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Gene set: INSULIN_2F_UP_ROME (C2:PERT:0004)
Standard nameINSULIN_2F_UP_ROME
Systematic nameC2:PERT:0004
Brief descriptionGenes 2fold upregulated by insulin
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Insulin action in target tissues involved precise regulation of
gene expression. To define the set of insulin-regulated genes
in human skeletal muscle, we analyzed the global changes in mRNA
levels during a 3-h hyperinsulinemic euglycemic clamp in vastus
lateralis muscle of six healthy subjects. Using 29,308 cDNA element
microarrays, we found that the mRNA expression of 762 genes, including
353 expressed sequence tags, was significantly modified during
insulin infusion. 478 were up-regulated and 284 down-regulated.
Most of the genes with known function are novel targets of insulin.
They are involved in the transcriptional and translational regulation
(29%), intermediary and energy metabolisms (14%), intracellular
signaling (12%), and cytoskeleton and vesicle traffic (9%). Other
categories consisted of genes coding for receptors, carriers,
and transporters (8%), components of the ubiquitin/proteasome
pathways (7%) and elements of the immune response (5.5%). These
results thus define a transcriptional signature of insulin action
in human skeletal muscle. They will help to better define the
mechanisms involved in the reduction of insulin effectiveness
in pathologies such as type 2 diabetes mellitus, a disease characterized
by defective regulation of gene expression in response to insulin.
Publication URL12621037
External linksna
Keywords & MeSH headingsOligonucleotide Array Sequence Analysis,Hyperinsulinism,Messenger/metabolism,Cysteine Endopeptidases/metabolism,Multienzyme Complexes/metabolism,Insulin,Up-Regulation,Muscle,Biological,Genetic,Ubiquitin/metabolism,Nucleic Acid Hybridization,metabolism,Protein Biosynthesis,Male,Proteasome Endopeptidase Complex,RNA,DNA,Complementary/metabolism,Skeletal,Female,Models,Transcription,Down-Regulation,RNA/metabolism,Humans,Biological Transport,Signal Transduction,Reverse Transcriptase Polymerase Chain Reaction,Gene Expression Regulation
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
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Genes

235 genes, 235 accessions (Toggle view)

GeneTitleLinks
MSI2musashi homolog 2 (Drosophila)Source|GeneCards
FHL3four and a half LIM domains 3Source|GeneCards
HK2hexokinase 2Source|GeneCards
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideSource|GeneCards
ASH1Lash1 (absent, small, or homeotic)-like (Drosophila)Source|GeneCards
KARSlysyl-tRNA synthetaseSource|GeneCards
CANXcalnexinSource|GeneCards
PPP2R3Aprotein phosphatase 2 (formerly 2A), regulatory subunit B'', alphaSource|GeneCards
GLRXglutaredoxin (thioltransferase)Source|GeneCards
PXMP3peroxisomal membrane protein 3, 35kDa (Zellweger syndrome)Source|GeneCards
PAMpeptidylglycine alpha-amidating monooxygenaseSource|GeneCards
LSM3LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)Source|GeneCards
ZNF9zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)Source|GeneCards
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideSource|GeneCards
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 2Source|GeneCards
IFIT1interferon-induced protein with tetratricopeptide repeats 1Source|GeneCards
GNPDA1glucosamine-6-phosphate deaminase 1Source|GeneCards
ARCN1archain 1Source|GeneCards
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1Source|GeneCards
HNRPDLheterogeneous nuclear ribonucleoprotein D-likeSource|GeneCards
VDAC1voltage-dependent anion channel 1Source|GeneCards
ASCL1achaete-scute complex-like 1 (Drosophila)Source|GeneCards
