[an error occurred while processing this directive]
Gene set: OKUMURA_MC_LPS (C2:PERT:0046)
Standard nameOKUMURA_MC_LPS
Systematic nameC2:PERT:0046
Brief descriptionGenes whose expression is induced in human mast cells (MCs) by lipopolysaccharide treatment.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Rodent mast cells (MCs) are reported to play a pivotal role in
both innate and adaptive immunity. However, there is so far no
evidence that human MCs are involved in innate immunity. We found
that a functional Toll-like receptor 4 (TLR4) was expressed on
human MCs when it was up-regulated by interferon gamma (IFN-gamma).
To systematically explore how human MCs modulate the immune system
following TLR4-mediated activation and FcepsilonRI aggregation,
we used high-density oligonucleotide probe arrays (GeneChip) to
compare the lipopolysaccharide (LPS)-induced gene expression profile
with the IgE/anti-IgE-mediated profile in MCs. Both a shared core
response, and LPS- or anti-IgE-specific programs of gene expression
were observed in MCs. Furthermore, MCs exhibited an antiviral
response gene program in response to IFN-gamma, and LPS sustained
that expression. Compared with the LPS-stimulated gene expression
profile of human peripheral blood mononuclear cells, LPS-stimulated
MCs specifically induced a subset of genes that included a Th2
cytokine and chemokines that recruit Th2 cells and eosinophils.
These results reveal that human MCs express tailored pathogen-
and antigen-specific immune responses and that human MCs may play
important roles in innate and adaptive immunity. 
Publication URL12855579
External linksna
Keywords & MeSH headingsMembrane Glycoproteins,Gene Expression Profiling,Interleukin-5/metabolism,Lipopolysaccharides/pharmacology,Tumor Necrosis Factor-alpha/biosynthesis,IgE,Humans,Monocytes/cytology/physiology,Mast Cells,Receptors,genetics,Lung/cytology,physiology,Enzyme-Linked Immunosorbent Assay,Gene Expression Regulation/drug effects/immunology,metabolism,Cell Surface
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

183 genes, 218 accessions (Toggle view)

AccessionGeneTitleLinks
210117_atSPAG1sperm associated antigen 1Source|GeneCards
218854_atSART2squamous cell carcinoma antigen recognized by T cells 2Source|GeneCards
218335_x_atTNIP2TNFAIP3 interacting protein 2Source|GeneCards
216860_s_atGDF11growth differentiation factor 11Source|GeneCards
207526_s_atIL1RL1interleukin 1 receptor-like 1Source|GeneCards
209424_s_atAMACRalpha-methylacyl-CoA racemaseSource|GeneCards
205308_atCGI-62CGI-62 proteinSource|GeneCards
206067_s_atWT1Wilms tumor 1Source|GeneCards
215787_atACTA2Actin, alpha 2, smooth muscle, aortaSource|GeneCards
216609_atTXNThioredoxinSource|GeneCards
213635_s_atSAFBScaffold attachment factor BSource|GeneCards
218885_s_atGALNT12UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)Source|GeneCards
215577_atUBE2E1Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)Source|GeneCards
210187_atFKBP1AFK506 binding protein 1A, 12kDaSource|GeneCards
207196_s_atTNIP1TNFAIP3 interacting protein 1Source|GeneCards
203963_atCA12carbonic anhydrase XIISource|GeneCards
212322_atSGPL1sphingosine-1-phosphate lyase 1Source|GeneCards
218284_atSMAD3SMAD, mothers against DPP homolog 3 (Drosophila)Source|GeneCards
201915_atSEC63SEC63-like (S. cerevisiae)Source|GeneCards
206950_atSCN9Asodium channel, voltage-gated, type IX, alphaSource|GeneCards
206003_atCEP4centrosomal protein 4Source|GeneCards
204702_s_atNFE2L3nuclear factor (erythroid-derived 2)-like 3Source|GeneCards
217665_atNA
203347_s_atMTF2metal response element binding transcription factor 2Source|GeneCards
207528_s_atSLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 11Source|GeneCards
214729_atTWISTNBTWIST neighborSource|GeneCards
203561_atFCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)Source|GeneCards
215092_s_atNFAT5nuclear factor of activated T-cells 5, tonicity-responsiveSource|GeneCards
221808_atRAB9ARAB9A, member RAS oncogene familySource|GeneCards
217966_s_atC1ORF24chromosome 1 open reading frame 24Source|GeneCards
209568_s_atRGL1ral guanine nucleotide dissociation stimulator-like 1Source|GeneCards
