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Gene set: PEL_UP_KLEIN (C2:PERT:0043)
Standard namePEL_UP_KLEIN
Systematic nameC2:PERT:0043
Brief descriptionGenes downregulated in AIDS-related primary effusion lymphoma (PEL) cells compared to normal B cells and other tumor subtypes.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
AIDS-related primary effusion lymphoma (PEL) is an HIV-associated
malignancy characterized by the ability of the tumor cells to
specifically home in the serous body cavities. Here we used gene
expression profile analysis (about 12 000 genes) to further define
the phenotype of PEL and to investigate the lymphoma relationship
to normal B cells and to other tumor subtypes, including non-Hodgkin
lymphomas (NHLs) of immunocompetent hosts and AIDS-associated
NHL (AIDS-NHL). The results showed that PEL displayed a common
gene expression profile that is clearly distinct from all NHLs
of immunocompetent hosts and AIDS-NHL subtypes and, in contrast
to those, is not related to germinal center (GC) or memory B cells.
The gene expression profile of PEL was defined as plasmablastic
because it showed features of both immunoblasts identified by
Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines
and AIDS immunoblastic lymphoma, and plasma cells, as defined
by multiple myeloma cell lines. Finally, our results identify
a set of genes specifically expressed in PEL tumor cells. Their
expression was validated at the protein level, suggesting their
potential pathogenetic and clinical significance.
Publication URL12531789
External linksna
Keywords & MeSH headingsetiology,Gene Expression Profiling/methods,Lymphoma,Non-P.H.S.,P.H.S.,Comparative Study,classification,Transcription,Phenotype,Humans,pathology,B-Lymphocytes/immunology,Non-Hodgkin/genetics/pathology,genetics,Genetic,HIV Infections/complications/genetics
OrganismHuman
Contributed byKate Stafford
Source platformHG_U95Av2
Downloadgrp|xml|map
Genes

50 genes, 58 accessions (Toggle view)

AccessionGeneTitleLinks
1365_atIL2RBinterleukin 2 receptor, betaSource|GeneCards
36100_atVEGFvascular endothelial growth factorSource|GeneCards
38465_atPAMpeptidylglycine alpha-amidating monooxygenaseSource|GeneCards
31591_s_atCFHL4 /// CFHL3complement factor H-related 4 /// complement factor H-related 3Source|GeneCards
35928_atTPOthyroid peroxidaseSource|GeneCards
1410_atVDRvitamin D (1,25- dihydroxyvitamin D3) receptorSource|GeneCards
38783_atMUC1mucin 1, transmembraneSource|GeneCards
35671_atGTF3C1general transcription factor IIIC, polypeptide 1, alpha 220kDaSource|GeneCards
36184_atPLOD1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1Source|GeneCards
39824_atPTP4A3Protein tyrosine phosphatase type IVA, member 3Source|GeneCards
40757_atGZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)Source|GeneCards
38316_atALDH1L1aldehyde dehydrogenase 1 family, member L1Source|GeneCards
32837_atAGPAT21-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)Source|GeneCards
34720_atNFIBnuclear factor I/BSource|GeneCards
111_atRABGGTARab geranylgeranyltransferase, alpha subunitSource|GeneCards
39122_atGPIglucose phosphate isomeraseSource|GeneCards
35192_atGLDCglycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)Source|GeneCards
37276_atIQGAP2IQ motif containing GTPase activating protein 2Source|GeneCards
39358_atNCOR2nuclear receptor co-repressor 2Source|GeneCards
39021_atDPY19L1dpy-19-like 1 (C. elegans)Source|GeneCards
37037_atP4HA1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide ISource|GeneCards
32855_atLDLRlow density lipoprotein receptor (familial hypercholesterolemia)Source|GeneCards
39248_atAQP3aquaporin 3Source|GeneCards
33971_f_atDAZLdeleted in azoospermia-likeSource|GeneCards
31779_s_atPRDM1PR domain containing 1, with ZNF domainSource|GeneCards
39790_atATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2Source|GeneCards
33972_r_atDAZLdeleted in azoospermia-likeSource|GeneCards
36035_atGPAA1GPAA1P anchor attachment protein 1 homolog (yeast)Source|GeneCards
37625_atIRF4interferon regulatory factor 4Source|GeneCards
40354_atHSPA4Lheat shock 70kDa protein 4-likeSource|GeneCards
100_g_atRABGGTARab geranylgeranyltransferase, alpha subunitSource|GeneCards
38281_atCASP7caspase 7, apoptosis-related cysteine proteaseSource|GeneCards
41046_s_atZNF261zinc finger protein 261Source|GeneCards
927_s_atMUC1mucin 1, transmembraneSource|GeneCards
35698_atIFI factor (complement)Source|GeneCards
700_s_atNA
1548_s_atIL10interleukin 10Source|GeneCards
36069_atSRGAP2SLIT-ROBO Rho GTPase activating protein 2Source|GeneCards
38081_atLTA4Hleukotriene A4 hydrolaseSource|GeneCards
33862_atPPAP2Bphosphatidic acid phosphatase type 2BSource|GeneCards
34929_atTNFRSF8tumor necrosis factor receptor superfamily, member 8Source|GeneCards
37541_atSELPLGselectin P ligandSource|GeneCards
37040_atGANABglucosidase, alpha; neutral ABSource|GeneCards
32751_atILF3interleukin enhancer binding factor 3, 90kDaSource|GeneCards
36008_atPTP4A3protein tyrosine phosphatase type IVA, member 3Source|GeneCards
40414_atVARSvalyl-tRNA synthetaseSource|GeneCards
38161_atALG3asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)Source|GeneCards
32454_atNA
41724_atBCAP31B-cell receptor-associated protein 31Source|GeneCards
38282_atADAM15a disintegrin and metalloproteinase domain 15 (metargidin)Source|GeneCards
36234_atEIF4A1Eukaryotic translation initiation factor 4A, isoform 1Source|GeneCards
35355_atDHX30DEAH (Asp-Glu-Ala-His) box polypeptide 30Source|GeneCards
33308_atGUSBglucuronidase, betaSource|GeneCards
36676_atRPN2ribophorin IISource|GeneCards
39249_atAQP3aquaporin 3Source|GeneCards
1647_atIQGAP2IQ motif containing GTPase activating protein 2Source|GeneCards
31804_f_atSULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1Source|GeneCards
386_g_atCTRLchymotrypsin-likeSource|GeneCards

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