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Gene set: AML1_ETO_ROSS (C2:PERT:0047)
Standard nameAML1_ETO_ROSS
Systematic nameC2:PERT:0047
Brief descriptionGenes that distinguish pediatric acute myeloid leukemia (AML) subtype t(8;21)[AML1-ETO].
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Contemporary treatment of pediatric acute myeloid leukemia (AML)
requires the assignment of patients to specific risk groups. To
explore whether expression profiling of leukemic blasts could
accurately distinguish between the known risk groups of AML, we
analyzed 130 pediatric and 20 adult AML diagnostic bone marrow
or peripheral blood samples using the Affymetrix U133A microarray.
Class discriminating genes were identified for each of the major
prognostic subtypes of pediatric AML, including t(15;17)[PML-RARalpha],
t(8;21)[AML1-ETO], inv(16) [CBFbeta-MYH11], MLL chimeric fusion
genes, and cases classified as FAB-M7. When subsets of these genes
were used in supervised learning algorithms, an overall classification
accuracy of more than 93% was achieved. Moreover, we were able
to use the expression signatures generated from the pediatric
samples to accurately classify adult de novo AMLs with the same
genetic lesions. The class discriminating genes also provided
novel insights into the molecular pathobiology of these leukemias.
Finally, using a combined pediatric data set of 130 AMLs and 137
acute lymphoblastic leukemias, we identified an expression signature
for cases with MLL chimeric fusion genes irrespective of lineage.
Surprisingly, AMLs containing partial tandem duplications of MLL
failed to cluster with MLL chimeric fusion gene cases, suggesting
a significant difference in their underlying mechanism of transformation.
Publication URL15226186
External linksna
Keywords & MeSH headingsTranscription Factors/genetics,Prognosis,Acute,Gene Expression Profiling,P.H.S.,classification,Oncogene Proteins,Proto-Oncogenes/genetics,Risk Factors,Blood,Fusion/genetics,Humans,Leukemia,genetics,Myelocytic,Child,DNA-Binding Proteins/genetics,Cluster Analysis,Algorithms,Tandem Repeat Sequences,Bone Marrow
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

80 genes, 100 accessions (Toggle view)