220311_atC21ORF127chromosome 21 open reading frame 127Source|GeneCards
203348_s_atETV5ets variant gene 5 (ets-related molecule)Source|GeneCards
201670_s_atMARCKSmyristoylated alanine-rich protein kinase C substrateSource|GeneCards
202834_atAGTangiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8)Source|GeneCards
213260_atFOXC1Forkhead box C1Source|GeneCards
201951_atALCAMactivated leukocyte cell adhesion moleculeSource|GeneCards
213221_s_atSNF1LK2SNF1-like kinase 2Source|GeneCards
213972_atNA
209582_s_atCD200CD200 antigenSource|GeneCards
219279_atDOCK10dedicator of cytokinesis 10Source|GeneCards
213142_x_atLOC54103hypothetical protein LOC54103Source|GeneCards
203124_s_atSLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
218899_s_atBAALCbrain and acute leukemia, cytoplasmicSource|GeneCards
206036_s_atRELv-rel reticuloendotheliosis viral oncogene homolog (avian)Source|GeneCards
204235_s_atGULP1GULP, engulfment adaptor PTB domain containing 1Source|GeneCards
211352_s_atNCOA3nuclear receptor coactivator 3Source|GeneCards
203588_s_atTFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
218018_atPDXKpyridoxal (pyridoxine, vitamin B6) kinaseSource|GeneCards
216989_atSPAM1sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)Source|GeneCards
201810_s_atSH3BP5SH3-domain binding protein 5 (BTK-associated)Source|GeneCards
215726_s_atCYB5cytochrome b-5Source|GeneCards
209493_atPDZK3PDZ domain containing 3Source|GeneCards
217393_x_atUBE2NLubiquitin-conjugating enzyme E2N-likeSource|GeneCards
210884_s_atSPAG11sperm associated antigen 11Source|GeneCards
203221_atTLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)Source|GeneCards
201513_atTSNtranslinSource|GeneCards
220491_atHAMPhepcidin antimicrobial peptideSource|GeneCards
219105_x_atORC6Lorigin recognition complex, subunit 6 homolog-like (yeast)Source|GeneCards
212230_atPPAP2Bphosphatidic acid phosphatase type 2BSource|GeneCards
217762_s_atRAB31RAB31, member RAS oncogene familySource|GeneCards
205094_atPEX12peroxisomal biogenesis factor 12Source|GeneCards
214009_atMSL3L1male-specific lethal 3-like 1 (Drosophila)Source|GeneCards
212743_atRCHY1ring finger and CHY zinc finger domain containing 1Source|GeneCards
214620_x_atPAMpeptidylglycine alpha-amidating monooxygenaseSource|GeneCards
216994_s_atRUNX2runt-related transcription factor 2Source|GeneCards
215825_atNA
204523_atZNF140zinc finger protein 140 (clone pHZ-39)Source|GeneCards
207533_atCCL1chemokine (C-C motif) ligand 1Source|GeneCards
207072_atIL18RAPinterleukin 18 receptor accessory proteinSource|GeneCards
209921_atSLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 11Source|GeneCards
212656_atTSFMTs translation elongation factor, mitochondrialSource|GeneCards
203349_s_atETV5ets variant gene 5 (ets-related molecule)Source|GeneCards
206729_atTNFRSF8tumor necrosis factor receptor superfamily, member 8Source|GeneCards
206648_atZNF571zinc finger protein 571Source|GeneCards
214038_atCCL8chemokine (C-C motif) ligand 8Source|GeneCards
202644_s_atTNFAIP3tumor necrosis factor, alpha-induced protein 3Source|GeneCards
222006_atFGFR3Fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)Source|GeneCards
212911_atNA
219380_x_atPOLHpolymerase (DNA directed), etaSource|GeneCards
204720_s_atDNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6Source|GeneCards
205842_s_atJAK2Janus kinase 2 (a protein tyrosine kinase)Source|GeneCards
213582_atATP11AATPase, Class VI, type 11ASource|GeneCards
204999_s_atATF5activating transcription factor 5Source|GeneCards
217591_atSKILSKI-likeSource|GeneCards
217996_atPHLDA1pleckstrin homology-like domain, family A, member 1Source|GeneCards
219683_atFZD3frizzled homolog 3 (Drosophila)Source|GeneCards
205768_s_atSLC27A2solute carrier family 27 (fatty acid transporter), member 2Source|GeneCards
65630_atLOC283232hypothetical protein LOC283232Source|GeneCards
213386_atNA
205396_atSMAD3SMAD, mothers against DPP homolog 3 (Drosophila)Source|GeneCards
201416_atSOX4SRY (sex determining region Y)-box 4Source|GeneCards
201489_atPPIFpeptidylprolyl isomerase F (cyclophilin F)Source|GeneCards
210375_atPTGER3prostaglandin E receptor 3 (subtype EP3)Source|GeneCards
205830_atCLGNcalmeginSource|GeneCards
212741_atMAOAmonoamine oxidase ASource|GeneCards
