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Gene set: BMYB_MORPHOLINO_UP_IN_CNT_SHEPARD (C2:MODL:0003)
Standard nameBMYB_MORPHOLINO_UP_IN_CNT_SHEPARD
Systematic nameC2:MODL:0003
Brief descriptionGenes upregulated in control vs bmyb morpholino knockdown in zebra fish
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

208 genes, 208 accessions (Toggle view)

GeneTitleLinks
AURKBaurora kinase BSource|GeneCards
PRC1protein regulator of cytokinesis 1Source|GeneCards
APOEapolipoprotein ESource|GeneCards
SULF1sulfatase 1Source|GeneCards
C8Gcomplement component 8, gamma polypeptideSource|GeneCards
CEBPDCCAAT/enhancer binding protein (C/EBP), deltaSource|GeneCards
NR0B2nuclear receptor subfamily 0, group B, member 2Source|GeneCards
TACC3transforming, acidic coiled-coil containing protein 3Source|GeneCards
CDCA3cell division cycle associated 3Source|GeneCards
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
CKAP2cytoskeleton associated protein 2Source|GeneCards
CDK2cyclin-dependent kinase 2Source|GeneCards
ACAT2acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)Source|GeneCards
TGM1transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)Source|GeneCards
NUMA1nuclear mitotic apparatus protein 1Source|GeneCards
SYNGR1synaptogyrin 1Source|GeneCards
GMNNgeminin, DNA replication inhibitorSource|GeneCards
PYGLphosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)Source|GeneCards
BMS1LBMS1-like, ribosome assembly protein (yeast)Source|GeneCards
DHFRdihydrofolate reductaseSource|GeneCards
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)Source|GeneCards
FBXO5F-box only protein 5Source|GeneCards
IQGAP3IQ motif containing GTPase activating protein 3Source|GeneCards
MYH8myosin, heavy polypeptide 8, skeletal muscle, perinatalSource|GeneCards
FLJ12547hypothetical protein FLJ12547Source|GeneCards
ASCL1achaete-scute complex-like 1 (Drosophila)Source|GeneCards
MAB21L2mab-21-like 2 (C. elegans)Source|GeneCards
C17ORF37chromosome 17 open reading frame 37 /// chromosome 17 open reading frame 37Source|GeneCards
PAXIP1LPAX transcription activation domain interacting protein 1 likeSource|GeneCards
DUTdUTP pyrophosphataseSource|GeneCards
PRKCB1protein kinase C, beta 1Source|GeneCards
TNXBtenascin XBSource|GeneCards
PRIM1primase, polypeptide 1, 49kDaSource|GeneCards
LIPGlipase, endothelialSource|GeneCards
CDCA2cell division cycle associated 2Source|GeneCards
ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
PCDH18protocadherin 18Source|GeneCards
UHRF1ubiquitin-like, containing PHD and RING finger domains, 1Source|GeneCards
NDE1nudE nuclear distribution gene E homolog 1 (A. nidulans)Source|GeneCards
NSD1nuclear receptor binding SET domain protein 1Source|GeneCards
CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
PDCLphosducin-likeSource|GeneCards
MELKmaternal embryonic leucine zipper kinaseSource|GeneCards
DAPdeath-associated proteinSource|GeneCards
MT2Ametallothionein 2ASource|GeneCards
TK1thymidine kinase 1, solubleSource|GeneCards
HMGA1high mobility group AT-hook 1Source|GeneCards
GTSE1G-2 and S-phase expressed 1Source|GeneCards
NR2F1nuclear receptor subfamily 2, group F, member 1Source|GeneCards
POU3F2POU domain, class 3, transcription factor 2Source|GeneCards
HLX1H2.0-like homeo box 1 (Drosophila)Source|GeneCards
LOC112817hypothetical protein BC011916Source|GeneCards
RTKNrhotekinSource|GeneCards
POU3F3POU domain, class 3, transcription factor 3Source|GeneCards
DLX2distal-less homeo box 2Source|GeneCards
GRHPRglyoxylate reductase/hydroxypyruvate reductaseSource|GeneCards
SCINscinderinSource|GeneCards
HELLShelicase, lymphoid-specificSource|GeneCards
KRT2Akeratin 2A (epidermal ichthyosis bullosa of Siemens)Source|GeneCards
CHERPcalcium homeostasis endoplasmic reticulum proteinSource|GeneCards
