[an error occurred while processing this directive]
Gene set: BRENTANI_CELL_CYCLE (C2:EXCU:0007)
Standard nameBRENTANI_CELL_CYCLE
Systematic nameC2:EXCU:0007
Brief descriptionCancer related genes involved in the cell cycle
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

Toggle abstract view

Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

86 genes, 86 accessions (Toggle view)

GeneTitleLinks
CDC2L5cell division cycle 2-like 5 (cholinesterase-related cell division controller)Source|GeneCards
E2F2E2F transcription factor 2Source|GeneCards
HUS1HUS1 checkpoint homolog (S. pombe)Source|GeneCards
FOSL1FOS-like antigen 1Source|GeneCards
SKP1AS-phase kinase-associated protein 1A (p19A)Source|GeneCards
CKS1BCDC28 protein kinase regulatory subunit 1BSource|GeneCards
ERHenhancer of rudimentary homolog (Drosophila)Source|GeneCards
CENPEcentromere protein E, 312kDaSource|GeneCards
CDK6cyclin-dependent kinase 6Source|GeneCards
CKS2CDC28 protein kinase regulatory subunit 2Source|GeneCards
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)Source|GeneCards
ORC1Lorigin recognition complex, subunit 1-like (yeast)Source|GeneCards
BTG2BTG family, member 2Source|GeneCards
CCNHcyclin HSource|GeneCards
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 2Source|GeneCards
CDK8cyclin-dependent kinase 8Source|GeneCards
FRKfyn-related kinaseSource|GeneCards
POLR3Dpolymerase (RNA) III (DNA directed) polypeptide D, 44kDaSource|GeneCards
CENPC1centromere protein C 1Source|GeneCards
CHEK1CHK1 checkpoint homolog (S. pombe)Source|GeneCards
CDC16CDC16 cell division cycle 16 homolog (S. cerevisiae)Source|GeneCards
MYCV-myc myelocytomatosis viral oncogene homolog (avian)Source|GeneCards
MXI1MAX interacting protein 1Source|GeneCards
CDC6CDC6 cell division cycle 6 homolog (S. cerevisiae)Source|GeneCards
BUB3BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)Source|GeneCards
CDC42cell division cycle 42 (GTP binding protein, 25kDa)Source|GeneCards
CDC25Acell division cycle 25ASource|GeneCards
CDC25Bcell division cycle 25BSource|GeneCards
CDK7cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)Source|GeneCards
CDK2cyclin-dependent kinase 2Source|GeneCards
CHES1checkpoint suppressor 1Source|GeneCards
NUMA1nuclear mitotic apparatus protein 1Source|GeneCards
TP73tumor protein p73Source|GeneCards
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
CCNE1cyclin E1Source|GeneCards
BUB1BBUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)Source|GeneCards
MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
CDC27cell division cycle 27Source|GeneCards
TP53tumor protein p53 (Li-Fraumeni syndrome)Source|GeneCards
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)Source|GeneCards
CDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)Source|GeneCards
CCNE2cyclin E2Source|GeneCards
CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Source|GeneCards
CDC45LCDC45 cell division cycle 45-like (S. cerevisiae)Source|GeneCards
MAXMAX proteinSource|GeneCards
ZW10ZW10 homolog, centromere/kinetochore protein (Drosophila)Source|GeneCards
CENPAcentromere protein A, 17kDaSource|GeneCards
GAS2growth arrest-specific 2Source|GeneCards
CDC37CDC37 cell division cycle 37 homolog (S. cerevisiae)Source|GeneCards
CCND2cyclin D2Source|GeneCards
CDC25Ccell division cycle 25CSource|GeneCards
CCND1cyclin D1 (PRAD1: parathyroid adenomatosis 1)Source|GeneCards
BCCIPBRCA2 and CDKN1A interacting proteinSource|GeneCards
SKP2S-phase kinase-associated protein 2 (p45)Source|GeneCards
GAS1growth arrest-specific 1Source|GeneCards
TTKTTK protein kinaseSource|GeneCards
GSPT1G1 to S phase transition 1Source|GeneCards
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)Source|GeneCards
CDC20CDC20 cell division cycle 20 homolog (S. cerevisiae)Source|GeneCards
MNAT1menage a trois 1 (CAK assembly factor)Source|GeneCards
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)Source|GeneCards
CENPFcentromere protein F, 350/400ka (mitosin)Source|GeneCards
E2F1E2F transcription factor 1Source|GeneCards
BUB1BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)Source|GeneCards
CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)Source|GeneCards
CCNA2cyclin A2Source|GeneCards
CCNFcyclin FSource|GeneCards
CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
CDC7CDC7 cell division cycle 7 (S. cerevisiae)Source|GeneCards
CDC2L1cell division cycle 2-like 1 (PITSLRE proteins)Source|GeneCards
RBL1retinoblastoma-like 1 (p107)Source|GeneCards
GADD45Bgrowth arrest and DNA-damage-inducible, betaSource|GeneCards
CDK4cyclin-dependent kinase 4Source|GeneCards
RB1retinoblastoma 1 (including osteosarcoma)Source|GeneCards
CCNB1cyclin B1Source|GeneCards
CCND3cyclin D3Source|GeneCards
MOSv-mos Moloney murine sarcoma viral oncogene homologSource|GeneCards
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Source|GeneCards
CDK5cyclin-dependent kinase 5Source|GeneCards
NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)Source|GeneCards


[an error occurred while processing this directive]