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Gene set: CBF_ROSS (C2:PERT:0048)
Standard nameCBF_ROSS
Systematic nameC2:PERT:0048
Brief descriptionGenes that distinguish pediatric acute myeloid leukemia (AML) core-binding factor (CBF) subtypes.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Contemporary treatment of pediatric acute myeloid leukemia (AML)
requires the assignment of patients to specific risk groups. To
explore whether expression profiling of leukemic blasts could
accurately distinguish between the known risk groups of AML, we
analyzed 130 pediatric and 20 adult AML diagnostic bone marrow
or peripheral blood samples using the Affymetrix U133A microarray.
Class discriminating genes were identified for each of the major
prognostic subtypes of pediatric AML, including t(15;17)[PML-RARalpha],
t(8;21)[AML1-ETO], inv(16) [CBFbeta-MYH11], MLL chimeric fusion
genes, and cases classified as FAB-M7. When subsets of these genes
were used in supervised learning algorithms, an overall classification
accuracy of more than 93% was achieved. Moreover, we were able
to use the expression signatures generated from the pediatric
samples to accurately classify adult de novo AMLs with the same
genetic lesions. The class discriminating genes also provided
novel insights into the molecular pathobiology of these leukemias.
Finally, using a combined pediatric data set of 130 AMLs and 137
acute lymphoblastic leukemias, we identified an expression signature
for cases with MLL chimeric fusion genes irrespective of lineage.
Surprisingly, AMLs containing partial tandem duplications of MLL
failed to cluster with MLL chimeric fusion gene cases, suggesting
a significant difference in their underlying mechanism of transformation.
Publication URL15226186
External linksna
Keywords & MeSH headingsTranscription Factors/genetics,Prognosis,Acute,Gene Expression Profiling,P.H.S.,classification,Oncogene Proteins,Proto-Oncogenes/genetics,Risk Factors,Blood,Fusion/genetics,Humans,Leukemia,genetics,Myelocytic,Child,DNA-Binding Proteins/genetics,Cluster Analysis,Algorithms,Tandem Repeat Sequences,Bone Marrow
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

82 genes, 99 accessions (Toggle view)