SOX21SRY (sex determining region Y)-box 21Source|GeneCards
DLX1distal-less homeo box 1Source|GeneCards
MKI67antigen identified by monoclonal antibody Ki-67Source|GeneCards
ANLNanillin, actin binding protein (scraps homolog, Drosophila)Source|GeneCards
FLJ20920hypothetical protein FLJ20920Source|GeneCards
EOMESeomesodermin homolog (Xenopus laevis)Source|GeneCards
APOA4apolipoprotein A-IVSource|GeneCards
ORC4Lorigin recognition complex, subunit 4-like (yeast)Source|GeneCards
LHX1LIM homeobox 1Source|GeneCards
PVALBparvalbuminSource|GeneCards
ACAS2acetyl-Coenzyme A synthetase 2 (ADP forming)Source|GeneCards
TPX2TPX2, microtubule-associated protein homolog (Xenopus laevis)Source|GeneCards
PSAT1phosphoserine aminotransferase 1Source|GeneCards
SFRS9splicing factor, arginine/serine-rich 9Source|GeneCards
ATP1A1ATPase, Na+/K+ transporting, alpha 1 polypeptideSource|GeneCards
TTKTTK protein kinaseSource|GeneCards
GALCgalactosylceramidase (Krabbe disease)Source|GeneCards
C14ORF4chromosome 14 open reading frame 4Source|GeneCards
PLP1proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)Source|GeneCards
SFXN2sideroflexin 2Source|GeneCards
KRT17keratin 17Source|GeneCards
FGGfibrinogen, gamma polypeptideSource|GeneCards
TCN2transcobalamin II; macrocytic anemiaSource|GeneCards
TXNIPthioredoxin interacting proteinSource|GeneCards
HEY1hairy/enhancer-of-split related with YRPW motif 1Source|GeneCards
KIF11kinesin family member 11Source|GeneCards
TM7SF2transmembrane 7 superfamily member 2Source|GeneCards
NOTCH2Notch homolog 2 (Drosophila)Source|GeneCards
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4Source|GeneCards
F7coagulation factor VII (serum prothrombin conversion accelerator)Source|GeneCards
CLDN1claudin 1Source|GeneCards
FLJ11029hypothetical protein FLJ11029Source|GeneCards
EDG1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1Source|GeneCards
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)Source|GeneCards
MDM4Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)Source|GeneCards
RGS2regulator of G-protein signalling 2, 24kDaSource|GeneCards
SARDHsarcosine dehydrogenaseSource|GeneCards
RGS4regulator of G-protein signalling 4Source|GeneCards
SFRP1secreted frizzled-related protein 1Source|GeneCards
C22ORF18chromosome 22 open reading frame 18Source|GeneCards
FGAfibrinogen, A alpha polypeptideSource|GeneCards
CA1carbonic anhydrase ISource|GeneCards
MCM5MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)Source|GeneCards
NR2E1nuclear receptor subfamily 2, group E, member 1Source|GeneCards
AQP1aquaporin 1 (channel-forming integral protein, 28kDa)Source|GeneCards
CDC6CDC6 cell division cycle 6 homolog (S. cerevisiae)Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
KAL1Kallmann syndrome 1 sequenceSource|GeneCards
BHLHB5basic helix-loop-helix domain containing, class B, 5Source|GeneCards
MCM4MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)Source|GeneCards
BFB-factor, properdinSource|GeneCards
TTNtitinSource|GeneCards
CCNG2cyclin G2Source|GeneCards
KIF23kinesin family member 23Source|GeneCards
AQP3aquaporin 3Source|GeneCards
RAXretina and anterior neural fold homeoboxSource|GeneCards
DCKdeoxycytidine kinaseSource|GeneCards
UCP2uncoupling protein 2 (mitochondrial, proton carrier)Source|GeneCards
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Source|GeneCards
TNRC9trinucleotide repeat containing 9Source|GeneCards
IGFBP2insulin-like growth factor binding protein 2, 36kDaSource|GeneCards
MGAT4Bmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme BSource|GeneCards
MCM2MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)Source|GeneCards
ARID5BAT rich interactive domain 5B (MRF1-like)Source|GeneCards
AEBP1AE binding protein 1Source|GeneCards