NRD1nardilysin (N-arginine dibasic convertase)Source|GeneCards
SNAPAPSNARE associated protein snapinSource|GeneCards
TSG101tumor susceptibility gene 101Source|GeneCards
ADSLadenylosuccinate lyaseSource|GeneCards
LAPTM4Alysosomal-associated protein transmembrane 4 alphaSource|GeneCards
SUI1putative translation initiation factorSource|GeneCards
PSARLpresenilin associated, rhomboid-likeSource|GeneCards
SCOCshort coiled-coil proteinSource|GeneCards
DNCL1dynein, cytoplasmic, light polypeptide 1Source|GeneCards
NFE2L1nuclear factor (erythroid-derived 2)-like 1Source|GeneCards
PTP4A1protein tyrosine phosphatase type IVA, member 1Source|GeneCards
WBSCR1Williams-Beuren syndrome chromosome region 1Source|GeneCards
UBE2E3ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)Source|GeneCards
FLJ11506hypothetical protein FLJ11506Source|GeneCards
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)Source|GeneCards
UBA2SUMO-1 activating enzyme subunit 2Source|GeneCards
CDK2AP1CDK2-associated protein 1Source|GeneCards
H2AFZH2A histone family, member ZSource|GeneCards
SLC25A12solute carrier family 25 (mitochondrial carrier, Aralar), member 12Source|GeneCards
BUB1BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)Source|GeneCards
TRIM32tripartite motif-containing 32Source|GeneCards
SDBCAG84serologically defined breast cancer antigen 84Source|GeneCards
SH3GLB1SH3-domain GRB2-like endophilin B1Source|GeneCards
SETSET translocation (myeloid leukemia-associated)Source|GeneCards
CLNS1Achloride channel, nucleotide-sensitive, 1ASource|GeneCards
CCL16chemokine (C-C motif) ligand 16Source|GeneCards
UBBubiquitin BSource|GeneCards
GNPATglyceronephosphate O-acyltransferaseSource|GeneCards
FLJ11021similar to splicing factor, arginine/serine-rich 4Source|GeneCards
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)Source|GeneCards
USP9Xubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)Source|GeneCards
RBX1ring-box 1Source|GeneCards
PRO2730hypothetical protein PRO2730Source|GeneCards
QARSGlutaminyl-tRNA synthetaseSource|GeneCards
MRPS16mitochondrial ribosomal protein S16Source|GeneCards
VPS29vacuolar protein sorting 29 (yeast)Source|GeneCards
ZNF44zinc finger protein 44 (KOX 7)Source|GeneCards
AKAP6A kinase (PRKA) anchor protein 6Source|GeneCards
SPARCL1SPARC-like 1 (mast9, hevin)Source|GeneCards
PAIP2poly(A) binding protein interacting protein 2Source|GeneCards
MGC5508hypothetical protein MGC5508Source|GeneCards
CRI1CREBBP/EP300 inhibitory protein 1Source|GeneCards
ORF1-FL49putative nuclear protein ORF1-FL49Source|GeneCards
CAMLGcalcium modulating ligandSource|GeneCards
HADHSCL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainSource|GeneCards
STSsteroid sulfatase (microsomal), arylsulfatase C, isozyme SSource|GeneCards
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)Source|GeneCards
NT5C35'-nucleotidase, cytosolic IIISource|GeneCards
OSR1odd-skipped related 1 (Drosophila)Source|GeneCards
PTMAprothymosin, alpha (gene sequence 28)Source|GeneCards
CMAScytidine monophosphate N-acetylneuraminic acid synthetaseSource|GeneCards
HECTD1HECT domain containing 1Source|GeneCards
IL13RA1interleukin 13 receptor, alpha 1Source|GeneCards
SORBS1sorbin and SH3 domain containing 1Source|GeneCards
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDaSource|GeneCards
ARPP-19cyclic AMP phosphoprotein, 19 kDSource|GeneCards
FEM1Bfem-1 homolog b (C. elegans)Source|GeneCards
PURBpurine-rich element binding protein BSource|GeneCards
IPO7importin 7Source|GeneCards
AHCYL1S-adenosylhomocysteine hydrolase-like 1Source|GeneCards
PGAM1phosphoglycerate mutase 1 (brain)Source|GeneCards
PSMD13proteasome (prosome, macropain) 26S subunit, non-ATPase, 13Source|GeneCards
SDCBPsyndecan binding protein (syntenin)Source|GeneCards
