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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: MGUS_MM_DAVIES (C2:PERT:0093)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>MGUS_MM_DAVIES</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0093</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes differentially expressed in monoclonal gammopathy of uncertain significance (MGUS, a precursor state for multiple myeloma) versus multiple myeloma (MM) plasma cells. Fold Change uses MGUS as the baseline.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>To define specific pathways important in the multistep transformation
process of normal plasma cells (PCs) to monoclonal gammopathy
of uncertain significance (MGUS) and multiple myeloma (MM), we
have applied microarray analysis to PCs from 5 healthy donors
(N), 7 patients with MGUS, and 24 patients with newly diagnosed
MM. Unsupervised hierarchical clustering using 125 genes with
a large variation across all samples defined 2 groups: N and MGUS/MM.
Supervised analysis identified 263 genes differentially expressed
between N and MGUS and 380 genes differentially expressed between
N and MM, 197 of which were also differentially regulated between
N and MGUS. Only 74 genes were differentially expressed between
MGUS and MM samples, indicating that the differences between MGUS
and MM are smaller than those between N and MM or N and MGUS.
Differentially expressed genes included oncogenes/tumor-suppressor
genes (LAF4, RB1, and disabled homolog 2), cell-signaling genes
(RAS family members, B-cell signaling and NF-kappaB genes), DNA-binding
and transcription-factor genes (XBP1, zinc finger proteins, forkhead
box, and ring finger proteins), and developmental genes (WNT and
SHH pathways). Understanding the molecular pathogenesis of MM
by gene expression profiling has demonstrated sequential genetic
changes from N to malignant PCs and highlighted important pathways
involved in the transformation of MGUS to MM. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12947006' target='EXTERNAL'>12947006</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Neoplastic,Non-P.H.S.,Gene Expression Profiling,Oligonucleotide Array Sequence Analysis,P.H.S.,Comparative Study,Oncogene Proteins/biosynthesis/genetics,Multiple Myeloma,Neoplasm Proteins/biosynthesis/genetics,Humans,Disease Progression,pathology,Paraproteinemias,Transcription Factors/biosynthesis/genetics,genetics,Gene Expression Regulation,Precancerous Conditions,Subtraction Technique,DNA-Binding Proteins/biosynthesis/genetics</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='MGUS_MM_DAVIES.grp'>grp</a>|<a href='MGUS_MM_DAVIES.xml'>xml</a>|<a href='MGUS_MM_DAVIES.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>41 genes, 41 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>PPBP</td><td>pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PPBP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PPBP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TNFRSF7</td><td>tumor necrosis factor receptor superfamily, member 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TNFRSF7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TNFRSF7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PITX3</td><td>paired-like homeodomain transcription factor 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PITX3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PITX3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RNASE6</td><td>ribonuclease, RNase A family, k6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RNASE6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RNASE6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NPC2</td><td>Niemann-Pick disease, type C2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NPC2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NPC2' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr></tr><tr><td>CTSG</td><td>cathepsin G</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CTSG' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CTSG' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DOK1</td><td>docking protein 1, 62kDa (downstream of tyrosine kinase 1)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DOK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DOK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MYH9</td><td>myosin, heavy polypeptide 9, non-muscle</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MYH9' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MYH9' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ITGA8</td><td>integrin, alpha 8</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITGA8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITGA8' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SLC7A7</td><td>solute carrier family 7 (cationic amino acid transporter, y+ system), member 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SLC7A7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SLC7A7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>UBE2G2</td><td>ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=UBE2G2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?UBE2G2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RPS6KA4</td><td>ribosomal protein S6 kinase, 90kDa, polypeptide 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RPS6KA4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RPS6KA4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ACTN1</td><td>actinin, alpha 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ACTN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ACTN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TLR1</td><td>toll-like receptor 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TLR1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TLR1' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>S100A8</td><td>S100 calcium binding protein A8 (calgranulin A)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=S100A8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?S100A8' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GLUL</td><td>glutamate-ammonia ligase (glutamine synthase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GLUL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GLUL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PFTK1</td><td>PFTAIRE protein kinase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PFTK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PFTK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RING1</td><td>ring finger protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RING1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RING1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LILRB1</td><td>leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LILRB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LILRB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FAT</td><td>FAT tumor suppressor homolog 1 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FAT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FAT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SAT</td><td>spermidine/spermine N1-acetyltransferase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SAT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SAT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MARCKS</td><td>myristoylated alanine-rich protein kinase C substrate</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MARCKS' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MARCKS' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TMSB4X</td><td>thymosin, beta 4, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TMSB4X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TMSB4X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>VCL</td><td>vinculin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=VCL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?VCL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HIST1H2BG</td><td>histone 1, H2bg</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HIST1H2BG' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HIST1H2BG' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MERTK</td><td>c-mer proto-oncogene tyrosine kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MERTK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MERTK' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LY96</td><td>lymphocyte antigen 96</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LY96' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LY96' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DEFA3</td><td>defensin, alpha 3, neutrophil-specific</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DEFA3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DEFA3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LASP1</td><td>LIM and SH3 protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LASP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LASP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FRZB</td><td>frizzled-related protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FRZB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FRZB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ADD1</td><td>adducin 1 (alpha)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ADD1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ADD1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>VNN2</td><td>vanin 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=VNN2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?VNN2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ARHGAP1</td><td>Rho GTPase activating protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ARHGAP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ARHGAP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PDE6G</td><td>phosphodiesterase 6G, cGMP-specific, rod, gamma</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PDE6G' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PDE6G' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LITAF</td><td>lipopolysaccharide-induced TNF factor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LITAF' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LITAF' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>MFNG</td><td>manic fringe homolog (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MFNG' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MFNG' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SGCE</td><td>sarcoglycan, epsilon</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SGCE' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SGCE' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FCER1G</td><td>Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FCER1G' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FCER1G' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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