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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: GOLDRATH_CELLCYCLE (C2:PERT:0033)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>GOLDRATH_CELLCYCLE</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0033</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Cell cycle genes induced during antigen activation of CD8+ T cells.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Naive T cells proliferate independently of cognate antigen when
introduced into lymphopenic hosts. Lymphopenia-induced proliferation
depends on low-affinity MHC/self-peptide complexes and on IL-7.
To elucidate the intracellular signals mediating this proliferation,
we analyzed changes in gene expression in naive CD8+ T cells at
different times after their transfer into a lymphopenic environment.
The genes induced in response to lymphopenia were largely an attenuated
subset of those turned up by full antigenic stimulation, including
genes related to cell cycling, whereas excluding genes specifically
associated with effector activity. After the initial phase of
proliferation in an empty compartment, the naive T cells adopted
a stable pattern of gene expression similar to that of antigen-experienced
memory cells. Thus, T cells proliferating in lymphopenic hosts
do not exhibit a unique gene-expression profile, instead relying
on "traditional" signals for this antigen-independent proliferation;
this process ultimately results in differentiation to "authentic"
memory cells. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15548615' target='EXTERNAL'>15548615</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>DNA Probes,Homeostasis,Gene Expression Profiling,P.H.S.,Female,Mice,Base Sequence,cytology,Cell Division,T-Lymphocytes,Inbred C57BL,immunology</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>MG_U74Av2</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='GOLDRATH_CELLCYCLE.grp'>grp</a>|<a href='GOLDRATH_CELLCYCLE.xml'>xml</a>|<a href='GOLDRATH_CELLCYCLE.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>34 genes, 36 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='4' class='fancy' border='0'><tr><th align='center'>Accession</th><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td width='75%'>160496_s_at</td><td>MCM3</td><td>minichromosome maintenance deficient 3 (S. cerevisiae)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MCM3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MCM3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>101973_at</td><td>CITED2</td><td>Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CITED2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CITED2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>160638_at</td><td>CDKN2C</td><td>cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDKN2C' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDKN2C' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>92639_at</td><td>AURKA</td><td>aurora kinase A</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AURKA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AURKA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>161172_f_at</td><td>BRRN1</td><td>barren homolog (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BRRN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BRRN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>104598_at</td><td>DUSP1</td><td>dual specificity phosphatase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DUSP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DUSP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>99522_at</td><td>GSG2</td><td>germ cell-specific gene 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GSG2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GSG2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>98469_at</td><td>AURKB</td><td>aurora kinase B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AURKB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AURKB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>100062_at</td><td>MCM3</td><td>minichromosome maintenance deficient 3 (S. cerevisiae)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MCM3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MCM3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>103416_at</td><td>MAPK6</td><td>mitogen-activated protein kinase 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAPK6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAPK6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>95527_at</td><td>CHAF1A</td><td>chromatin assembly factor 1, subunit A (p150)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CHAF1A' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CHAF1A' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>99186_at</td><td>CCNA2</td><td>cyclin A2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCNA2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCNA2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>104097_at</td><td>BUB1</td><td>budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BUB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BUB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>103064_at</td><td>CHEK1</td><td>checkpoint kinase 1 homolog (S. pombe)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CHEK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CHEK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>160069_at</td><td>GMNN</td><td>geminin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GMNN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GMNN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>100133_at</td><td>FYN</td><td>Fyn proto-oncogene</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FYN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FYN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>100885_at</td><td>NEK2</td><td>NIMA (never in mitosis gene a)-related expressed kinase 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NEK2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NEK2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>103349_at</td><td>LYN</td><td>Yamaguchi sarcoma viral (v-yes-1) oncogene homolog</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LYN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LYN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>103821_at</td><td>CDC6</td><td>cell division cycle 6 homolog (S. cerevisiae)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDC6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDC6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>97411_at</td><td>ECT2</td><td>ect2 oncogene</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ECT2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ECT2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>100128_at</td><td>CDC2A</td><td>cell division cycle 2 homolog A (S. pombe)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDC2A' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDC2A' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>97527_at</td><td>CKS2</td><td>CDC28 protein kinase regulatory subunit 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CKS2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CKS2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>99632_at</td><td>MAD2L1</td><td>MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAD2L1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAD2L1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>94768_at</td><td>RAD21</td><td>RAD21 homolog (S. pombe)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RAD21' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RAD21' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>98996_at</td><td>PLK4</td><td>polo-like kinase 4 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PLK4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PLK4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>94294_at</td><td>CCNB2</td><td>cyclin B2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCNB2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCNB2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>101254_at</td><td>RAN</td><td>RAN, member RAS oncogene family</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RAN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RAN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>97238_at</td><td>TACC3</td><td>transforming, acidic coiled-coil containing protein 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TACC3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TACC3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>102403_at</td><td>CDC45L</td><td>cell division cycle 45 homolog (S. cerevisiae)-like</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDC45L' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDC45L' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>92770_at</td><td>S100A6</td><td>S100 calcium binding protein A6 (calcyclin)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=S100A6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?S100A6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>95753_at</td><td>BRRN1</td><td>barren homolog (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BRRN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BRRN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>160159_at</td><td>CCNB1-RS1 /// CCNB1</td><td>cyclin B1, related sequence 1 /// cyclin B1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCNB1-RS1 /// CCNB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCNB1-RS1 /// CCNB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>97468_at</td><td>CKS1B</td><td>CDC28 protein kinase 1b</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CKS1B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CKS1B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>93758_at</td><td>INCENP</td><td>inner centromere protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=INCENP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?INCENP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>99073_at</td><td>CCNF</td><td>cyclin F</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCNF' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCNF' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>93099_f_at</td><td>PLK1</td><td>polo-like kinase 1 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PLK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PLK1' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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