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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: INSULIN_2F_DOWN_ROME (C2:PERT:0003)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>INSULIN_2F_DOWN_ROME</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0003</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes 2fold dowregulated by insulin</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Insulin action in target tissues involved precise regulation of
gene expression. To define the set of insulin-regulated genes
in human skeletal muscle, we analyzed the global changes in mRNA
levels during a 3-h hyperinsulinemic euglycemic clamp in vastus
lateralis muscle of six healthy subjects. Using 29,308 cDNA element
microarrays, we found that the mRNA expression of 762 genes, including
353 expressed sequence tags, was significantly modified during
insulin infusion. 478 were up-regulated and 284 down-regulated.
Most of the genes with known function are novel targets of insulin.
They are involved in the transcriptional and translational regulation
(29%), intermediary and energy metabolisms (14%), intracellular
signaling (12%), and cytoskeleton and vesicle traffic (9%). Other
categories consisted of genes coding for receptors, carriers,
and transporters (8%), components of the ubiquitin/proteasome
pathways (7%) and elements of the immune response (5.5%). These
results thus define a transcriptional signature of insulin action
in human skeletal muscle. They will help to better define the
mechanisms involved in the reduction of insulin effectiveness
in pathologies such as type 2 diabetes mellitus, a disease characterized
by defective regulation of gene expression in response to insulin.
</pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12621037' target='EXTERNAL'>12621037</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Oligonucleotide Array Sequence Analysis,Hyperinsulinism,Messenger/metabolism,Cysteine Endopeptidases/metabolism,Multienzyme Complexes/metabolism,Insulin,Up-Regulation,Muscle,Biological,Genetic,Ubiquitin/metabolism,Nucleic Acid Hybridization,metabolism,Protein Biosynthesis,Male,Proteasome Endopeptidase Complex,RNA,DNA,Complementary/metabolism,Skeletal,Female,Models,Transcription,Down-Regulation,RNA/metabolism,Humans,Biological Transport,Signal Transduction,Reverse Transcriptase Polymerase Chain Reaction,Gene Expression Regulation</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'><a href='http://www.broad.mit.edu' target='EXTERNAL'>Broad Institute</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='INSULIN_2F_DOWN_ROME.grp'>grp</a>|<a href='INSULIN_2F_DOWN_ROME.xml'>xml</a>|<a href='INSULIN_2F_DOWN_ROME.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>36 genes, 36 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>CYP4A11</td><td>cytochrome P450, family 4, subfamily A, polypeptide 11</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CYP4A11' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CYP4A11' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MSH5</td><td>mutS homolog 5 (E. coli)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MSH5' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MSH5' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>B1</td><td>Parathyroid hormone-responsive B1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=B1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?B1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TGFB2</td><td>transforming growth factor, beta 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TGFB2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TGFB2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>KIAA1117</td><td>KIAA1117</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KIAA1117' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KIAA1117' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>C10ORF10</td><td>chromosome 10 open reading frame 10</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=C10ORF10' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?C10ORF10' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CNTN2</td><td>contactin 2 (axonal)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CNTN2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CNTN2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CPA1</td><td>carboxypeptidase A1 (pancreatic)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CPA1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CPA1' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>ELA3A</td><td>elastase 3A, pancreatic (protease E)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ELA3A' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ELA3A' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CLTB</td><td>clathrin, light polypeptide (Lcb)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CLTB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CLTB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BRD4</td><td>bromodomain containing 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BRD4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BRD4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MLL</td><td>myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MLL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MLL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CRYBA4</td><td>crystallin, beta A4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CRYBA4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CRYBA4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FLJ10815</td><td>hypothetical protein FLJ10815</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FLJ10815' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FLJ10815' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NIN</td><td>ninein (GSK3B interacting protein)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NIN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NIN' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>CDC16</td><td>CDC16 cell division cycle 16 homolog (S. cerevisiae)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDC16' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDC16' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TCL6</td><td>T-cell leukemia/lymphoma 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TCL6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TCL6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PCDH17</td><td>protocadherin 17</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PCDH17' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PCDH17' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BCL10</td><td>B-cell CLL/lymphoma 10</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BCL10' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BCL10' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>KIAA0746</td><td>KIAA0746 protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KIAA0746' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KIAA0746' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TOX</td><td>thymus high mobility group box protein TOX</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TOX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TOX' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>ALMS1</td><td>Alstrom syndrome 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ALMS1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ALMS1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>C6ORF4</td><td>chromosome 6 open reading frame 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=C6ORF4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?C6ORF4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FNBP3</td><td>formin binding protein 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FNBP3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FNBP3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TGM3</td><td>transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TGM3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TGM3' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>SH2D3C</td><td>SH2 domain containing 3C</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SH2D3C' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SH2D3C' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SERPINA1</td><td>serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SERPINA1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SERPINA1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PRKX</td><td>protein kinase, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PRKX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PRKX' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>KIAA1430</td><td>KIAA1430 protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KIAA1430' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KIAA1430' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FBXL6</td><td>F-box and leucine-rich repeat protein 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FBXL6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FBXL6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MMP23B</td><td>matrix metalloproteinase 23B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MMP23B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MMP23B' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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