FGFR4fibroblast growth factor receptor 4Source|GeneCards
COTL1coactosin-like 1 (Dictyostelium)Source|GeneCards
ITGB4integrin, beta 4Source|GeneCards
GCH1GTP cyclohydrolase 1 (dopa-responsive dystonia)Source|GeneCards
FLJ20641hypothetical protein FLJ20641Source|GeneCards
SOX11SRY (sex determining region Y)-box 11Source|GeneCards
CTSLcathepsin LSource|GeneCards
PMP22peripheral myelin protein 22Source|GeneCards
LOC55924hypothetical protein LOC55924Source|GeneCards
NOVA2neuro-oncological ventral antigen 2Source|GeneCards
SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Source|GeneCards
GPT2glutamic pyruvate transaminase (alanine aminotransferase) 2Source|GeneCards
VTNvitronectin (serum spreading factor, somatomedin B, complement S-protein)Source|GeneCards
C3complement component 3Source|GeneCards
LIG1ligase I, DNA, ATP-dependentSource|GeneCards
MASTLmicrotubule associated serine/threonine kinase-likeSource|GeneCards
CCNB3cyclin B3Source|GeneCards
SLC29A2solute carrier family 29 (nucleoside transporters), member 2Source|GeneCards
PFS2DNA replication complex GINS protein PSF2Source|GeneCards
CCNB1cyclin B1Source|GeneCards
MDKmidkine (neurite growth-promoting factor 2)Source|GeneCards
SERPINC1serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1Source|GeneCards
ASPMasp (abnormal spindle)-like, microcephaly associated (Drosophila)Source|GeneCards
DRAP1DR1-associated protein 1 (negative cofactor 2 alpha)Source|GeneCards
MGC49942hypothetical protein MGC49942Source|GeneCards
KRTHA2keratin, hair, acidic, 2Source|GeneCards
FOXM1forkhead box M1Source|GeneCards
POU3F1POU domain, class 3, transcription factor 1Source|GeneCards
PRODH2proline dehydrogenase (oxidase) 2Source|GeneCards
HNRPA2B1heterogeneous nuclear ribonucleoprotein A2/B1Source|GeneCards
DNMT1DNA (cytosine-5-)-methyltransferase 1Source|GeneCards
FABP7fatty acid binding protein 7, brainSource|GeneCards
DLG7discs, large homolog 7 (Drosophila)Source|GeneCards
KIAA0186KIAA0186 gene productSource|GeneCards
CHX10ceh-10 homeo domain containing homolog (C. elegans)Source|GeneCards
CENTB2centaurin, beta 2Source|GeneCards
KIF14kinesin family member 14Source|GeneCards
LAMP2lysosomal-associated membrane protein 2Source|GeneCards
GRIK3glutamate receptor, ionotropic, kainate 3Source|GeneCards
COL1A1collagen, type I, alpha 1Source|GeneCards
MCM3MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)Source|GeneCards
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)Source|GeneCards
PRB1Proline-rich protein BstNI subfamily 1Source|GeneCards
OTPorthopedia homolog (Drosophila)Source|GeneCards
GPSM1G-protein signalling modulator 1 (AGS3-like, C. elegans)Source|GeneCards
ARHGEF10Rho guanine nucleotide exchange factor (GEF) 10Source|GeneCards
CEBPACCAAT/enhancer binding protein (C/EBP), alphaSource|GeneCards
BIRC5baculoviral IAP repeat-containing 5 (survivin)Source|GeneCards
BLVRBbiliverdin reductase B (flavin reductase (NADPH))Source|GeneCards
CDC20CDC20 cell division cycle 20 homolog (S. cerevisiae)Source|GeneCards
COL4A5collagen, type IV, alpha 5 (Alport syndrome)Source|GeneCards
CPVLcarboxypeptidase, vitellogenic-likeSource|GeneCards
INPP4Ainositol polyphosphate-4-phosphatase, type I, 107kDaSource|GeneCards
COL1A2collagen, type I, alpha 2Source|GeneCards
RBP4retinol binding protein 4, plasmaSource|GeneCards
TOP1MTmitochondrial topoisomerase ISource|GeneCards
PTPRNprotein tyrosine phosphatase, receptor type, NSource|GeneCards
SLC4A2solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)Source|GeneCards
SLC6A13solute carrier family 6 (neurotransmitter transporter, GABA), member 13Source|GeneCards
GOLGB1golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1Source|GeneCards


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