UBQLN1ubiquilin 1Source|GeneCards
ALDOAaldolase A, fructose-bisphosphateSource|GeneCards
VIMvimentinSource|GeneCards
EEF1Geukaryotic translation elongation factor 1 gammaSource|GeneCards
SNRPB2small nuclear ribonucleoprotein polypeptide B''Source|GeneCards
OXA1Loxidase (cytochrome c) assembly 1-likeSource|GeneCards
SERPINF1serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1Source|GeneCards
ADFPadipose differentiation-related proteinSource|GeneCards
COX7A2cytochrome c oxidase subunit VIIa polypeptide 2 (liver)Source|GeneCards
PDE4Dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)Source|GeneCards
HSF2heat shock transcription factor 2Source|GeneCards
GYGglycogeninSource|GeneCards
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast)Source|GeneCards
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Source|GeneCards
GMPRguanosine monophosphate reductaseSource|GeneCards
RPLP1ribosomal protein, large, P1Source|GeneCards
GBASglioblastoma amplified sequenceSource|GeneCards
NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)Source|GeneCards
ITGAEintegrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)Source|GeneCards
CSDAcold shock domain protein ASource|GeneCards
CD36CD36 antigen (collagen type I receptor, thrombospondin receptor)Source|GeneCards
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14Source|GeneCards
FNTAfarnesyltransferase, CAAX box, alphaSource|GeneCards
TIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
TALDO1transaldolase 1Source|GeneCards
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1Source|GeneCards
JTV1JTV1 geneSource|GeneCards
HDGFhepatoma-derived growth factor (high-mobility group protein 1-like)Source|GeneCards
C21ORF7chromosome 21 open reading frame 7Source|GeneCards
TAF7TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDaSource|GeneCards
PRDX1peroxiredoxin 1Source|GeneCards
S100A7S100 calcium binding protein A7 (psoriasin 1)Source|GeneCards
PSMA6proteasome (prosome, macropain) subunit, alpha type, 6Source|GeneCards
CAPN2calpain 2, (m/II) large subunitSource|GeneCards
TERF2IPtelomeric repeat binding factor 2, interacting proteinSource|GeneCards
C1Scomplement component 1, s subcomponentSource|GeneCards
PPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12ASource|GeneCards
ALS2CR2amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2Source|GeneCards
VCLvinculinSource|GeneCards
TCTEL1t-complex-associated-testis-expressed 1-like 1Source|GeneCards
ZAKsterile alpha motif and leucine zipper containing kinase AZKSource|GeneCards
NACAnascent-polypeptide-associated complex alpha polypeptideSource|GeneCards
CLECSF2C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced)Source|GeneCards
BTF3basic transcription factor 3Source|GeneCards
PSMB4proteasome (prosome, macropain) subunit, beta type, 4Source|GeneCards
ADHFE1alcohol dehydrogenase, iron containing, 1Source|GeneCards
TM4SF2transmembrane 4 superfamily member 2Source|GeneCards
PLNphospholambanSource|GeneCards
FBP2fructose-1,6-bisphosphatase 2Source|GeneCards
IHPK3inositol hexaphosphate kinase 3Source|GeneCards
ANXA7annexin A7Source|GeneCards
TM4SF3transmembrane 4 superfamily member 3Source|GeneCards
MTCH2mitochondrial carrier homolog 2 (C. elegans)Source|GeneCards
G3BPRas-GTPase-activating protein SH3-domain-binding proteinSource|GeneCards
DC13DC13 proteinSource|GeneCards
UACAuveal autoantigen with coiled-coil domains and ankyrin repeatsSource|GeneCards
LAMR1laminin receptor 1 (ribosomal protein SA, 67kDa)Source|GeneCards
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)Source|GeneCards
GPSN2glycoprotein, synaptic 2Source|GeneCards
NDUFS4NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)Source|GeneCards
MAP4microtubule-associated protein 4Source|GeneCards