AccessionGeneTitleLinks
204021_s_atPURApurine-rich element binding protein ASource|GeneCards
212495_atJMJD2Bjumonji domain containing 2BSource|GeneCards
203865_s_atADARB1adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)Source|GeneCards
208978_atCRIP2cysteine-rich protein 2Source|GeneCards
204495_s_atDKFZP434H132DKFZP434H132 proteinSource|GeneCards
204494_s_atDKFZP434H132DKFZP434H132 proteinSource|GeneCards
205101_atMHC2TAMHC class II transactivatorSource|GeneCards
206940_s_atPOU4F1POU domain, class 4, transcription factor 1Source|GeneCards
208891_atDUSP6dual specificity phosphatase 6Source|GeneCards
205683_x_atTPSAB1tryptase alpha/beta 1Source|GeneCards
205760_s_atOGG18-oxoguanine DNA glycosylaseSource|GeneCards
202255_s_atSIPA1L1signal-induced proliferation-associated 1 like 1Source|GeneCards
212706_atRASA4 /// FLJ21767RAS p21 protein activator 4 /// hypothetical protein FLJ21767Source|GeneCards
216832_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
204020_atPURApurine-rich element binding protein ASource|GeneCards
211991_s_atHLA-DPA1major histocompatibility complex, class II, DP alpha 1Source|GeneCards
221760_atMAN1A1Mannosidase, alpha, class 1A, member 1Source|GeneCards
207375_s_atIL15RAinterleukin 15 receptor, alphaSource|GeneCards
216831_s_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
34210_atCD52CD52 antigen (CAMPATH-1 antigen)Source|GeneCards
218613_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
221218_s_atTPK1thiamin pyrophosphokinase 1Source|GeneCards
218742_atNARFLnuclear prelamin A recognition factor-likeSource|GeneCards
206855_s_atHYAL2hyaluronoglucosaminidase 2Source|GeneCards
206631_atPTGER2prostaglandin E receptor 2 (subtype EP2), 53kDaSource|GeneCards
212136_atATP2B4ATPase, Ca++ transporting, plasma membrane 4Source|GeneCards
200989_atHIF1Ahypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Source|GeneCards
218749_s_atSLC24A6solute carrier family 24 (sodium/potassium/calcium exchanger), member 6Source|GeneCards
218825_atEGFL7EGF-like-domain, multiple 7Source|GeneCards
203773_x_atBLVRAbiliverdin reductase ASource|GeneCards
218899_s_atBAALCbrain and acute leukemia, cytoplasmicSource|GeneCards
202370_s_atCBFBcore-binding factor, beta subunitSource|GeneCards
206726_atPGDSprostaglandin D2 synthase, hematopoieticSource|GeneCards
211031_s_atCYLN2cytoplasmic linker 2 /// cytoplasmic linker 2Source|GeneCards
211685_s_atNCALDneurocalcin delta /// neurocalcin deltaSource|GeneCards
218352_atRCBTB1regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1Source|GeneCards
204086_atPRAMEpreferentially expressed antigen in melanomaSource|GeneCards
203741_s_atADCY7adenylate cyclase 7Source|GeneCards
208116_s_atMAN1A1mannosidase, alpha, class 1A, member 1Source|GeneCards
216942_s_atCD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
205330_atMN1meningioma (disrupted in balanced translocation) 1Source|GeneCards
205528_s_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
216356_x_atBAIAP3BAI1-associated protein 3Source|GeneCards
208178_x_atTRIOtriple functional domain (PTPRF interacting)Source|GeneCards
218205_s_atMKNK2MAP kinase interacting serine/threonine kinase 2Source|GeneCards
202664_atWASPIPWiskott-Aldrich syndrome protein interacting proteinSource|GeneCards
212097_atCAV1caveolin 1, caveolae protein, 22kDaSource|GeneCards
203733_atDEXIdexamethasone-induced transcriptSource|GeneCards
209543_s_atCD34CD34 antigenSource|GeneCards
201968_s_atPGM1phosphoglucomutase 1Source|GeneCards
204990_s_atITGB4integrin, beta 4Source|GeneCards
203355_s_atPSD3pleckstrin and Sec7 domain containing 3Source|GeneCards
201137_s_atHLA-DPB1major histocompatibility complex, class II, DP beta 1Source|GeneCards
205173_x_atCD58CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
210613_s_atSYNGR1synaptogyrin 1Source|GeneCards
217023_x_atTPSAB1tryptase alpha/beta 1Source|GeneCards
207134_x_atTPSB2tryptase beta 2Source|GeneCards
33304_atISG20interferon stimulated exonuclease gene 20kDaSource|GeneCards
217989_atDHRS8dehydrogenase/reductase (SDR family) member 8Source|GeneCards
206090_s_atDISC1disrupted in schizophrenia 1Source|GeneCards
212135_s_atATP2B4ATPase, Ca++ transporting, plasma membrane 4Source|GeneCards
221865_atC9ORF91chromosome 9 open reading frame 91Source|GeneCards
210010_s_atSLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1Source|GeneCards
211341_atPOU4F1POU domain, class 4, transcription factor 1Source|GeneCards
204811_s_atCACNA2D2calcium channel, voltage-dependent, alpha 2/delta subunit 2Source|GeneCards
219686_atSTK32Bserine/threonine kinase 32BSource|GeneCards
213194_atROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)Source|GeneCards
218858_atDEPDC6DEP domain containing 6Source|GeneCards
204794_atDUSP2dual specificity phosphatase 2Source|GeneCards
205529_s_atRUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
212496_s_atJMJD2Bjumonji domain containing 2BSource|GeneCards
204929_s_atVAMP5vesicle-associated membrane protein 5 (myobrevin)Source|GeneCards
212895_s_atABRactive BCR-related geneSource|GeneCards
221581_s_atLAT2linker for activation of T cells family, member 2Source|GeneCards
220560_atC11ORF21chromosome 11 open reading frame 21Source|GeneCards
204661_atCD52CD52 antigen (CAMPATH-1 antigen) /// CD52 antigen (CAMPATH-1 antigen)Source|GeneCards
217795_s_atTMEM43transmembrane protein 43Source|GeneCards
210744_s_atIL5RAinterleukin 5 receptor, alphaSource|GeneCards
201700_atCCND3cyclin D3Source|GeneCards
200665_s_atSPARCsecreted protein, acidic, cysteine-rich (osteonectin) /// secreted protein, acidic, cysteine-rich (osteonectin)Source|GeneCards
211744_s_atCD58CD58 antigen, (lymphocyte function-associated antigen 3) /// CD58 antigen, (lymphocyte function-associated antigen 3)Source|GeneCards
221012_s_atTRIM8tripartite motif-containing 8 /// tripartite motif-containing 8Source|GeneCards
212099_atRHOBras homolog gene family, member BSource|GeneCards
207081_s_atPIK4CAphosphatidylinositol 4-kinase, catalytic, alpha polypeptideSource|GeneCards
201473_atJUNBjun B proto-oncogeneSource|GeneCards
204285_s_atPMAIP1phorbol-12-myristate-13-acetate-induced protein 1Source|GeneCards
201497_x_atMYH11myosin, heavy polypeptide 11, smooth muscleSource|GeneCards
211729_x_atBLVRAbiliverdin reductase A /// biliverdin reductase ASource|GeneCards
206622_atTRHthyrotropin-releasing hormoneSource|GeneCards
208893_s_atDUSP6dual specificity phosphatase 6Source|GeneCards
219890_atCLEC5AC-type lectin domain family 5, member ASource|GeneCards
219478_atWFDC1WAP four-disulfide core domain 1Source|GeneCards
217080_s_atHOMER2homer homolog 2 (Drosophila)Source|GeneCards
336_atTBXA2Rthromboxane A2 receptorSource|GeneCards
203932_atHLA-DMBmajor histocompatibility complex, class II, DM beta /// major histocompatibility complex, class II, DM betaSource|GeneCards
219271_atGALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)Source|GeneCards
208892_s_atDUSP6dual specificity phosphatase 6Source|GeneCards
220668_s_atDNMT3BDNA (cytosine-5-)-methyltransferase 3 betaSource|GeneCards
221497_x_atEGLN1egl nine homolog 1 (C. elegans)Source|GeneCards


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