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Gene set: SASAKI_TSLC1 (C2:PERT:0086)
Standard nameSASAKI_TSLC1
Systematic nameC2:PERT:0086
Brief descriptionGenes overexpressed at least twofold in adult T-cell lymphoma (ATL) cells versus normal CD4+ and CD4+/CD45RO+ T cells.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus
type 1 (HTLV-1) infection, occurs in 2% to 4% of the HTLV-1 carriers
with a long latent period, suggesting that additional alterations
participate in the development of ATL. To characterize and identify
novel markers of ATL, we examined the expression profiles of more
than 12 000 genes in 8 cases of acute-type ATL using microarray.
One hundred ninety-two genes containing interleukin 2 (IL-2) receptor
alpha were up-regulated more than 2-fold compared with CD4(+)
and CD4(+)CD45RO(+) T cells, and tumor suppressor in lung cancer
1 (TSLC1), caveolin 1, and prostaglandin D2 synthase showed increased
expression of more than 30-fold. TSLC1 is a cell adhesion molecule
originally identified as a tumor suppressor in the lung but lacks
its expression in normal or activated T cells. We confirmed ectopic
expression of the TSLC1 in all acute-type ATL cells and in 7 of
10 ATL- or HTLV-1-infected T-cell lines. Introduction of TSLC1
into a human ATL cell line ED enhanced both self-aggregation and
adhesion ability to vascular endothelial cells. These results
suggested that the ectopic expression of TSLC1 could provide a
novel marker for acute-type ATL and may participate in tissue
invasion, a characteristic feature of the malignant ATL cells.
Publication URL15471956
External linksna
Keywords & MeSH headingsMale,T-Cell,Cell Line,Middle Aged,Acute,80 and over,Female,Membrane Proteins,Endothelium,Immunoglobulins,analysis,Tumor Markers,Humans,Leukemia,genetics,Aged,Leukocyte Count,Biological/analysis,Vascular/pathology
OrganismHuman
Contributed byKate Stafford
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

145 genes, 190 accessions (Toggle view)

AccessionGeneTitleLinks
AB014566DAAM1dishevelled associated activator of morphogenesis 1Source|GeneCards
Y00097ANXA6annexin A6Source|GeneCards
U63743KIF2Ckinesin family member 2CSource|GeneCards
M16279CD99CD99 antigenSource|GeneCards
AA203476
U65410MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)Source|GeneCards
M84443GALK2galactokinase 2Source|GeneCards
AA969267
U43916EMP1epithelial membrane protein 1Source|GeneCards
AL080146
M34641FGFR1fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)Source|GeneCards
X73066NME1non-metastatic cells 1, protein (NM23A) expressed inSource|GeneCards
U13695PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)Source|GeneCards
X01057IL2RAinterleukin 2 receptor, alphaSource|GeneCards
AF020038IDH1isocitrate dehydrogenase 1 (NADP+), solubleSource|GeneCards
U10886PTPRJprotein tyrosine phosphatase, receptor type, JSource|GeneCards
AL080181IGSF4immunoglobulin superfamily, member 4Source|GeneCards
U56833VBP1von Hippel-Lindau binding protein 1Source|GeneCards
D38522
U01038PLK1polo-like kinase 1 (Drosophila)Source|GeneCards
U88964ISG20interferon stimulated gene 20kDaSource|GeneCards
AB028975CEP164KIAA1052 proteinSource|GeneCards
AJ000480TRIB1tribbles homolog 1 (Drosophila)Source|GeneCards
D38251POLR2Epolymerase (RNA) II (DNA directed) polypeptide E, 25kDaSource|GeneCards
M34423GLB1galactosidase, beta 1Source|GeneCards
U37689POLR2Hpolymerase (RNA) II (DNA directed) polypeptide HSource|GeneCards
AC005253
Z70519FASFas (TNF receptor superfamily, member 6)Source|GeneCards
X74008PPP1CCprotein phosphatase 1, catalytic subunit, gamma isoformSource|GeneCards
AI347088
AI127424
U91932AP3S1adaptor-related protein complex 3, sigma 1 subunitSource|GeneCards
AB007455TP53AP1TP53 activated protein 1Source|GeneCards
AB024704TPX2TPX2, microtubule-associated protein homolog (Xenopus laevis)Source|GeneCards
U86529GSTZ1glutathione transferase zeta 1 (maleylacetoacetate isomerase)Source|GeneCards
M63838IFI16interferon, gamma-inducible protein 16Source|GeneCards
