:PERT:0049)
Standard nameCBF_MYH_ROSS
Systematic nameC2:PERT:0049
Brief descriptionGenes that distinguish pediatric acute myeloid leukemia (AML) subtype inv(16)[CBF-beta-MYH11].
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Contemporary treatment of pediatric acute myeloid leukemia (AML)
requires the assignment of patients to specific risk groups. To
explore whether expression profiling of leukemic blasts could
accurately distinguish between the known risk groups of AML, we
analyzed 130 pediatric and 20 adult AML diagnostic bone marrow
or peripheral blood samples using the Affymetrix U133A microarray.
Class discriminating genes were identified for each of the major
prognostic subtypes of pediatric AML, including t(15;17)[PML-RARalpha],
t(8;21)[AML1-ETO], inv(16) [CBFbeta-MYH11], MLL chimeric fusion
genes, and cases classified as FAB-M7. When subsets of these genes
were used in supervised learning algorithms, an overall classification
accuracy of more than 93% was achieved. Moreover, we were able
to use the expression signatures generated from the pediatric
samples to accurately classify adult de novo AMLs with the same
genetic lesions. The class discriminating genes also provided
novel insights into the molecular pathobiology of these leukemias.
Finally, using a combined pediatric data set of 130 AMLs and 137
acute lymphoblastic leukemias, we identified an expression signature
for cases with MLL chimeric fusion genes irrespective of lineage.
Surprisingly, AMLs containing partial tandem duplications of MLL
failed to cluster with MLL chimeric fusion gene cases, suggesting
a significant difference in their underlying mechanism of transformation.
Publication URL15226186
External linksna
Keywords & MeSH headingsTranscription Factors/genetics,Prognosis,Acute,Gene Expression Profiling,P.H.S.,classification,Oncogene Proteins,Proto-Oncogenes/genetics,Risk Factors,Blood,Fusion/genetics,Humans,Leukemia,genetics,Myelocytic,Child,DNA-Binding Proteins/genetics,Cluster Analysis,Algorithms,Tandem Repeat Sequences,Bone Marrow
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

52 genes, 63 accessions (Toggle view)

AccessionGeneTitleLinks
205330_atMN1meningioma (disrupted in balanced translocation) 1Source|GeneCards
222144_atKIF17kinesin family member 17Source|GeneCards
204588_s_atSLC7A7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7Source|GeneCards
203329_atPTPRMprotein tyrosine phosphatase, receptor type, MSource|GeneCards
203923_s_atCYBBcytochrome b-245, beta polypeptide (chronic granulomatous disease)Source|GeneCards
218454_atFLJ22662hypothetical protein FLJ22662Source|GeneCards
206682_atCLEC10AC-type lectin domain family 10, member ASource|GeneCards
210314_x_atTNFSF13 /// TNFSF12-tumor necrosis factor (ligand) superfamily, member 13 /// tumor necrosis factor (ligand) superfamily, member 12-member 13Source|GeneCards
208891_atDUSP6dual specificity phosphatase 6Source|GeneCards
212830_atEGFL5EGF-like-domain, multiple 5Source|GeneCards
201968_s_atPGM1phosphoglucomutase 1Source|GeneCards
206135_atST18suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)Source|GeneCards
206200_s_atANXA11annexin A11Source|GeneCards
209396_s_atCHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Source|GeneCards
202902_s_atCTSScathepsin SSource|GeneCards
201887_atIL13RA1interleukin 13 receptor, alpha 1Source|GeneCards
206978_atCCR2chemokine (C-C motif) receptor 2 /// chemokine (C-C motif) receptor 2Source|GeneCards
211798_x_atIGLJ3immunoglobulin lambda joining 3Source|GeneCards
203535_atS100A9S100 calcium binding protein A9 (calgranulin B)Source|GeneCards
214684_atMEF2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)Source|GeneCards
34210_atCD52CD52 antigen (CAMPATH-1 antigen)Source|GeneCards
218237_s_atSLC38A1solute carrier family 38, member 1Source|GeneCards
202944_atNAGAN-acetylgalactosaminidase, alpha-Source|GeneCards
212188_atKCTD12potassium channel tetramerisation domain containing 12 /// potassium channel tetramerisation domain containing 12Source|GeneCards
214864_s_atGRHPRglyoxylate reductase/hydroxypyruvate reductaseSource|GeneCards
219243_atGIMAP4GTPase, IMAP family member 4Source|GeneCards
204037_atEDG2endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2Source|GeneCards
211794_atFYBFYN binding protein (FYB-120/130)Source|GeneCards
212552_atHPCAL1hippocalcin-like 1Source|GeneCards
212298_atNRP1neuropilin 1Source|GeneCards
201506_atTGFBItransforming growth factor, beta-induced, 68kDaSource|GeneCards
221724_s_atCLEC4AC-type lectin domain family 4, member ASource|GeneCards
206380_s_atPFCproperdin P factor, complementSource|GeneCards
202510_s_atTNFAIP2tumor necrosis factor, alpha-induced protein 2Source|GeneCards
206788_s_atCBFBcore-binding factor, beta subunitSource|GeneCards
202917_s_atS100A8S100 calcium binding protein A8 (calgranulin A)Source|GeneCards
221698_s_atCLEC7AC-type lectin domain family 7, member A /// C-type lectin domain family 7, member ASource|GeneCards
202720_atTEStestis derived transcript (3 LIM domains)Source|GeneCards
212535_atMEF2AMADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)Source|GeneCards
212192_atKCTD12potassium channel tetramerisation domain containing 12Source|GeneCards
207794_atCCR2chemokine (C-C motif) receptor 2 /// chemokine (C-C motif) receptor 2Source|GeneCards
204661_atCD52CD52 antigen (CAMPATH-1 antigen) /// CD52 antigen (CAMPATH-1 antigen)Source|GeneCards
205076_s_atMTMR11myotubularin related protein 11Source|GeneCards
204912_atIL10RAinterleukin 10 receptor, alphaSource|GeneCards
201496_x_atMYH11myosin, heavy polypeptide 11, smooth muscleSource|GeneCards
208450_atLGALS2lectin, galactoside-binding, soluble, 2 (galectin 2) /// lectin, galactoside-binding, soluble, 2 (galectin 2)Source|GeneCards
200665_s_atSPARCsecreted protein, acidic, cysteine-rich (osteonectin) /// secreted protein, acidic, cysteine-rich (osteonectin)Source|GeneCards
203973_s_atCEBPDCCAAT/enhancer binding protein (C/EBP), deltaSource|GeneCards
202370_s_atCBFBcore-binding factor, beta subunitSource|GeneCards
204036_atEDG2endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2Source|GeneCards
219308_s_atAK5adenylate kinase 5Source|GeneCards
216984_x_atIGLC2Immunoglobulin lambda variable 3-21Source|GeneCards
201497_x_atMYH11myosin, heavy polypeptide 11, smooth muscleSource|GeneCards
211645_x_atNA
201999_s_atTCTEL1t-complex-associated-testis-expressed 1-like 1Source|GeneCards
202901_x_atCTSScathepsin SSource|GeneCards
205174_s_atQPCTglutaminyl-peptide cyclotransferase (glutaminyl cyclase)Source|GeneCards
212993_atNA
209395_atCHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Source|GeneCards
208890_s_atPLXNB2plexin B2Source|GeneCards
211675_s_atMDFICMyoD family inhibitor domain containing /// MyoD family inhibitor domain containingSource|GeneCards
205987_atCD1CCD1C antigen, c polypeptideSource|GeneCards
215784_atCD1ECD1E antigen, e polypeptideSource|GeneCards


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