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Gene set: CRASH_AND_BURN_MUT_SHEPARD (C2:MODL:0002)
Standard nameCRASH_AND_BURN_MUT_SHEPARD
Systematic nameC2:MODL:0002
Brief descriptionGenes upregulated in the crash and burn zebra fish mutant
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

208 genes, 208 accessions (Toggle view)

GeneTitleLinks
PTD004hypothetical protein PTD004Source|GeneCards
ATF3activating transcription factor 3Source|GeneCards
SIX2sine oculis homeobox homolog 2 (Drosophila)Source|GeneCards
ATPIF1ATPase inhibitory factor 1Source|GeneCards
ITGB1BP3integrin beta 1 binding protein 3Source|GeneCards
RASL11BRAS-like, family 11, member BSource|GeneCards
SSR1signal sequence receptor, alpha (translocon-associated protein alpha)Source|GeneCards
NOL6nucleolar protein family 6 (RNA-associated)Source|GeneCards
ETF1eukaryotic translation termination factor 1Source|GeneCards
RNU3IP2RNA, U3 small nucleolar interacting protein 2Source|GeneCards
NOL7nucleolar protein 7, 27kDaSource|GeneCards
EGR1early growth response 1Source|GeneCards
LOC388962similar to RIKEN 1810056O20Source|GeneCards
MMP2matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Source|GeneCards
SAS10disrupter of silencing 10Source|GeneCards
LOC131076hypothetical LOC131076Source|GeneCards
SHMT1serine hydroxymethyltransferase 1 (soluble)Source|GeneCards
PIM1pim-1 oncogeneSource|GeneCards
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Source|GeneCards
ZNF593zinc finger protein 593Source|GeneCards
HARSLhistidyl-tRNA synthetase-likeSource|GeneCards
BRF1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)Source|GeneCards
LOC57149hypothetical protein A-211C6.1Source|GeneCards
POP4POP4 (processing of precursor , S. cerevisiae) homologSource|GeneCards
C21ORF33chromosome 21 open reading frame 33Source|GeneCards
EGFL3EGF-like-domain, multiple 3Source|GeneCards
CYR61cysteine-rich, angiogenic inducer, 61Source|GeneCards
SNAI1snail homolog 1 (Drosophila)Source|GeneCards
CCNG1cyclin G1Source|GeneCards
CLDN4claudin 4Source|GeneCards
ABCF2ATP-binding cassette, sub-family F (GCN20), member 2Source|GeneCards
ERBPestrogen receptor binding proteinSource|GeneCards
ANKRD22Ankyrin repeat domain 22Source|GeneCards
BXDC1brix domain containing 1Source|GeneCards
MRPS18Bmitochondrial ribosomal protein S18BSource|GeneCards
MIDNmidnolinSource|GeneCards
LOC83693steroid dehydrogenase-likeSource|GeneCards
WBSCR22Williams Beuren syndrome chromosome region 22Source|GeneCards
MRPS18Amitochondrial ribosomal protein S18ASource|GeneCards
CGI-37comparative gene identification transcript 37Source|GeneCards
VRK2vaccinia related kinase 2Source|GeneCards
TSFMTs translation elongation factor, mitochondrialSource|GeneCards
PTP4A3protein tyrosine phosphatase type IVA, member 3Source|GeneCards
CGI-147CGI-147 proteinSource|GeneCards
GADD45Bgrowth arrest and DNA-damage-inducible, betaSource|GeneCards
CTHcystathionase (cystathionine gamma-lyase)Source|GeneCards
CICcapicua homolog (Drosophila)Source|GeneCards
QARSGlutaminyl-tRNA synthetaseSource|GeneCards
MMP9matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Source|GeneCards
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 3Source|GeneCards
WDR12WD repeat domain 12Source|GeneCards
MRPL12mitochondrial ribosomal protein L12Source|GeneCards
TOB1transducer of ERBB2, 1Source|GeneCards
CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1Source|GeneCards
SLC16A6solute carrier family 16 (monocarboxylic acid transporters), member 6Source|GeneCards
BOP1block of proliferation 1Source|GeneCards
MRPL52mitochondrial ribosomal protein L52Source|GeneCards
MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
DDX49DEAD (Asp-Glu-Ala-Asp) box polypeptide 49Source|GeneCards
KIAA0146KIAA0146 proteinSource|GeneCards
DDX51DEAD (Asp-Glu-Ala-Asp) box polypeptide 51Source|GeneCards
AP3M1adaptor-related protein complex 3, mu 1 subunitSource|GeneCards
C6complement component 6Source|GeneCards
SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3Source|GeneCards
TOMM20translocase of outer mitochondrial membrane 20 homolog (yeast)Source|GeneCards
FLJ10292hypothetical protein FLJ10292Source|GeneCards
STARD10START domain containing 10Source|GeneCards
FLJ11184hypothetical protein FLJ11184Source|GeneCards
BMP2bone morphogenetic protein 2Source|GeneCards
MS4A4Amembrane-spanning 4-domains, subfamily A, member 4Source|GeneCards
EIF4Eeukaryotic translation initiation factor 4ESource|GeneCards
FLJ10534hypothetical protein FLJ10534Source|GeneCards
B3GNT1UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1Source|GeneCards
BAXBCL2-associated X proteinSource|GeneCards
DT1P1A10hypothetical protein DT1P1A10Source|GeneCards
FOXO3Aforkhead box O3ASource|GeneCards
FLJ20718hypothetical protein FLJ20718Source|GeneCards
KRT17keratin 17Source|GeneCards
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDaSource|GeneCards
TXNIPthioredoxin interacting proteinSource|GeneCards
PLK3polo-like kinase 3 (Drosophila)Source|GeneCards
TPRTtrans-prenyltransferaseSource|GeneCards
FOSv-fos FBJ murine osteosarcoma viral oncogene homologSource|GeneCards
AP1M2adaptor-related protein complex 1, mu 2 subunitSource|GeneCards
C10ORF119chromosome 10 open reading frame 119Source|GeneCards
C15ORF12chromosome 15 open reading frame 12Source|GeneCards
C20ORF142chromosome 20 open reading frame 142Source|GeneCards
IGF2insulin-like growth factor 2 (somatomedin A)Source|GeneCards
JDP2jun dimerization protein 2Source|GeneCards
C6ORF11chromosome 6 open reading frame 11Source|GeneCards
IMPDH1IMP (inosine monophosphate) dehydrogenase 1Source|GeneCards
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Source|GeneCards
MARSmethionine-tRNA synthetaseSource|GeneCards
CYP24A1cytochrome P450, family 24, subfamily A, polypeptide 1Source|GeneCards
MYBBP1AMYB binding protein (P160) 1aSource|GeneCards
ZNF330zinc finger protein 330Source|GeneCards
HES1hairy and enhancer of split 1, (Drosophila)Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
LOC255374similar to hypothetical protein MGC49416Source|GeneCards
NOLA1nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)Source|GeneCards
ING5inhibitor of growth family, member 5Source|GeneCards
MKNK2MAP kinase-interacting serine/threonine kinase 2Source|GeneCards
PTGES2prostaglandin E synthase 2Source|GeneCards
C2GNT3core 2 beta-1,6-N-acetylglucosaminyltransferase 3Source|GeneCards
SERPINH1serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)Source|GeneCards
TP53tumor protein p53 (Li-Fraumeni syndrome)Source|GeneCards
DRG2developmentally regulated GTP binding protein 2Source|GeneCards
CCNG2cyclin G2Source|GeneCards
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinSource|GeneCards
PHLDA2pleckstrin homology-like domain, family A, member 2Source|GeneCards
C16ORF7chromosome 16 open reading frame 7Source|GeneCards
JUNBjun B proto-oncogeneSource|GeneCards
CDX4caudal type homeo box transcription factor 4Source|GeneCards
SLC12A7solute carrier family 12 (potassium/chloride transporters), member 7Source|GeneCards
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Source|GeneCards
MYOGmyogenin (myogenic factor 4)Source|GeneCards
HSPCAheat shock 90kDa protein 1, alphaSource|GeneCards
CIRH1Acirrhosis, autosomal recessive 1A (cirhin)Source|GeneCards