D13633DLG7discs, large homolog 7 (Drosophila)Source|GeneCards
Y11525
X62534HMGB2high-mobility group box 2Source|GeneCards
M13228
S57501PPP1CAprotein phosphatase 1, catalytic subunit, alpha isoformSource|GeneCards
J03133
J04088TOP2Atopoisomerase (DNA) II alpha 170kDaSource|GeneCards
AL080121
AF030107
AA310786
U63809PAWRPRKC, apoptosis, WT1, regulatorSource|GeneCards
U90549HMGN4high mobility group nucleosomal binding domain 4Source|GeneCards
AF022797KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4Source|GeneCards
D00017ANXA2annexin A2Source|GeneCards
M19481FSTfollistatinSource|GeneCards
AL022398
J05614PCNAproliferating cell nuclear antigenSource|GeneCards
L47276TOP2Atopoisomerase (DNA) II alpha 170kDaSource|GeneCards
X58288PTPRMprotein tyrosine phosphatase, receptor type, MSource|GeneCards
D26155SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
U74612FOXM1forkhead box M1Source|GeneCards
AF054825VAMP5vesicle-associated membrane protein 5 (myobrevin)Source|GeneCards
AF016898BATFbasic leucine zipper transcription factor, ATF-likeSource|GeneCards
U73379UBE2Cubiquitin-conjugating enzyme E2CSource|GeneCards
AA203213
X51688CCNA2cyclin A2Source|GeneCards
M87284OAS22'-5'-oligoadenylate synthetase 2, 69/71kDaSource|GeneCards
AF053306BUB1BBUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)Source|GeneCards
M81830SSTR2somatostatin receptor 2Source|GeneCards
X65233ZNF80zinc finger protein 80 (pT17)Source|GeneCards
AB020316USTuronyl-2-sulfotransferaseSource|GeneCards
AJ010953ATP2C1ATPase, Ca++ transporting, type 2C, member 1Source|GeneCards
AF009426C18ORF1chromosome 18 open reading frame 1Source|GeneCards
Y11681MRPS12mitochondrial ribosomal protein S12Source|GeneCards
D26361KIF14kinesin family member 14Source|GeneCards
M74089LOC91137hypothetical protein BC017169Source|GeneCards
U81561PTPRN2protein tyrosine phosphatase, receptor type, N polypeptide 2Source|GeneCards
L07541RFC3replication factor C (activator 1) 3, 38kDaSource|GeneCards
AI056696
J03473PARP1poly (ADP-ribose) polymerase family, member 1Source|GeneCards
AB018271DSTdystoninSource|GeneCards
U78190GCHFRGTP cyclohydrolase I feedback regulatory proteinSource|GeneCards
AF087036MSCmusculin (activated B-cell factor-1)Source|GeneCards
D44497CORO1Acoronin, actin binding protein, 1ASource|GeneCards
AA056747
M97935STAT1signal transducer and activator of transcription 1, 91kDaSource|GeneCards
X64624POU4F1POU domain, class 4, transcription factor 1Source|GeneCards
AC003108
D13643DHCR2424-dehydrocholesterol reductaseSource|GeneCards
Y00664
AB018270MYO1Dmyosin IDSource|GeneCards
L23959TFDP1transcription factor Dp-1Source|GeneCards
U30872CENPFcentromere protein F, 350/400ka (mitosin)Source|GeneCards
M97676MSX1msh homeo box homolog 1 (Drosophila)Source|GeneCards
U37426KIF11kinesin family member 11Source|GeneCards
M87339RFC4replication factor C (activator 1) 4, 37kDaSource|GeneCards
AB012911FZD6frizzled homolog 6 (Drosophila)Source|GeneCards
U03494TFCP2transcription factor CP2Source|GeneCards
AI566877
M11507TFRCtransferrin receptor (p90, CD71)Source|GeneCards
AI652660
U50079HDAC1histone deacetylase 1Source|GeneCards
AF000416EXTL2exostoses (multiple)-like 2Source|GeneCards
AB013452ATP8A1ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1Source|GeneCards
M87434OAS22'-5'-oligoadenylate synthetase 2, 69/71kDaSource|GeneCards
AA005018
D50692MYCBPc-myc binding proteinSource|GeneCards
L25876CDKN3cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)Source|GeneCards
U31601JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)Source|GeneCards
X84194ACYP1acylphosphatase 1, erythrocyte (common) typeSource|GeneCards
D50920THRAP4thyroid hormone receptor associated protein 4Source|GeneCards
M63488
U25182PRDX4peroxiredoxin 4Source|GeneCards
AL050107WWTR1WW domain containing transcription regulator 1Source|GeneCards
X00948RLN2relaxin 2 (H2)Source|GeneCards
J03802PTHLHparathyroid hormone-like hormoneSource|GeneCards
U76638BARD1BRCA1 associated RING domain 1Source|GeneCards
D87119TRIB2tribbles homolog 2 (Drosophila)Source|GeneCards