AccessionGeneTitleLinks
214853_s_atSHC1SHC (Src homology 2 domain containing) transforming protein 1Source|GeneCards
212495_atJMJD2Bjumonji domain containing 2BSource|GeneCards
219201_s_atTWSG1twisted gastrulation homolog 1 (Drosophila)Source|GeneCards
204495_s_atDKFZP434H132DKFZP434H132 proteinSource|GeneCards
208523_x_atHIST1H2BIhistone 1, H2biSource|GeneCards
204494_s_atDKFZP434H132DKFZP434H132 proteinSource|GeneCards
201721_s_atLAPTM5lysosomal associated multispanning membrane protein 5Source|GeneCards
205101_atMHC2TAMHC class II transactivatorSource|GeneCards
218557_atNIT2nitrilase family, member 2Source|GeneCards
206940_s_atPOU4F1POU domain, class 4, transcription factor 1Source|GeneCards
212370_x_atFAM21B /// LOC387680family with sequence similarity 21, member B /// similar to KIAA0592 proteinSource|GeneCards
212706_atRASA4 /// FLJ21767RAS p21 protein activator 4 /// hypothetical protein FLJ21767Source|GeneCards
202006_atPTPN12protein tyrosine phosphatase, non-receptor type 12Source|GeneCards
216832_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
220606_s_atMDS006x 006 proteinSource|GeneCards
221760_atMAN1A1Mannosidase, alpha, class 1A, member 1Source|GeneCards
216831_s_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
218613_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
209911_x_atHIST1H2BDhistone 1, H2bdSource|GeneCards
211323_s_atITPR1inositol 1,4,5-triphosphate receptor, type 1Source|GeneCards
218486_atKLF11Kruppel-like factor 11Source|GeneCards
218742_atNARFLnuclear prelamin A recognition factor-likeSource|GeneCards
206855_s_atHYAL2hyaluronoglucosaminidase 2Source|GeneCards
204073_s_atC11ORF9chromosome 11 open reading frame 9Source|GeneCards
221257_x_atFBXO38F-box protein 38 /// F-box protein 38Source|GeneCards
206147_x_atSCML2sex comb on midleg-like 2 (Drosophila)Source|GeneCards
209539_atARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6Source|GeneCards
218825_atEGFL7EGF-like-domain, multiple 7Source|GeneCards
204319_s_atRGS10regulator of G-protein signalling 10Source|GeneCards
218899_s_atBAALCbrain and acute leukemia, cytoplasmicSource|GeneCards
206726_atPGDSprostaglandin D2 synthase, hematopoieticSource|GeneCards
211685_s_atNCALDneurocalcin delta /// neurocalcin deltaSource|GeneCards
211517_s_atIL5RAinterleukin 5 receptor, alphaSource|GeneCards
205423_atAP1B1adaptor-related protein complex 1, beta 1 subunitSource|GeneCards
214946_x_atFAM21B /// FAM21C //proteinSource|GeneCards
218352_atRCBTB1regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1Source|GeneCards
204086_atPRAMEpreferentially expressed antigen in melanomaSource|GeneCards
208116_s_atMAN1A1mannosidase, alpha, class 1A, member 1Source|GeneCards
216942_s_atCD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
212929_s_atFAM21B /// FAM21C //proteinSource|GeneCards
212707_s_atRASA4 /// FLJ21767RAS p21 protein activator 4 /// hypothetical protein FLJ21767Source|GeneCards
208546_x_atHIST1H2BHhistone 1, H2bhSource|GeneCards
219132_atPELI2pellino homolog 2 (Drosophila)Source|GeneCards
205528_s_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
212573_atKIAA0830KIAA0830 proteinSource|GeneCards
203859_s_atPALMparalemminSource|GeneCards
216356_x_atBAIAP3BAI1-associated protein 3Source|GeneCards
211068_x_atFAM21C /// LOC439973proteinSource|GeneCards
219911_s_atSLCO4A1solute carrier organic anion transporter family, member 4A1Source|GeneCards
206398_s_atCD19CD19 antigenSource|GeneCards
218205_s_atMKNK2MAP kinase interacting serine/threonine kinase 2Source|GeneCards
212097_atCAV1caveolin 1, caveolae protein, 22kDaSource|GeneCards
218332_atBEX1brain expressed, X-linked 1Source|GeneCards
209543_s_atCD34CD34 antigenSource|GeneCards
208885_atLCP1lymphocyte cytosolic protein 1 (L-plastin)Source|GeneCards
205513_atTCN1transcobalamin I (vitamin B12 binding protein, R binder family)Source|GeneCards
204990_s_atITGB4integrin, beta 4Source|GeneCards
203355_s_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
220307_atCD244CD244 natural killer cell receptor 2B4Source|GeneCards
208091_s_atECOPEGFR-coamplified and overexpressed protein /// EGFR-coamplified and overexpressed proteinSource|GeneCards
205173_x_atCD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
203379_atRPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 1Source|GeneCards
208490_x_atHIST1H2BFhistone 1, H2bfSource|GeneCards
219752_atRASAL1RAS protein activator like 1 (GAP1 like)Source|GeneCards
33304_atISG20interferon stimulated exonuclease gene 20kDaSource|GeneCards
214349_atNA
201281_atADRM1adhesion regulating molecule 1Source|GeneCards
206187_atPTGIRprostaglandin I2 (prostacyclin) receptor (IP)Source|GeneCards
206090_s_atDISC1disrupted in schizophrenia 1Source|GeneCards
210010_s_atSLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1Source|GeneCards
204811_s_atCACNA2D2calcium channel, voltage-dependent, alpha 2/delta subunit 2Source|GeneCards
211341_atPOU4F1POU domain, class 4, transcription factor 1Source|GeneCards
212492_s_atJMJD2Bjumonji domain containing 2BSource|GeneCards
219686_atSTK32Bserine/threonine kinase 32BSource|GeneCards
202081_atIER2immediate early response 2Source|GeneCards
213194_atROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)Source|GeneCards
218858_atDEPDC6DEP domain containing 6Source|GeneCards
212496_s_atJMJD2Bjumonji domain containing 2BSource|GeneCards
205529_s_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
204929_s_atVAMP5vesicle-associated membrane protein 5 (myobrevin)Source|GeneCards
221581_s_atLAT2linker for activation of T cells family, member 2Source|GeneCards
201720_s_atLAPTM5lysosomal associated multispanning membrane protein 5Source|GeneCards
217795_s_atTMEM43transmembrane protein 43Source|GeneCards
210744_s_atIL5RAinterleukin 5 receptor, alphaSource|GeneCards
208712_atCCND1cyclin D1 (PRAD1: parathyroid adenomatosis 1)Source|GeneCards
203065_s_atCAV1caveolin 1, caveolae protein, 22kDaSource|GeneCards
209137_s_atUSP10ubiquitin specific protease 10Source|GeneCards
211744_s_atCD58CD58 antigen, (lymphocyte function-associated antigen 3) /// CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
215411_s_atTRAF3IP2TRAF3 interacting protein 2Source|GeneCards
206622_atTRHthyrotropin-releasing hormoneSource|GeneCards
204698_atISG20interferon stimulated exonuclease gene 20kDaSource|GeneCards
219890_atCLEC5AC-type lectin domain family 5, member ASource|GeneCards
219478_atWFDC1WAP four-disulfide core domain 1Source|GeneCards
336_atTBXA2Rthromboxane A2 receptorSource|GeneCards
210377_atSAHSA hypertension-associated homolog (rat)Source|GeneCards
222067_x_atHIST1H2BDhistone 1, H2bdSource|GeneCards
222061_atCD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
219255_x_atIL17RBinterleukin 17 receptor BSource|GeneCards
202117_atARHGAP1Rho GTPase activating protein 1Source|GeneCards
201839_s_atTACSTD1tumor-associated calcium signal transducer 1Source|GeneCards


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