FLJ11273hypothetical protein FLJ11273Source|GeneCards
CASP8caspase 8, apoptosis-related cysteine proteaseSource|GeneCards
RERGRAS-like, estrogen-regulated, growth-inhibitorSource|GeneCards
TP53INP1tumor protein p53 inducible nuclear protein 1Source|GeneCards
NOGnogginSource|GeneCards
SGKserum/glucocorticoid regulated kinaseSource|GeneCards
C14ORF21chromosome 14 open reading frame 21Source|GeneCards
RPL10Lribosomal protein L10-likeSource|GeneCards
ARMETarginine-rich, mutated in early stage tumorsSource|GeneCards
WDR8WD repeat domain 8Source|GeneCards
ANGPTL3angiopoietin-like 3Source|GeneCards
HSPA1Lheat shock 70kDa protein 1-likeSource|GeneCards
FTSJ3FtsJ homolog 3 (E. coli)Source|GeneCards
ODC1ornithine decarboxylase 1Source|GeneCards
ELOVL1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1Source|GeneCards
C8ORF4chromosome 8 open reading frame 4Source|GeneCards
FTSJ1FtsJ homolog 1 (E. coli)Source|GeneCards
FN1fibronectin 1Source|GeneCards
BTG2BTG family, member 2Source|GeneCards
ZNF259zinc finger protein 259Source|GeneCards
HSPA9Bheat shock 70kDa protein 9B (mortalin-2)Source|GeneCards
FBLfibrillarinSource|GeneCards
HIST1H3Bhistone 1, H3bSource|GeneCards
PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14ASource|GeneCards
GPD1glycerol-3-phosphate dehydrogenase 1 (soluble)Source|GeneCards
NOC4neighbor of COX4Source|GeneCards
PRSS25protease, serine, 25Source|GeneCards
ITGB4BPintegrin beta 4 binding proteinSource|GeneCards
AK3L1Adenylate kinase 3Source|GeneCards
SATspermidine/spermine N1-acetyltransferaseSource|GeneCards
RRS1RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)Source|GeneCards
CORTcortistatinSource|GeneCards
HOM-TES-103HOM-TES-103 tumor antigen-likeSource|GeneCards
IMP4IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)Source|GeneCards
SEC23BSec23 homolog B (S. cerevisiae)Source|GeneCards
HSPA4heat shock 70kDa protein 4Source|GeneCards
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1Source|GeneCards
PDLIM3PDZ and LIM domain 3Source|GeneCards
C14ORF58chromosome 14 open reading frame 58Source|GeneCards
DUSP5dual specificity phosphatase 5Source|GeneCards
NOL8nucleolar protein 8Source|GeneCards
SLC3A2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2Source|GeneCards
PWP1nuclear phosphoprotein similar to S. cerevisiae PWP1Source|GeneCards
FSTfollistatinSource|GeneCards
JUNv-jun sarcoma virus 17 oncogene homolog (avian)Source|GeneCards
DSCR1Down syndrome critical region gene 1Source|GeneCards
LOC90139tetraspanin similiar to uroplakin 1Source|GeneCards
RNASET2ribonuclease T2Source|GeneCards
TUBA8tubulin, alpha 8Source|GeneCards
ADAM10a disintegrin and metalloproteinase domain 10Source|GeneCards
AKR7A2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)Source|GeneCards
C20ORF155chromosome 20 open reading frame 155Source|GeneCards
CEBPBCCAAT/enhancer binding protein (C/EBP), betaSource|GeneCards
DUSP4dual specificity phosphatase 4Source|GeneCards
MRPS26mitochondrial ribosomal protein S26Source|GeneCards
IBRDC2IBR domain containing 2Source|GeneCards
PES1pescadillo homolog 1, containing BRCT domain (zebrafish)Source|GeneCards
RPS27Lribosomal protein S27-likeSource|GeneCards
MRPL22mitochondrial ribosomal protein L22Source|GeneCards
KLF2Kruppel-like factor 2 (lung)Source|GeneCards
RBP4retinol binding protein 4, plasmaSource|GeneCards
PINX1PIN2-interacting protein 1Source|GeneCards
RGC32RGC32 proteinSource|GeneCards
PAF53Polymerase (RNA) I associated factor 1Source|GeneCards
PPANpeter pan homolog (Drosophila)Source|GeneCards
SRPRBsignal recognition particle receptor, B subunitSource|GeneCards


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