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Gene set: WNT_SW480_UP (C2:PERT:0144)
Standard nameWNT_SW480_UP
Systematic nameC2:PERT:0144
Brief descriptionGenes up-regulated by APC in SW480 (colon cancer)
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
To elucidate the molecular mechanism of colorectal carcinogenesis,
we have been attempting to isolate genes involved in the beta-catenin/T-cell
factor pathway. In the experiments reported here, analysis by
cDNA microarray indicated that AF17, a fusion partner of the MLL
gene in acute leukemias with t(11;17)(q23;q21), was transactivated
according to accumulation of beta-catenin. Expression of AF17
was significantly enhanced in 8 of the 12 colorectal cancer tissues
examined. Introduction of a plasmid designed to express AF17 stimulated
growth of NIH3T3 cells, and fluorescence-activated cell sorter
analysis indicated that the AF17 regulation of cell-cycle progression
was occurring mainly at the G(2)-M transition. Our results suggest
that the AF17 gene product is likely to be involved in the beta-catenin-T-cell
factor/lymphoid enhancer factor signaling pathway and to function
as a growth-promoting, oncogenic protein. These findings should
aid development of new strategies for diagnosis, treatment, and
prevention of colon cancers and acute leukemias by clarifying
the pathogenesis of these conditions. 
Publication URL11522623
External linksna
Keywords & MeSH headingsOligonucleotide Array Sequence Analysis,Transfection,Neoplasm Proteins,Cell Division/physiology,Tumor Cells,COS Cells,Trans-Activation (Genetics),Signal Transduction/physiology,Cytoskeletal Proteins,genetics,Genetic,Mice,Transcription Factors,Cultured,metabolism,Colorectal Neoplasms,Transcription,Animals,DNA-Binding Proteins,Humans,pathology,Cell Cycle/physiology,Cercopithecus aethiops,physiology,Trans-Activators,biosynthesis
OrganismHuman
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

56 genes, 56 accessions (Toggle view)

GeneTitleLinks
ATP6V0A1ATPase, H+ transporting, lysosomal V0 subunit a isoform 1Source|GeneCards
POLR2Epolymerase (RNA) II (DNA directed) polypeptide E, 25kDaSource|GeneCards
CENTB1centaurin, beta 1Source|GeneCards
FLOT2flotillin 2Source|GeneCards
SF3A1splicing factor 3a, subunit 1, 120kDaSource|GeneCards
HDGFhepatoma-derived growth factor (high-mobility group protein 1-like)Source|GeneCards
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)Source|GeneCards
TCF20transcription factor 20 (AR1)Source|GeneCards
CAPN1calpain 1, (mu/I) large subunitSource|GeneCards
HMG20Bhigh-mobility group 20BSource|GeneCards
CPSF4cleavage and polyadenylation specific factor 4, 30kDaSource|GeneCards
MAP3K11mitogen-activated protein kinase kinase kinase 11Source|GeneCards
AGRNagrinSource|GeneCards
GLTSCR2glioma tumor suppressor candidate region gene 2Source|GeneCards
CD99CD99 antigenSource|GeneCards
PFN1profilin 1Source|GeneCards
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
INE1inactivation escape 1Source|GeneCards
ACTN4actinin, alpha 4Source|GeneCards
GNA12guanine nucleotide binding protein (G protein) alpha 12Source|GeneCards
IFITM1interferon induced transmembrane protein 1 (9-27)Source|GeneCards
EVA1epithelial V-like antigen 1Source|GeneCards
PDAP1PDGFA associated protein 1Source|GeneCards
LOC492304putative insulin-like growth factor II associated proteinSource|GeneCards
RAB1BRAB1B, member RAS oncogene familySource|GeneCards
CTDSPLCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-likeSource|GeneCards
ARHGDIARho GDP dissociation inhibitor (GDI) alphaSource|GeneCards
PRKCSHprotein kinase C substrate 80K-HSource|GeneCards
SYKspleen tyrosine kinaseSource|GeneCards
ALG3asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)Source|GeneCards
MMP14matrix metalloproteinase 14 (membrane-inserted)Source|GeneCards
PCDH9protocadherin 9Source|GeneCards
PKP3plakophilin 3Source|GeneCards
GJB1gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)Source|GeneCards
HNRPUL1heterogeneous nuclear ribonucleoprotein U-like 1Source|GeneCards
SLC1A5solute carrier family 1 (neutral amino acid transporter), member 5Source|GeneCards
RPL39Lribosomal protein L39-likeSource|GeneCards
CCND1cyclin D1 (PRAD1: parathyroid adenomatosis 1)Source|GeneCards
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)Source|GeneCards
MTA1metastasis associated 1Source|GeneCards
ZBTB7Azinc finger and BTB domain containing 7ASource|GeneCards
LMNAlamin A/CSource|GeneCards
KRT7keratin 7Source|GeneCards
HSPE1heat shock 10kDa protein 1 (chaperonin 10)Source|GeneCards
EIF5Aeukaryotic translation initiation factor 5ASource|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
BCAP31B-cell receptor-associated protein 31Source|GeneCards
PCNAproliferating cell nuclear antigenSource|GeneCards
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDaSource|GeneCards
HNRPA0heterogeneous nuclear ribonucleoprotein A0Source|GeneCards
SCAPSREBP CLEAVAGE-ACTIVATING PROTEINSource|GeneCards
KIAA0683KIAA0683 gene productSource|GeneCards
AESamino-terminal enhancer of splitSource|GeneCards
KRT5keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)Source|GeneCards
UBE1ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)Source|GeneCards
IMPDH2IMP (inosine monophosphate) dehydrogenase 2Source|GeneCards


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