[an error occurred while processing this directive]
Gene set: BRENTANI_SIGNALLING (C2:EXCU:0015)
Standard nameBRENTANI_SIGNALLING
Systematic nameC2:EXCU:0015
Brief descriptionCancer related genes involved in the cell signaling
CategoryC2: Curated
Sub-categoryEXCU: Expert curation
Full description or Abstract

Toggle abstract view

Whereas genome sequencing defines the genetic potential of an
organism, transcript sequencing defines the utilization of this
potential and links the genome with most areas of biology. To
exploit the information within the human genome in the fight against
cancer, we have deposited some two million expressed sequence
tags (ESTs) from human tumors and their corresponding normal tissues
in the public databases. The data currently define approximately
23,500 genes, of which only approximately 1,250 are still represented
only by ESTs. Examination of the EST coverage of known cancer-related
(CR) genes reveals that <1% do not have corresponding ESTs, indicating
that the representation of genes associated with commonly studied
tumors is high. The careful recording of the origin of all ESTs
we have produced has enabled detailed definition of where the
genes they represent are expressed in the human body. More than
100,000 ESTs are available for seven tissues, indicating a surprising
variability of gene usage that has led to the discovery of a significant
number of genes with restricted expression, and that may thus
be therapeutically useful. The ESTs also reveal novel nonsynonymous
germline variants (although the one-pass nature of the data necessitates
careful validation) and many alternatively spliced transcripts.
Although widely exploited by the scientific community, vindicating
our totally open source policy, the EST data generated still provide
extensive information that remains to be systematically explored,
and that may further facilitate progress toward both the understanding
and treatment of human cancers. 
Publication URL14593198
External linksna
Keywords & MeSH headingsNeoplastic,RNA,Neoplasms,Messenger,Humans,Polymorphism,Databases,genetics,Single Nucleotide,Proteome,Genetic,Gene Expression Regulation,Variation (Genetics),Expressed Sequence Tags,Tissue Distribution,metabolism
OrganismHuman
Contributed byBroad Institute
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

198 genes, 198 accessions (Toggle view)

