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Gene set: CRASH_AND_BURN_WT_SHEPARD (C2:MODL:0001)
Standard nameCRASH_AND_BURN_WT_SHEPARD
Systematic nameC2:MODL:0001
Brief descriptionGenes upregulated in zebra fish wild type compared to the crash and burn mutant
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
A major goal of cancer research has been to identify genes that
contribute to cancer formation. The similar pathology between
zebrafish and human tumors, as well as the past success of large-scale
genetic screens in uncovering human disease genes, makes zebrafish
an ideal system in which to find such new genes. Here, we show
that a zebrafish forward genetic screen uncovered multiple cell
proliferation mutants including one mutant, crash&burn (crb),
that represents a loss-of-function mutation in bmyb, a transcriptional
regulator and member of a putative proto-oncogene family. crb
mutant embryos have defects in mitotic progression and spindle
formation, and exhibit genome instability. Regulation of cyclin
B levels by bmyb appears to be the mechanism of mitotic accumulation
in crb. Carcinogenesis studies reveal increased cancer susceptibility
in adult crb heterozygotes. Gene-expression signatures associated
with loss of bmyb in zebrafish are also correlated with conserved
signatures in human tumor samples, and down-regulation of the
B-myb signature genes is associated with retention of p53 function.
Our findings show that zebrafish screens can uncover cancer pathways,
and demonstrate that loss of function of bmyb is associated with
cancer. 
Publication URL16150706
External linksna
Keywords & MeSH headingsna
OrganismZebra Fish
Contributed byJennifer Shepard
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

198 genes, 198 accessions (Toggle view)

GeneTitleLinks
AURKBaurora kinase BSource|GeneCards
ZNF184zinc finger protein 184 (Kruppel-like)Source|GeneCards
PRC1protein regulator of cytokinesis 1Source|GeneCards
ARNT2aryl-hydrocarbon receptor nuclear translocator 2Source|GeneCards
ITGB1BP3integrin beta 1 binding protein 3Source|GeneCards
SOX3SRY (sex determining region Y)-box 3Source|GeneCards
PLK4polo-like kinase 4 (Drosophila)Source|GeneCards
TACC3transforming, acidic coiled-coil containing protein 3Source|GeneCards
PUM1pumilio homolog 1 (Drosophila)Source|GeneCards
PGBD4piggyBac transposable element derived 4Source|GeneCards
CDCA3cell division cycle associated 3Source|GeneCards
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
BUB3BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)Source|GeneCards
MYO10myosin XSource|GeneCards
CKAP2cytoskeleton associated protein 2Source|GeneCards
MYCL1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)Source|GeneCards
C5ORF5chromosome 5 open reading frame 5Source|GeneCards
NUMA1nuclear mitotic apparatus protein 1Source|GeneCards
CDC27cell division cycle 27Source|GeneCards
BMS1LBMS1-like, ribosome assembly protein (yeast)Source|GeneCards
CRYBB1crystallin, beta B1Source|GeneCards
FBXO5F-box only protein 5Source|GeneCards
MYH8myosin, heavy polypeptide 8, skeletal muscle, perinatalSource|GeneCards
FLJ12547hypothetical protein FLJ12547Source|GeneCards
DIO2deiodinase, iodothyronine, type IISource|GeneCards
ASCL1achaete-scute complex-like 1 (Drosophila)Source|GeneCards
TNXBtenascin XBSource|GeneCards
CDCA2cell division cycle associated 2Source|GeneCards
PLEKHF1pleckstrin homology domain containing, family F (with FYVE domain) member 1Source|GeneCards
ZNF511zinc finger protein 511Source|GeneCards
ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
KHDRBS1KH domain containing, RNA binding, signal transduction associated 1Source|GeneCards
FLJ22624FLJ22624 proteinSource|GeneCards
PCDH18protocadherin 18Source|GeneCards
NDE1nudE nuclear distribution gene E homolog 1 (A. nidulans)Source|GeneCards
C10ORF3chromosome 10 open reading frame 3Source|GeneCards
CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
MELKmaternal embryonic leucine zipper kinaseSource|GeneCards
GUCA1Aguanylate cyclase activator 1A (retina)Source|GeneCards
MT2Ametallothionein 2ASource|GeneCards
TK1thymidine kinase 1, solubleSource|GeneCards
HMGA1high mobility group AT-hook 1Source|GeneCards
GTSE1G-2 and S-phase expressed 1Source|GeneCards
CKS2CDC28 protein kinase regulatory subunit 2Source|GeneCards
NR2F1nuclear receptor subfamily 2, group F, member 1Source|GeneCards
TMPOthymopoietinSource|GeneCards
FOXB1forkhead box B1Source|GeneCards
POU3F2POU domain, class 3, transcription factor 2Source|GeneCards
HLX1H2.0-like homeo box 1 (Drosophila)Source|GeneCards
HDAC2histone deacetylase 2Source|GeneCards
PTPROprotein tyrosine phosphatase, receptor type, OSource|GeneCards
IRX1iroquois homeobox protein 1Source|GeneCards
RTKNrhotekinSource|GeneCards
POU3F3POU domain, class 3, transcription factor 3Source|GeneCards
HMGN3high mobility group nucleosomal binding domain 3Source|GeneCards
KIAA1458KIAA1458 proteinSource|GeneCards
KRT2Akeratin 2A (epidermal ichthyosis bullosa of Siemens)Source|GeneCards
DDX20DEAD (Asp-Glu-Ala-Asp) box polypeptide 20Source|GeneCards
SOX21SRY (sex determining region Y)-box 21Source|GeneCards
SLC34A1solute carrier family 34 (sodium phosphate), member 1Source|GeneCards
BUB1BBUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)Source|GeneCards
MKI67antigen identified by monoclonal antibody Ki-67Source|GeneCards
ANLNanillin, actin binding protein (scraps homolog, Drosophila)Source|GeneCards
KIAA1731KIAA1731 proteinSource|GeneCards
NEUROG1neurogenin 1Source|GeneCards
LHX1LIM homeobox 1Source|GeneCards
GREB1GREB1 proteinSource|GeneCards
ANP32Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member BSource|GeneCards
DEKDEK oncogene (DNA binding)Source|GeneCards
TPX2TPX2, microtubule-associated protein homolog (Xenopus laevis)Source|GeneCards
NDUFB3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDaSource|GeneCards
CRYBA4crystallin, beta A4Source|GeneCards
ENO3enolase 3, (beta, muscle)Source|GeneCards
ATP1A1ATPase, Na+/K+ transporting, alpha 1 polypeptideSource|GeneCards
INSM1insulinoma-associated 1Source|GeneCards
KIF2Ckinesin family member 2CSource|GeneCards
TTKTTK protein kinaseSource|GeneCards
PLP1proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)Source|GeneCards
UTXubiquitously transcribed tetratricopeptide repeat gene, X chromosomeSource|GeneCards
RACGAP1Rac GTPase activating protein 1Source|GeneCards
HEY1hairy/enhancer-of-split related with YRPW motif 1Source|GeneCards
PAX2paired box gene 2Source|GeneCards
KIF11kinesin family member 11Source|GeneCards
TM7SF2transmembrane 7 superfamily member 2Source|GeneCards
NOTCH2Notch homolog 2 (Drosophila)Source|GeneCards
PPP1R3Cprotein phosphatase 1, regulatory (inhibitor) subunit 3CSource|GeneCards
PON1paraoxonase 1Source|GeneCards
FLJ11029hypothetical protein FLJ11029Source|GeneCards
EDG1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1Source|GeneCards
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)Source|GeneCards
OIP5Opa-interacting protein 5Source|GeneCards
AKAP9A kinase (PRKA) anchor protein (yotiao) 9Source|GeneCards
SFRP1secreted frizzled-related protein 1Source|GeneCards
PRIM2Aprimase, polypeptide 2A, 58kDaSource|GeneCards
SMTNsmoothelinSource|GeneCards
CCNB2cyclin B2Source|GeneCards
FLJ21827hypothetical protein FLJ21827Source|GeneCards
LGMNlegumainSource|GeneCards
EN2engrailed homolog 2Source|GeneCards
KIF23kinesin family member 23Source|GeneCards
TTNtitinSource|GeneCards
NELL2NEL-like 2 (chicken)Source|GeneCards
UCP2uncoupling protein 2 (mitochondrial, proton carrier)Source|GeneCards
TNRC9trinucleotide repeat containing 9Source|GeneCards
ECT2epithelial cell transforming sequence 2 oncogeneSource|GeneCards
NFIL3nuclear factor, interleukin 3 regulatedSource|GeneCards
RLFRearranged L-myc fusionSource|GeneCards