215354_s_atPELP1proline-, glutamic acid-, leucine-rich protein 1Source|GeneCards
204655_atCCL5chemokine (C-C motif) ligand 5 /// chemokine (C-C motif) ligand 5Source|GeneCards
213002_atMARCKSMyristoylated alanine-rich protein kinase C substrateSource|GeneCards
201564_s_atFSCN1fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)Source|GeneCards
213454_atAPITD1apoptosis-inducing, TAF9-like domain 1Source|GeneCards
204255_s_atVDRvitamin D (1,25- dihydroxyvitamin D3) receptorSource|GeneCards
217894_atKCTD3potassium channel tetramerisation domain containing 3Source|GeneCards
201963_atACSL1acyl-CoA synthetase long-chain family member 1Source|GeneCards
217166_atNA
221987_s_atFLJ10534hypothetical protein FLJ10534Source|GeneCards
203038_atPTPRKprotein tyrosine phosphatase, receptor type, KSource|GeneCards
204388_s_atMAOAmonoamine oxidase ASource|GeneCards
204435_atNUPL1nucleoporin like 1Source|GeneCards
205847_atPRSS22protease, serine, 22Source|GeneCards
221653_x_atAPOL2apolipoprotein L, 2Source|GeneCards
203987_atFZD6frizzled homolog 6 (Drosophila)Source|GeneCards
210933_s_atFSCN1fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)Source|GeneCards
210286_s_atSLC4A7solute carrier family 4, sodium bicarbonate cotransporter, member 7Source|GeneCards
209366_x_atCYB5cytochrome b-5Source|GeneCards
203589_s_atTFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
201975_atRSNrestin (Reed-Steinberg cell-expressed intermediate filament-associated protein)Source|GeneCards
210716_s_atRSNrestin (Reed-Steinberg cell-expressed intermediate filament-associated protein)Source|GeneCards
201873_s_atABCE1ATP-binding cassette, sub-family E (OABP), member 1Source|GeneCards
221425_s_atHBLD2HESB like domain containing 2 /// HESB like domain containing 2Source|GeneCards
207426_s_atTNFSF4tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)Source|GeneCards
210319_x_atMSX2msh homeo box homolog 2 (Drosophila)Source|GeneCards
207843_x_atCYB5cytochrome b-5Source|GeneCards
212931_atTCF20transcription factor 20 (AR1)Source|GeneCards
202705_atCCNB2cyclin B2Source|GeneCards
219374_s_atALG9asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase)Source|GeneCards
218812_s_atC7ORF19chromosome 7 open reading frame 19Source|GeneCards
210004_atOLR1oxidised low density lipoprotein (lectin-like) receptor 1Source|GeneCards
217967_s_atC1ORF24chromosome 1 open reading frame 24Source|GeneCards
203125_x_atSLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
200644_atMARCKSL1MARCKS-like 1Source|GeneCards
219257_s_atSPHK1sphingosine kinase 1Source|GeneCards
216437_atEPC1Enhancer of polycomb homolog 1 (Drosophila)Source|GeneCards
206756_atCHST7carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7Source|GeneCards
219289_atFLJ20718hypothetical protein FLJ20718Source|GeneCards
218775_s_atBOMBBH3-only member B proteinSource|GeneCards
219429_atFA2Hfatty acid 2-hydroxylaseSource|GeneCards
218697_atNCKIPSDNCK interacting protein with SH3 domainSource|GeneCards
201110_s_atTHBS1thrombospondin 1Source|GeneCards
212609_s_atAKT3V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)Source|GeneCards
217678_atSLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 11Source|GeneCards
219112_atRAPGEF6Rap guanine nucleotide exchange factor (GEF) 6Source|GeneCards
204267_x_atPKMYT1protein kinase, membrane associated tyrosine/threonine 1Source|GeneCards
201669_s_atMARCKSmyristoylated alanine-rich protein kinase C substrateSource|GeneCards
205451_atMLLT7myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7Source|GeneCards
209884_s_atSLC4A7solute carrier family 4, sodium bicarbonate cotransporter, member 7Source|GeneCards
40016_g_atMAST4microtubule associated serine/threonine kinase family member 4Source|GeneCards
203010_atSTAT5Asignal transducer and activator of transcription 5ASource|GeneCards
220232_atSCD5stearoyl-CoA desaturase 5Source|GeneCards
201952_atALCAMactivated leukocyte cell adhesion moleculeSource|GeneCards
214011_s_atHSPC111hypothetical protein HSPC111Source|GeneCards
210598_atNA
212321_atNA
213922_atTTBK2tau tubulin kinase 2Source|GeneCards
206867_atGCKRglucokinase (hexokinase 4) regulatorSource|GeneCards
219412_atRAB38RAB38, member RAS oncogene familySource|GeneCards