GeneTitleLinks
TANKTRAF family member-associated NFKB activatorSource|GeneCards
WNT5Awingless-type MMTV integration site family, member 5ASource|GeneCards
ILKintegrin-linked kinaseSource|GeneCards
CALM1calmodulin 1 (phosphorylase kinase, delta)Source|GeneCards
MAP3K8mitogen-activated protein kinase kinase kinase 8Source|GeneCards
MAP3K7IP1mitogen-activated protein kinase kinase kinase 7 interacting protein 1Source|GeneCards
SUFUsuppressor of fused homolog (Drosophila)Source|GeneCards
IL17interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)Source|GeneCards
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12Source|GeneCards
ITGA6integrin, alpha 6Source|GeneCards
PDPK13-phosphoinositide dependent protein kinase-1Source|GeneCards
FLT3LGfms-related tyrosine kinase 3 ligandSource|GeneCards
ARHGAP6Rho GTPase activating protein 6Source|GeneCards
MAPK7mitogen-activated protein kinase 7Source|GeneCards
TYK2tyrosine kinase 2Source|GeneCards
ABL2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)Source|GeneCards
ARHGAP1Rho GTPase activating protein 1Source|GeneCards
MAP2K2mitogen-activated protein kinase kinase 2Source|GeneCards
DGKQdiacylglycerol kinase, theta 110kDaSource|GeneCards
ERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
PTPRKprotein tyrosine phosphatase, receptor type, KSource|GeneCards
SYKspleen tyrosine kinaseSource|GeneCards
FYNFYN oncogene related to SRC, FGR, YESSource|GeneCards
AKAP13A kinase (PRKA) anchor protein 13Source|GeneCards
MAP3K3mitogen-activated protein kinase kinase kinase 3Source|GeneCards
NOTCH3Notch homolog 3 (Drosophila)Source|GeneCards
IFNAR2interferon (alpha, beta and omega) receptor 2Source|GeneCards
MAPK4mitogen-activated protein kinase 4Source|GeneCards
ITGA7integrin, alpha 7Source|GeneCards
MYD88myeloid differentiation primary response gene (88)Source|GeneCards
MAP2K1mitogen-activated protein kinase kinase 1Source|GeneCards
CXCL12chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)Source|GeneCards
NOTCH4Notch homolog 4 (Drosophila)Source|GeneCards
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaSource|GeneCards
AXLAXL receptor tyrosine kinaseSource|GeneCards
IL8interleukin 8Source|GeneCards
IFNAR1interferon (alpha, beta and omega) receptor 1Source|GeneCards
MAP3K4mitogen-activated protein kinase kinase kinase 4Source|GeneCards
RALBP1ralA binding protein 1Source|GeneCards
MAP2K6mitogen-activated protein kinase kinase 6Source|GeneCards
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)Source|GeneCards
MCCmutated in colorectal cancersSource|GeneCards
ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)Source|GeneCards
PTCHpatched homolog (Drosophila)Source|GeneCards
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)Source|GeneCards
ABL1v-abl Abelson murine leukemia viral oncogene homolog 1Source|GeneCards
NRASneuroblastoma RAS viral (v-ras) oncogene homologSource|GeneCards
STAT5Bsignal transducer and activator of transcription 5BSource|GeneCards
STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
ARHIras homolog gene family, member ISource|GeneCards
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)Source|GeneCards
NF1neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)Source|GeneCards
ARHGEF16Rho guanine exchange factor (GEF) 16Source|GeneCards
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Source|GeneCards
ITGA1integrin, alpha 1Source|GeneCards
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1Source|GeneCards
IL18R1interleukin 18 receptor 1Source|GeneCards
ATMataxia telangiectasia mutated (includes complementation groups A, C and D)Source|GeneCards
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)Source|GeneCards
IGFBP3insulin-like growth factor binding protein 3Source|GeneCards
NCK1NCK adaptor protein 1Source|GeneCards
APCadenomatosis polyposis coliSource|GeneCards
TTKTTK protein kinaseSource|GeneCards
SKILSKI-likeSource|GeneCards
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)Source|GeneCards
TNFSF13tumor necrosis factor (ligand) superfamily, member 13Source|GeneCards
BCRbreakpoint cluster regionSource|GeneCards
SH3BP2SH3-domain binding protein 2Source|GeneCards
BRAFv-raf murine sarcoma viral oncogene homolog B1Source|GeneCards
BTKBruton agammaglobulinemia tyrosine kinaseSource|GeneCards
TNFRSF4tumor necrosis factor receptor superfamily, member 4Source|GeneCards
SFNstratifinSource|GeneCards
MAP3K12mitogen-activated protein kinase kinase kinase 12Source|GeneCards
TNFRSF10Atumor necrosis factor receptor superfamily, member 10aSource|GeneCards
MAPK1mitogen-activated protein kinase 1Source|GeneCards
ITGA9integrin, alpha 9Source|GeneCards
IL13interleukin 13Source|GeneCards
ITGAEintegrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)Source|GeneCards
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domainSource|GeneCards
TRAF3TNF receptor-associated factor 3Source|GeneCards
RELAv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)Source|GeneCards
MAPK11mitogen-activated protein kinase 11Source|GeneCards
ITGB8integrin, beta 8Source|GeneCards
BIRC2baculoviral IAP repeat-containing 2Source|GeneCards
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDaSource|GeneCards
MAP2K7mitogen-activated protein kinase kinase 7Source|GeneCards
RGS16regulator of G-protein signalling 16Source|GeneCards
IRS1insulin receptor substrate 1Source|GeneCards
TNFRSF10Btumor necrosis factor receptor superfamily, member 10bSource|GeneCards
MAS1MAS1 oncogeneSource|GeneCards
RAP1ARAP1A, member of RAS oncogene familySource|GeneCards
TNFtumor necrosis factor (TNF superfamily, member 2)Source|GeneCards
DLG1discs, large homolog 1 (Drosophila)Source|GeneCards
AKT2v-akt murine thymoma viral oncogene homolog 2Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