AL109672TMED3transmembrane emp24 domain containing 3Source|GeneCards
AA255502
X65550MKI67antigen identified by monoclonal antibody Ki-67Source|GeneCards
D86062C21ORF33chromosome 21 open reading frame 33Source|GeneCards
U53003C21ORF33chromosome 21 open reading frame 33Source|GeneCards
AB002305ARNT2aryl-hydrocarbon receptor nuclear translocator 2Source|GeneCards
AF053551MTX2metaxin 2Source|GeneCards
AF070523ARL6IP5ADP-ribosylation-like factor 6 interacting protein 5Source|GeneCards
X14798ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
AF006084ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDaSource|GeneCards
L09235ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit ASource|GeneCards
M15024MYBv-myb myeloblastosis viral oncogene homolog (avian)Source|GeneCards
X67951PRDX1peroxiredoxin 1Source|GeneCards
AC004528
D78261IRF4interferon regulatory factor 4Source|GeneCards
D28364ANXA2annexin A2Source|GeneCards
AI540958
AB007447TRAFD1TRAF-type zinc finger domain containing 1Source|GeneCards
D14657KIAA0101KIAA0101 gene productSource|GeneCards
AF024714AIM2absent in melanoma 2Source|GeneCards
AI375913
X74262RBBP4retinoblastoma binding protein 4Source|GeneCards
D42055NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
U49089
X69398CD47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)Source|GeneCards
AF079529PDE8Bphosphodiesterase 8BSource|GeneCards
M63573PPIBpeptidylprolyl isomerase B (cyclophilin B)Source|GeneCards
AF064084ICMTisoprenylcysteine carboxyl methyltransferaseSource|GeneCards
LI3435
AA919102
M36711TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)Source|GeneCards
M15205TK1thymidine kinase 1, solubleSource|GeneCards
M23379
L42243IFNAR2interferon (alpha, beta and omega) receptor 2Source|GeneCards
AF007155LOC254531PlSC domain containing hypothetical proteinSource|GeneCards
AB024401ING1inhibitor of growth family, member 1Source|GeneCards
D37984RECQLRecQ protein-like (DNA helicase Q1-like)Source|GeneCards
D00596TYMSthymidylate synthetaseSource|GeneCards
D26599PSMB2proteasome (prosome, macropain) subunit, beta type, 2Source|GeneCards
X72889SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
M37712GPR125G protein-coupled receptor 125Source|GeneCards
W26466
M13755G1P2interferon, alpha-inducible protein (clone IFI-15K)Source|GeneCards
D63861PPIDpeptidylprolyl isomerase D (cyclophilin D)Source|GeneCards
X57398NOMO1NODAL modulator 3Source|GeneCards
X02883
AL050069DOK5docking protein 5Source|GeneCards
U51004HINT1histidine triad nucleotide binding protein 1Source|GeneCards
X83490FASFas (TNF receptor superfamily, member 6)Source|GeneCards
AA811338
AF042384CHMP2Achromatin modifying protein 2ASource|GeneCards
U09564SRPK1SFRS protein kinase 1Source|GeneCards
U32849NMIN-myc (and STAT) interactorSource|GeneCards
U09813ATP5G3ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3Source|GeneCards
U29332FHL2four and a half LIM domains 2Source|GeneCards
AJ000534SGCEsarcoglycan, epsilonSource|GeneCards
AF055993SAP30sin3-associated polypeptide, 30kDaSource|GeneCards
AL050034PARP3poly (ADP-ribose) polymerase family, member 3Source|GeneCards
M25280SELLselectin L (lymphocyte adhesion molecule 1)Source|GeneCards
X98248KLHDC3kelch domain containing 3Source|GeneCards
AF070648CAV1caveolin 1, caveolae protein, 22kDaSource|GeneCards
AJ245416LSM2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)Source|GeneCards
D14710ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscleSource|GeneCards
AJ001612PSPHLphosphoserine phosphatase-likeSource|GeneCards
AF022385PDCD10programmed cell death 10Source|GeneCards
AI760162
U38545
M25753CCNB1cyclin B1Source|GeneCards
AF067656ZWINTZW10 interactorSource|GeneCards
M86699TTKTTK protein kinaseSource|GeneCards
J04058ETFAelectron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II)Source|GeneCards
J00314
U16799ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptideSource|GeneCards
AL031737
D38073MCM3MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)Source|GeneCards
AF150241


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