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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: HOXA9_DOWN_DORSAM (C2:PERT:0028)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>HOXA9_DOWN_DORSAM</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0028</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes downregulated by HOXA9</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Hematopoietic defects in HOXA9(-/-) mice demonstrate a key role
for this homeoprotein in blood cell development. Conversely, enforced
HOXA9 expression is leukemogenic in mice, and HOXA9 is frequently
activated in human acute myeloid leukemia (AML). Although HOXA9
is thought to function as a transcription factor, few downstream
targets have been identified. We searched for early HOXA9 target
genes by using a transient overexpression strategy in 3 hematopoietic
cell lines (2 myeloid, 1 lymphoid). cDNA microarray analyses identified
220 genes whose expression was modulated at least 2-fold. Expression
signatures in myeloid and lymphoid cells demonstrated that HOXA9
functions as both an activator and repressor of a variety of genes
in cell-specific patterns suggesting that the transcriptional
effects of HOXA9 are largely dependent on the cell context. Transient
transcription assays and target gene expression patterns in HOXA9(-/-)
marrow cells imply that we have identified direct physiologic
targets. Many target genes are expressed in CD34+ stem cells or
are members of gene families involved in proliferation or myeloid
differentiation. Expression of 14 HOXA9 target genes correlated
with high-level HOXA9 expression in primary AML. These data suggest
that many genes identified in this survey may mediate the biologic
effects of HOXA9 in normal and leukemic hematopoiesis. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14604967' target='EXTERNAL'>14604967</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Oligonucleotide Array Sequence Analysis,P.H.S.,Transfection,Human,Support,Hematopoietic Stem Cells,genetics,Up-Regulation,Genetic,Homeodomain Proteins,U937 Cells,Jurkat Cells,metabolism,RNA,DNA,Complementary/metabolism,Non-P.H.S.,DNA/chemistry,Transcription,Messenger,Down-Regulation,Leukemia,K562 Cells,Reverse Transcriptase Polymerase Chain Reaction,Gene Expression Regulation,Luciferase/metabolism,Cell Division,biosynthesis,Bone Marrow Cells/cytology</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'><a href='http://www.broad.mit.edu' target='EXTERNAL'>Broad Institute</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='HOXA9_DOWN_DORSAM.grp'>grp</a>|<a href='HOXA9_DOWN_DORSAM.xml'>xml</a>|<a href='HOXA9_DOWN_DORSAM.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>32 genes, 32 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>IGF2</td><td>insulin-like growth factor 2 (somatomedin A)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IGF2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IGF2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>WSB1</td><td>SOCS box-containing WD protein SWiP-1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=WSB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?WSB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CD36</td><td>CD36 antigen (collagen type I receptor, thrombospondin receptor)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CD36' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CD36' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>JUNB</td><td>jun B proto-oncogene</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JUNB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JUNB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>KRT18</td><td>keratin 18</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KRT18' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KRT18' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SFRS11</td><td>splicing factor, arginine/serine-rich 11</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SFRS11' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SFRS11' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GATA2</td><td>GATA binding protein 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GATA2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GATA2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MAN2A2</td><td>mannosidase, alpha, class 2A, member 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAN2A2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAN2A2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CDC37</td><td>CDC37 cell division cycle 37 homolog (S. cerevisiae)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDC37' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDC37' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SBNO1</td><td>sno, strawberry notch homolog 1 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SBNO1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SBNO1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SERPINB9</td><td>serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SERPINB9' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SERPINB9' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>JUN</td><td>v-jun sarcoma virus 17 oncogene homolog (avian)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JUN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JUN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TPR</td><td>translocated promoter region (to activated MET oncogene)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TPR' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TPR' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SDCBP</td><td>syndecan binding protein (syntenin)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SDCBP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SDCBP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RBBP6</td><td>retinoblastoma binding protein 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RBBP6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RBBP6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SDC4</td><td>syndecan 4 (amphiglycan, ryudocan)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SDC4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SDC4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ARNTL</td><td>aryl hydrocarbon receptor nuclear translocator-like</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ARNTL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ARNTL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DSIPI</td><td>delta sleep inducing peptide, immunoreactor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DSIPI' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DSIPI' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MYC</td><td>V-myc myelocytomatosis viral oncogene homolog (avian)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MYC' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MYC' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FCGRT</td><td>Fc fragment of IgG, receptor, transporter, alpha</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FCGRT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FCGRT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GLRX</td><td>glutaredoxin (thioltransferase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GLRX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GLRX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SRP72</td><td>signal recognition particle 72kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SRP72' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SRP72' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LYN</td><td>v-yes-1 Yamaguchi sarcoma viral related oncogene homolog</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LYN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LYN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DCT</td><td>dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DCT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DCT' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>HBE1</td><td>hemoglobin, epsilon 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HBE1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HBE1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CLCN7</td><td>chloride channel 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CLCN7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CLCN7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>VHL</td><td>von Hippel-Lindau syndrome</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=VHL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?VHL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>OSBPL8</td><td>oxysterol binding protein-like 8</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=OSBPL8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?OSBPL8' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FXR1</td><td>fragile X mental retardation, autosomal homolog 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FXR1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FXR1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CISH</td><td>cytokine inducible SH2-containing protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CISH' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CISH' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DNCLI2</td><td>dynein, cytoplasmic, light intermediate polypeptide 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DNCLI2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DNCLI2' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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