HOXB3homeo box B3Source|GeneCards
ZP2zona pellucida glycoprotein 2 (sperm receptor)Source|GeneCards
ARID5BAT rich interactive domain 5B (MRF1-like)Source|GeneCards
ARHGAP12Rho GTPase activating protein 12Source|GeneCards
FGFR4fibroblast growth factor receptor 4Source|GeneCards
FLJ20641hypothetical protein FLJ20641Source|GeneCards
CHD5chromodomain helicase DNA binding protein 5Source|GeneCards
MGC17943hypothetical protein MGC17943Source|GeneCards
SOX11SRY (sex determining region Y)-box 11Source|GeneCards
CTSLcathepsin LSource|GeneCards
LOC55924hypothetical protein LOC55924Source|GeneCards
NOVA2neuro-oncological ventral antigen 2Source|GeneCards
HES6hairy and enhancer of split 6 (Drosophila)Source|GeneCards
MASTLmicrotubule associated serine/threonine kinase-likeSource|GeneCards
CCNB3cyclin B3Source|GeneCards
SHCBP1likely ortholog of mouse Shc SH2-domain binding protein 1Source|GeneCards
GDF10growth differentiation factor 10Source|GeneCards
CCNB1cyclin B1Source|GeneCards
ADARB2adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)Source|GeneCards
PROSAPIP1ProSAPiP1 proteinSource|GeneCards
MDKmidkine (neurite growth-promoting factor 2)Source|GeneCards
FUBP1far upstream element (FUSE) binding protein 1Source|GeneCards
ASPMasp (abnormal spindle)-like, microcephaly associated (Drosophila)Source|GeneCards
MGC49942hypothetical protein MGC49942Source|GeneCards
FOXM1forkhead box M1Source|GeneCards
NEUROD4neurogenic differentiation 4Source|GeneCards
MBD2methyl-CpG binding domain protein 2Source|GeneCards
POU3F1POU domain, class 3, transcription factor 1Source|GeneCards
SLIT3slit homolog 3 (Drosophila)Source|GeneCards
EBFearly B-cell factorSource|GeneCards
PCDHGC3protocadherin gamma subfamily C, 3Source|GeneCards
TRIM39tripartite motif-containing 39Source|GeneCards
DLG7discs, large homolog 7 (Drosophila)Source|GeneCards
SILTAL1 (SCL) interrupting locusSource|GeneCards
RASGEF1ARasGEF domain family, member 1ASource|GeneCards
FZD10frizzled homolog 10 (Drosophila)Source|GeneCards
JAG1jagged 1 (Alagille syndrome)Source|GeneCards
FZD9frizzled homolog 9 (Drosophila)Source|GeneCards
CEP2centrosomal protein 2Source|GeneCards
AP4M1adaptor-related protein complex 4, mu 1 subunitSource|GeneCards
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting proteinSource|GeneCards
DPYSL3dihydropyrimidinase-like 3Source|GeneCards
ZIC2Zic family member 2 (odd-paired homolog, Drosophila)Source|GeneCards
KIF14kinesin family member 14Source|GeneCards
GFAPglial fibrillary acidic proteinSource|GeneCards
G3BP2Ras-GTPase activating protein SH3 domain-binding protein 2Source|GeneCards
LMNB2lamin B2Source|GeneCards
GRIK3glutamate receptor, ionotropic, kainate 3Source|GeneCards
RHORhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)Source|GeneCards
OTPorthopedia homolog (Drosophila)Source|GeneCards
FZD5frizzled homolog 5 (Drosophila)Source|GeneCards
PHF3PHD finger protein 3Source|GeneCards
TUBA8tubulin, alpha 8Source|GeneCards
GPSM1G-protein signalling modulator 1 (AGS3-like, C. elegans)Source|GeneCards
BIRC5baculoviral IAP repeat-containing 5 (survivin)Source|GeneCards
SIAT8Bsialyltransferase 8B (alpha-2, 8-sialyltransferase)Source|GeneCards
C15ORF20chromosome 15 open reading frame 20Source|GeneCards
GAS1growth arrest-specific 1Source|GeneCards
CDC20CDC20 cell division cycle 20 homolog (S. cerevisiae)Source|GeneCards
ZNF585Azinc finger protein 585ASource|GeneCards
OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
OLIG2oligodendrocyte lineage transcription factor 2Source|GeneCards
SKIV-ski sarcoma viral oncogene homolog (avian)Source|GeneCards
PTPRNprotein tyrosine phosphatase, receptor type, NSource|GeneCards
GOLGB1golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1Source|GeneCards
PTENphosphatase and tensin homolog (mutated in multiple advanced cancers 1)Source|GeneCards


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