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Gene set: LU_IL4BCELL (C2:PERT:0095)
Standard nameLU_IL4BCELL
Systematic nameC2:PERT:0095
Brief descriptionGenes induced in peripheral B cells by 4 hours of incubation with the cytokine IL-4.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract

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Diffuse large B-cell lymphomas (DLBCLs) can be subclassified into
germinal center B-cell (GCB)-like and activated B-cell (ABC)-like
tumors characterized by long and short survival, respectively.
In contrast to ABC-like DLBCL, GCB-like tumors exhibit high expression
of components of the interleukin 4 (IL-4) signaling pathway and
of IL-4 target genes such as BCL6 and HGAL, whose high expression
independently predicts better survival. These observations suggest
distinct activity of the IL-4 signaling pathway in DLBCL subtypes.
Herein, we demonstrate similar IL-4 expression but qualitatively
different IL-4 effects on GCB-like and ABC-like DLBCL. In GCB-like
DLBCL, IL-4 induces expression of its target genes, activates
signal transducers and activators of transcription 6 (STAT6) signaling,
and increases cell proliferation. In contrast, in the ABC-like
DLBCL, IL-4 activates AKT, decreases cell proliferation by cell
cycle arrest, and does not induce gene expression due to aberrant
Janus kinase (JAK)-STAT6 signaling attributed to STAT6 dephosphorylation.
We found distinct expression profiles of tyrosine phosphatases
in DLBCL subtypes and identified putative STAT6 tyrosine phosphatases-protein
tyrosine phosphatase nonreceptor type 1 (PTPN1) and PTPN2, whose
expression is significantly higher in ABC-like DLBCL. These differences
in tyrosine phosphatase expression might underlie distinct expression
profiles of some of the IL-4 target genes and could contribute
to a different clinical outcome of patients with GCB-like and
ABC-like DLBCLs. 
Publication URL15591113
External linksna
Keywords & MeSH headingsna
OrganismHuman
Contributed byKate Stafford
Source platformGene_Symbol
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Genes

97 genes, 97 accessions (Toggle view)

GeneTitleLinks
MRPS15mitochondrial ribosomal protein S15Source|GeneCards
CLTCclathrin, heavy polypeptide (Hc)Source|GeneCards
WT1Wilms tumor 1Source|GeneCards
SLASrc-like-adaptorSource|GeneCards
SAMSN1SAM domain, SH3 domain and nuclear localisation signals, 1Source|GeneCards
RGS6regulator of G-protein signalling 6Source|GeneCards
EGR1early growth response 1Source|GeneCards
KIAA0802KIAA0802 proteinSource|GeneCards
LY75lymphocyte antigen 75Source|GeneCards
CFLARCASP8 and FADD-like apoptosis regulatorSource|GeneCards
CTSDcathepsin D (lysosomal aspartyl protease)Source|GeneCards
RPS2ribosomal protein S2Source|GeneCards
KIAA1627KIAA1627 proteinSource|GeneCards
BCKDKbranched chain alpha-ketoacid dehydrogenase kinaseSource|GeneCards
ARPC5actin related protein 2/3 complex, subunit 5, 16kDaSource|GeneCards
VCLvinculinSource|GeneCards
MALmal, T-cell differentiation proteinSource|GeneCards
TLR3toll-like receptor 3Source|GeneCards
NFIL3nuclear factor, interleukin 3 regulatedSource|GeneCards
SLC15A2solute carrier family 15 (H+/peptide transporter), member 2Source|GeneCards
TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, activator of NFKBSource|GeneCards
RPL5ribosomal protein L5Source|GeneCards
BCL6B-cell CLL/lymphoma 6 (zinc finger protein 51)Source|GeneCards
RAGErenal tumor antigenSource|GeneCards
IL4Rinterleukin 4 receptorSource|GeneCards
PMAIP1phorbol-12-myristate-13-acetate-induced protein 1Source|GeneCards
EIF4G1eukaryotic translation initiation factor 4 gamma, 1Source|GeneCards
FCER2Fc fragment of IgE, low affinity II, receptor for (CD23A)Source|GeneCards
SPAG1sperm associated antigen 1Source|GeneCards
PPP2CAprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformSource|GeneCards
IL6interleukin 6 (interferon, beta 2)Source|GeneCards
XBP1X-box binding protein 1Source|GeneCards
NCF2neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)Source|GeneCards
PDE7Aphosphodiesterase 7ASource|GeneCards
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
QSCN6quiescin Q6Source|GeneCards
KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase)Source|GeneCards
NCOA3nuclear receptor coactivator 3Source|GeneCards
HLX1H2.0-like homeo box 1 (Drosophila)Source|GeneCards
EBFearly B-cell factorSource|GeneCards
NEK6NIMA (never in mitosis gene a)-related kinase 6Source|GeneCards
FGL2fibrinogen-like 2Source|GeneCards
BATFbasic leucine zipper transcription factor, ATF-likeSource|GeneCards
IL2RAinterleukin 2 receptor, alphaSource|GeneCards
CD79BCD79B antigen (immunoglobulin-associated beta)Source|GeneCards
CTGFconnective tissue growth factorSource|GeneCards
STAT4signal transducer and activator of transcription 4Source|GeneCards
SPINT2serine protease inhibitor, Kunitz type, 2Source|GeneCards
AKAP2A kinase (PRKA) anchor protein 2Source|GeneCards
MAP3K5mitogen-activated protein kinase kinase kinase 5Source|GeneCards
GNG2guanine nucleotide binding protein (G protein), gamma 2Source|GeneCards
ALOX5arachidonate 5-lipoxygenaseSource|GeneCards
KLF13Kruppel-like factor 13Source|GeneCards
CISHcytokine inducible SH2-containing proteinSource|GeneCards
EVI2Aecotropic viral integration site 2ASource|GeneCards
BHLHB2basic helix-loop-helix domain containing, class B, 2Source|GeneCards
CD86CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)Source|GeneCards
CNTN6contactin 6Source|GeneCards
HLA-DRB5major histocompatibility complex, class II, DR beta 5Source|GeneCards
TLR7toll-like receptor 7Source|GeneCards
KIAA0746KIAA0746 proteinSource|GeneCards
SELLselectin L (lymphocyte adhesion molecule 1)Source|GeneCards
HOXC4homeo box C4Source|GeneCards
GSRglutathione reductaseSource|GeneCards
CD69CD69 antigen (p60, early T-cell activation antigen)Source|GeneCards
STK4serine/threonine kinase 4Source|GeneCards
PPP6Cprotein phosphatase 6, catalytic subunitSource|GeneCards
SIAH2seven in absentia homolog 2 (Drosophila)Source|GeneCards
TNFAIP3tumor necrosis factor, alpha-induced protein 3Source|GeneCards


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