IFNGinterferon, gammaSource|GeneCards
MKNK1MAP kinase-interacting serine/threonine kinase 1Source|GeneCards
IL1Binterleukin 1, betaSource|GeneCards
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homologSource|GeneCards
MAP3K14mitogen-activated protein kinase kinase kinase 14Source|GeneCards
TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)Source|GeneCards
JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)Source|GeneCards
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)Source|GeneCards
IL10interleukin 10Source|GeneCards
ITGB7integrin, beta 7Source|GeneCards
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)Source|GeneCards
ZAP70zeta-chain (TCR) associated protein kinase 70kDaSource|GeneCards
STAT5Asignal transducer and activator of transcription 5ASource|GeneCards
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Source|GeneCards
VAV1vav 1 oncogeneSource|GeneCards
PIK3C3phosphoinositide-3-kinase, class 3Source|GeneCards
TNFRSF1Atumor necrosis factor receptor superfamily, member 1ASource|GeneCards
VIPR1vasoactive intestinal peptide receptor 1Source|GeneCards
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)Source|GeneCards
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideSource|GeneCards
ITGB4integrin, beta 4Source|GeneCards
AKT1v-akt murine thymoma viral oncogene homolog 1Source|GeneCards
TNFRSF1Btumor necrosis factor receptor superfamily, member 1BSource|GeneCards
STAT2signal transducer and activator of transcription 2, 113kDaSource|GeneCards
INHAinhibin, alphaSource|GeneCards
DGKGdiacylglycerol kinase, gamma 90kDaSource|GeneCards
IFNGR1interferon gamma receptor 1Source|GeneCards
RAF1v-raf-1 murine leukemia viral oncogene homolog 1Source|GeneCards
DGKAdiacylglycerol kinase, alpha 80kDaSource|GeneCards
IL2RBinterleukin 2 receptor, betaSource|GeneCards
TYRO3TYRO3 protein tyrosine kinaseSource|GeneCards
MUSKmuscle, skeletal, receptor tyrosine kinaseSource|GeneCards
MAPK12mitogen-activated protein kinase 12Source|GeneCards
IL12RB1interleukin 12 receptor, beta 1Source|GeneCards
RANRAN, member RAS oncogene familySource|GeneCards
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-likeSource|GeneCards
CAMK4calcium/calmodulin-dependent protein kinase IVSource|GeneCards
MAPK9mitogen-activated protein kinase 9Source|GeneCards
JAK1Janus kinase 1 (a protein tyrosine kinase)Source|GeneCards
STAT1signal transducer and activator of transcription 1, 91kDaSource|GeneCards
TIAM1T-cell lymphoma invasion and metastasis 1Source|GeneCards
PTCH2patched homolog 2 (Drosophila)Source|GeneCards
GRB7growth factor receptor-bound protein 7Source|GeneCards
TRAF1TNF receptor-associated factor 1Source|GeneCards
PTK2BPTK2B protein tyrosine kinase 2 betaSource|GeneCards
PIK3CGphosphoinositide-3-kinase, catalytic, gamma polypeptideSource|GeneCards
WNT4wingless-type MMTV integration site family, member 4Source|GeneCards
ROS1v-ros UR2 sarcoma virus oncogene homolog 1 (avian)Source|GeneCards
WNT1wingless-type MMTV integration site family, member 1Source|GeneCards
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)Source|GeneCards
GRB14growth factor receptor-bound protein 14Source|GeneCards
SMOsmoothened homolog (Drosophila)Source|GeneCards
WNT2wingless-type MMTV integration site family member 2Source|GeneCards
TRAF6TNF receptor-associated factor 6Source|GeneCards
MAPK13mitogen-activated protein kinase 13Source|GeneCards
JAG1jagged 1 (Alagille syndrome)Source|GeneCards
IFNB1interferon, beta 1, fibroblastSource|GeneCards
AXIN1axin 1Source|GeneCards
ROCK1Rho-associated, coiled-coil containing protein kinase 1Source|GeneCards
CMKOR1chemokine orphan receptor 1Source|GeneCards
MAP3K5mitogen-activated protein kinase kinase kinase 5Source|GeneCards
AXIN2axin 2 (conductin, axil)Source|GeneCards
MAPK10mitogen-activated protein kinase 10Source|GeneCards
ITGB5integrin, beta 5Source|GeneCards
RELBv-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)Source|GeneCards
JAG2jagged 2Source|GeneCards
ITGAXintegrin, alpha X (antigen CD11C (p150), alpha polypeptide)Source|GeneCards
SOS1son of sevenless homolog 1 (Drosophila)Source|GeneCards
CXCL3chemokine (C-X-C motif) ligand 3Source|GeneCards
IL15interleukin 15Source|GeneCards
MAP4K4mitogen-activated protein kinase kinase kinase kinase 4Source|GeneCards
IQGAP2IQ motif containing GTPase activating protein 2Source|GeneCards
SHC1SHC (Src homology 2 domain containing) transforming protein 1Source|GeneCards
ITGAMintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)Source|GeneCards
MAPKAPK5mitogen-activated protein kinase-activated protein kinase 5Source|GeneCards
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Source|GeneCards
MPLmyeloproliferative leukemia virus oncogeneSource|GeneCards
BCL10B-cell CLL/lymphoma 10Source|GeneCards
MAP2K4mitogen-activated protein kinase kinase 4Source|GeneCards
KRAS2v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homologSource|GeneCards
RASA1RAS p21 protein activator (GTPase activating protein) 1Source|GeneCards
CXCL2chemokine (C-X-C motif) ligand 2Source|GeneCards
MAP2K3mitogen-activated protein kinase kinase 3Source|GeneCards
IRS2insulin receptor substrate 2Source|GeneCards
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)Source|GeneCards
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2Source|GeneCards
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Source|GeneCards
ITGB2integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)Source|GeneCards
MAP2K5mitogen-activated protein kinase kinase 5Source|GeneCards
PTENphosphatase and tensin homolog (mutated in multiple advanced cancers 1)Source|GeneCards


[an error occurred while processing this directive]