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Gene set: BRENTANI_CELL_ADHESION (C2:EXCU:0005)
Standard nameBRENTANI_CELL_ADHESION
Systematic nameC2:EXCU:0005
Brief descriptionCancer related genes involved in cell adhesion and metalloproteinases
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

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Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
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Genes

95 genes, 95 accessions (Toggle view)

GeneTitleLinks
DSG1desmoglein 1Source|GeneCards
ITGAEintegrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)Source|GeneCards
HMMRhyaluronan-mediated motility receptor (RHAMM)Source|GeneCards
ALCAMactivated leukocyte cell adhesion moleculeSource|GeneCards
SELPSelectin P (granule membrane protein 140kDa, antigen CD62)Source|GeneCards
ICAM2intercellular adhesion molecule 2Source|GeneCards
TIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
ICAM3intercellular adhesion molecule 3Source|GeneCards
FN1fibronectin 1Source|GeneCards
MMP9matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Source|GeneCards
ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)Source|GeneCards
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)Source|GeneCards
BYSLbystin-likeSource|GeneCards
GPA33glycoprotein A33 (transmembrane)Source|GeneCards
CDH13cadherin 13, H-cadherin (heart)Source|GeneCards
NCAM1neural cell adhesion molecule 1Source|GeneCards
ITGB8integrin, beta 8Source|GeneCards
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)Source|GeneCards
TIMP1tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)Source|GeneCards
CD99CD99 antigenSource|GeneCards
SELEselectin E (endothelial adhesion molecule 1)Source|GeneCards
CDH3Cadherin 3, type 1, P-cadherin (placental)Source|GeneCards
PCDH1protocadherin 1 (cadherin-like 1)Source|GeneCards
FATFAT tumor suppressor homolog 1 (Drosophila)Source|GeneCards
PTK2PTK2 protein tyrosine kinase 2Source|GeneCards
SDC1syndecan 1Source|GeneCards
TNCTenascin C (hexabrachion)Source|GeneCards
ARHGAP6Rho GTPase activating protein 6Source|GeneCards
JUPjunction plakoglobinSource|GeneCards
CDH15cadherin 15, M-cadherin (myotubule)Source|GeneCards
SELPLGselectin P ligandSource|GeneCards
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)Source|GeneCards
TNStensinSource|GeneCards
TIMP2tissue inhibitor of metalloproteinase 2Source|GeneCards
CDH6cadherin 6, type 2, K-cadherin (fetal kidney)Source|GeneCards
ROCK1Rho-associated, coiled-coil containing protein kinase 1Source|GeneCards
NCAM2Neural cell adhesion molecule 2Source|GeneCards
ARHGAP1Rho GTPase activating protein 1Source|GeneCards
ITGB5integrin, beta 5Source|GeneCards
MCAMmelanoma cell adhesion moleculeSource|GeneCards
CDH7cadherin 7, type 2Source|GeneCards
ITGA1integrin, alpha 1Source|GeneCards
PTPRUprotein tyrosine phosphatase, receptor type, USource|GeneCards
CDH17cadherin 17, LI cadherin (liver-intestine)Source|GeneCards
ITGB7integrin, beta 7Source|GeneCards
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)Source|GeneCards
WASLWiskott-Aldrich syndrome-likeSource|GeneCards
NEO1neogenin homolog 1 (chicken)Source|GeneCards
CDH18cadherin 18, type 2Source|GeneCards
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)Source|GeneCards
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Source|GeneCards
ITGAXintegrin, alpha X (antigen CD11C (p150), alpha polypeptide)Source|GeneCards
CDH12cadherin 12, type 2 (N-cadherin 2)Source|GeneCards
CDH5cadherin 5, type 2, VE-cadherin (vascular epithelium)Source|GeneCards
MMP13matrix metalloproteinase 13 (collagenase 3)Source|GeneCards
CD44CD44 antigen (homing function and Indian blood group system)Source|GeneCards
F2Rcoagulation factor II (thrombin) receptorSource|GeneCards
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Source|GeneCards
ITGB4integrin, beta 4Source|GeneCards
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)Source|GeneCards
CD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
SERPINI2serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2Source|GeneCards
DSC3Desmocollin 3Source|GeneCards
VCAM1vascular cell adhesion molecule 1Source|GeneCards
MMP1matrix metalloproteinase 1 (interstitial collagenase)Source|GeneCards
CXCR3chemokine (C-X-C motif) receptor 3Source|GeneCards
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)Source|GeneCards
CDH2cadherin 2, type 1, N-cadherin (neuronal)Source|GeneCards
ITGA7integrin, alpha 7Source|GeneCards
ADD3adducin 3 (gamma)Source|GeneCards
ITGAMintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)Source|GeneCards
CXCL12chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)Source|GeneCards
SELLselectin L (lymphocyte adhesion molecule 1)Source|GeneCards
CD47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)Source|GeneCards
SERPINB5serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5Source|GeneCards
ANK1ankyrin 1, erythrocyticSource|GeneCards
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Source|GeneCards
IL8interleukin 8Source|GeneCards
MMP11matrix metalloproteinase 11 (stromelysin 3)Source|GeneCards
ZYXzyxinSource|GeneCards
PECAM1platelet/endothelial cell adhesion molecule (CD31 antigen)Source|GeneCards
CDH4cadherin 4, type 1, R-cadherin (retinal)Source|GeneCards
GJB2gap junction protein, beta 2, 26kDa (connexin 26)Source|GeneCards
CNTN1contactin 1Source|GeneCards
GJA4gap junction protein, alpha 4, 37kDa (connexin 37)Source|GeneCards
CDH1cadherin 1, type 1, E-cadherin (epithelial)Source|GeneCards
CD97CD97 antigenSource|GeneCards
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DSource|GeneCards
ICAM1intercellular adhesion molecule 1 (CD54), human rhinovirus receptorSource|GeneCards
DCCdeleted in colorectal carcinomaSource|GeneCards
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Source|GeneCards
ITGB2integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)Source|GeneCards
PKD1polycystic kidney disease 1 (autosomal dominant)Source|GeneCards
ITGA9integrin, alpha 9Source|GeneCards


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