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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: EPITHELIAL_DOWN_ZUCCHI (C2:PERT:0113)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>EPITHELIAL_DOWN_ZUCCHI</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0113</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>The 50 most downregulated genes in primary invasive breast dutcal carcinoma or metastatic breast carcinoma isolated from lymph nodes, as compared to normal mammary epithelium.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Expression profiles of breast carcinomas are difficult to interpret
when they are obtained from tissue in toto, which may contain
a large proportion of non-cancer cells. To avoid this problem,
we microscopically isolated cells from a primary invasive ductal
carcinoma of the breast and from an axillary node harboring a
metastatic breast carcinoma, to obtain pure populations of carcinoma
cells (approximately 500) and used them for serial analysis of
gene expression. The expression profiles generated from both populations
of cells were compared with the profile of a disease-free mammary
epithelium. We showed that the expression profiles obtained are
exclusive of carcinoma cells with no contribution of non-epithelial
cells. From a total of 16,939 unique tags analyzed, we detected
559 statistically significant changes in gene expression; some
of these genes have not been previously associated with breast
cancer. We observed that many of the down-regulated genes are
the same in both cancers, whereas the up-regulated genes are completely
different, suggesting that the down-regulation of a set of genes
may be the basic mechanism of cancer formation, while the up-regulation
may characterize and possibly control the state of evolution of
individual cancers. The results obtained may help in characterizing
the neoplastic process of breast cancer. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15608061' target='EXTERNAL'>15608061</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Neoplastic,In Situ Hybridization,Epithelial Cells,Breast Neoplasms,Complementary/metabolism,DNA,Lymphatic Metastasis,Down-Regulation,Humans,Carcinoma,Epithelium/metabolism,pathology,genetics,Up-Regulation,Gene Expression Regulation,Gene Library,metabolism</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='EPITHELIAL_DOWN_ZUCCHI.grp'>grp</a>|<a href='EPITHELIAL_DOWN_ZUCCHI.xml'>xml</a>|<a href='EPITHELIAL_DOWN_ZUCCHI.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>50 genes, 50 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>RASD1</td><td>RAS, dexamethasone-induced 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RASD1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RASD1' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>BAP1</td><td>BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BAP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BAP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>EIF3S4</td><td>eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EIF3S4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EIF3S4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PFN1</td><td>profilin 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PFN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PFN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PDLIM1</td><td>PDZ and LIM domain 1 (elfin)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PDLIM1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PDLIM1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SAT</td><td>spermidine/spermine N1-acetyltransferase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SAT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SAT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TM4SF1</td><td>transmembrane 4 superfamily member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TM4SF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TM4SF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>JUND</td><td>jun D proto-oncogene</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JUND' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JUND' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SOD2</td><td>superoxide dismutase 2, mitochondrial</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SOD2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SOD2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PPM1G</td><td>protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PPM1G' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PPM1G' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DDX5</td><td>DEAD (Asp-Glu-Ala-Asp) box polypeptide 5</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DDX5' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DDX5' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TACSTD2</td><td>tumor-associated calcium signal transducer 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TACSTD2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TACSTD2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PNRC1</td><td>proline-rich nuclear receptor coactivator 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PNRC1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PNRC1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LGALS3</td><td>lectin, galactoside-binding, soluble, 3 (galectin 3)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LGALS3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LGALS3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ANXA1</td><td>annexin A1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ANXA1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ANXA1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CST3</td><td>cystatin C (amyloid angiopathy and cerebral hemorrhage)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CST3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CST3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PDCD5</td><td>programmed cell death 5</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PDCD5' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PDCD5' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CLDN4</td><td>claudin 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CLDN4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CLDN4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LIF</td><td>leukemia inhibitory factor (cholinergic differentiation factor)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LIF' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LIF' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>JUNB</td><td>jun B proto-oncogene</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JUNB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JUNB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DDB1</td><td>damage-specific DNA binding protein 1, 127kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DDB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DDB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>KRT6B</td><td>keratin 6B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KRT6B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KRT6B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CXCL3</td><td>chemokine (C-X-C motif) ligand 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CXCL3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CXCL3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>YWHAE</td><td>tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=YWHAE' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?YWHAE' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SUI1</td><td>putative translation initiation factor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SUI1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SUI1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>STRN4</td><td>striatin, calmodulin binding protein 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=STRN4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?STRN4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>AREG</td><td>amphiregulin (schwannoma-derived growth factor)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AREG' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AREG' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>SCGB1D2</td><td>secretoglobin, family 1D, member 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SCGB1D2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SCGB1D2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PICALM</td><td>phosphatidylinositol binding clathrin assembly protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PICALM' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PICALM' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CXCL1</td><td>chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CXCL1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CXCL1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LMNA</td><td>lamin A/C</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LMNA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LMNA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>KRT7</td><td>keratin 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KRT7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KRT7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LOC118430</td><td>small breast epithelial mucin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LOC118430' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LOC118430' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HMGN1</td><td>high-mobility group nucleosome binding domain 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HMGN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HMGN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ACTG1</td><td>actin, gamma 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ACTG1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ACTG1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CXCL2</td><td>chemokine (C-X-C motif) ligand 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CXCL2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CXCL2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IL8</td><td>interleukin 8</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL8' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ZYX</td><td>zyxin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ZYX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ZYX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>EIF4A1</td><td>eukaryotic translation initiation factor 4A, isoform 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EIF4A1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EIF4A1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SEC61B</td><td>Sec61 beta subunit</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SEC61B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SEC61B' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>GADD45B</td><td>growth arrest and DNA-damage-inducible, beta</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GADD45B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GADD45B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CCL20</td><td>chemokine (C-C motif) ligand 20</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCL20' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCL20' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IL6</td><td>interleukin 6 (interferon, beta 2)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL6' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>CXCL6</td><td>chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CXCL6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CXCL6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SEMA3B</td><td>sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SEMA3B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SEMA3B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ST13</td><td>suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ST13' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ST13' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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