MORF4L2mortality factor 4 like 2Source|GeneCards
UGP2UDP-glucose pyrophosphorylase 2Source|GeneCards
STARD7START domain containing 7Source|GeneCards
ACYP2acylphosphatase 2, muscle typeSource|GeneCards
C17ORF35chromosome 17 open reading frame 35Source|GeneCards
ARF4ADP-ribosylation factor 4Source|GeneCards
GTF2A2general transcription factor IIA, 2, 12kDaSource|GeneCards
HBBhemoglobin, betaSource|GeneCards
SYNPO2Lsynaptopodin 2-likeSource|GeneCards
ODC1ornithine decarboxylase 1Source|GeneCards
MAT2Amethionine adenosyltransferase II, alphaSource|GeneCards
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)Source|GeneCards
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideSource|GeneCards
USP22ubiquitin specific protease 22Source|GeneCards
C20ORF108chromosome 20 open reading frame 108Source|GeneCards
PABPC4poly(A) binding protein, cytoplasmic 4 (inducible form)Source|GeneCards
VCPvalosin-containing proteinSource|GeneCards
GSTA4glutathione S-transferase A4Source|GeneCards
PRDX6peroxiredoxin 6Source|GeneCards
CLCN3chloride channel 3Source|GeneCards
NCKAP1NCK-associated protein 1Source|GeneCards
UBE3Aubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)Source|GeneCards
KIAA0830KIAA0830 proteinSource|GeneCards
RPL7Aribosomal protein L7aSource|GeneCards
DREV1DORA reverse strand protein 1Source|GeneCards
MGC2963hypothetical protein MGC2963Source|GeneCards
RPL41ribosomal protein L41Source|GeneCards
CFL2cofilin 2 (muscle)Source|GeneCards
USP16ubiquitin specific peptidase 16Source|GeneCards
SLC39A14solute carrier family 39 (zinc transporter), member 14Source|GeneCards
DPYSL3dihydropyrimidinase-like 3Source|GeneCards
SPOPspeckle-type POZ proteinSource|GeneCards
TPM1tropomyosin 1 (alpha)Source|GeneCards
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)Source|GeneCards
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4Source|GeneCards
ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)Source|GeneCards
CCT8chaperonin containing TCP1, subunit 8 (theta)Source|GeneCards
RNF10ring finger protein 10Source|GeneCards
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit c''Source|GeneCards
EPM2Aepilepsy, progressive myoclonus type 2A, Lafora disease (laforin)Source|GeneCards
LDHBlactate dehydrogenase BSource|GeneCards
LAPTM4Blysosomal associated protein transmembrane 4 betaSource|GeneCards
LMCD1LIM and cysteine-rich domains 1Source|GeneCards
UBE2V2ubiquitin-conjugating enzyme E2 variant 2Source|GeneCards
SLC35B1solute carrier family 35, member B1Source|GeneCards
MAOBmonoamine oxidase BSource|GeneCards
HSPC016hypothetical protein HSPC016Source|GeneCards
CD59CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)Source|GeneCards
DDX1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1Source|GeneCards
MGC2452hypothetical protein MGC2452Source|GeneCards
NFIAnuclear factor I/ASource|GeneCards
SRP14signal recognition particle 14kDa (homologous Alu RNA binding protein)Source|GeneCards
RPS20ribosomal protein S20Source|GeneCards
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)Source|GeneCards
PGRMC2progesterone receptor membrane component 2Source|GeneCards
RAB5ARAB5A, member RAS oncogene familySource|GeneCards
HLA-Cmajor histocompatibility complex, class I, CSource|GeneCards
DDX48DEAD (Asp-Glu-Ala-Asp) box polypeptide 48Source|GeneCards
PUM2pumilio homolog 2 (Drosophila)Source|GeneCards
BCL2L2BCL2-like 2Source|GeneCards
LARGElike-glycosyltransferaseSource|GeneCards
PSMA3proteasome (prosome, macropain) subunit, alpha type, 3Source|GeneCards
C3ORF1chromosome 3 open reading frame 1Source|GeneCards
FLJ10081hypothetical protein FLJ10081Source|GeneCards
ACTBactin, betaSource|GeneCards


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