219489_s_atNXNnucleoredoxinSource|GeneCards
206698_atXKKell blood group precursor (McLeod phenotype)Source|GeneCards
222343_atBCL2L11BCL2-like 11 (apoptosis facilitator)Source|GeneCards
201016_atEIF1AXeukaryotic translation initiation factor 1A, X-linkedSource|GeneCards
211967_atPORIMINpro-oncosis receptor inducing membrane injury geneSource|GeneCards
202334_s_atUBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)Source|GeneCards
204998_s_atATF5activating transcription factor 5Source|GeneCards
206518_s_atRGS9regulator of G-protein signalling 9Source|GeneCards
216170_atCHCHD3Coiled-coil-helix-coiled-coil-helix domain containing 3Source|GeneCards
204059_s_atME1malic enzyme 1, NADP(+)-dependent, cytosolicSource|GeneCards
220908_atFLJ32855hypothetical protein FLJ32855Source|GeneCards
218712_atC1ORF109chromosome 1 open reading frame 109Source|GeneCards
37424_atCCHCR1coiled-coil alpha-helical rod protein 1Source|GeneCards
204064_atTHOC1THO complex 1Source|GeneCards
210538_s_atBIRC3baculoviral IAP repeat-containing 3Source|GeneCards
208129_x_atRUNX1runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)Source|GeneCards
210176_atTLR1toll-like receptor 1Source|GeneCards
220954_s_atPILRBpaired immunoglobin-like type 2 receptor betaSource|GeneCards
205950_s_atCA1carbonic anhydrase ISource|GeneCards
222062_atIL27RAinterleukin 27 receptor, alphaSource|GeneCards
218940_atC14ORF138chromosome 14 open reading frame 138Source|GeneCards
217853_atTENS1Tensin-like SH2 domain containing 1Source|GeneCards
217471_atNA
218981_atACN9ACN9 homolog (S. cerevisiae)Source|GeneCards
202859_x_atIL8interleukin 8Source|GeneCards
205841_atJAK2Janus kinase 2 (a protein tyrosine kinase)Source|GeneCards
221571_atTRAF3TNF receptor-associated factor 3Source|GeneCards
220352_x_atMGC4278hypothetical protein MGC4278Source|GeneCards
202896_s_atPTPNS1protein tyrosine phosphatase, non-receptor type substrate 1Source|GeneCards
214079_atDHRS2dehydrogenase/reductase (SDR family) member 2Source|GeneCards
205567_atCHST1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1Source|GeneCards
213285_atTMEM30Btransmembrane protein 30BSource|GeneCards
222301_atCROC4Transcriptional activator of the c-fos promoterSource|GeneCards
205769_atSLC27A2solute carrier family 27 (fatty acid transporter), member 2Source|GeneCards
204389_atMAOAmonoamine oxidase ASource|GeneCards
214097_atRPS21ribosomal protein S21Source|GeneCards
206337_atCCR7chemokine (C-C motif) receptor 7 /// chemokine (C-C motif) receptor 7Source|GeneCards
203123_s_atSLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
205205_atRELBv-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)Source|GeneCards
201811_x_atSH3BP5SH3-domain binding protein 5 (BTK-associated)Source|GeneCards
219993_atSOX17SRY (sex determining region Y)-box 17Source|GeneCards
218710_atFLJ20272hypothetical protein FLJ20272Source|GeneCards
219150_s_atCENTA1centaurin, alpha 1Source|GeneCards
207980_s_atCITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Source|GeneCards
202071_atSDC4syndecan 4 (amphiglycan, ryudocan)Source|GeneCards
203973_s_atCEBPDCCAAT/enhancer binding protein (C/EBP), deltaSource|GeneCards
202073_atOPTNoptineurinSource|GeneCards
217764_s_atRAB31RAB31, member RAS oncogene familySource|GeneCards
216514_atNA
36920_atMTM1myotubularin 1Source|GeneCards
222175_s_atPCQAPPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinSource|GeneCards
217680_x_atNA
210533_atMSH4mutS homolog 4 (E. coli)Source|GeneCards
204897_atPTGER4prostaglandin E receptor 4 (subtype EP4)Source|GeneCards
209258_s_atCSPG6chondroitin sulfate proteoglycan 6 (bamacan)Source|GeneCards
219778_atZFPM2zinc finger protein, multitype 2Source|GeneCards
203946_s_atARG2arginase, type IISource|GeneCards
205590_atRASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated)Source|GeneCards
207952_atIL5interleukin 5 (colony-stimulating factor, eosinophil)Source|GeneCards
201346_atADIPOR2adiponectin receptor 2Source|GeneCards
205398_s_atSMAD3SMAD, mothers against DPP homolog 3 (Drosophila)Source|GeneCards
203426_s_atIGFBP5insulin-like growth factor binding protein 5Source|GeneCards


[an error occurred while processing this directive]