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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: EPITHELIAL_UP_ZUCCHI (C2:PERT:0114)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>EPITHELIAL_UP_ZUCCHI</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0114</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>The 50 most upregulated genes in primary invasive breast dutcal carcinoma or metastatic breast carcinoma isolated from lymph nodes, as compared to normal mammary epithelium.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Expression profiles of breast carcinomas are difficult to interpret
when they are obtained from tissue in toto, which may contain
a large proportion of non-cancer cells. To avoid this problem,
we microscopically isolated cells from a primary invasive ductal
carcinoma of the breast and from an axillary node harboring a
metastatic breast carcinoma, to obtain pure populations of carcinoma
cells (approximately 500) and used them for serial analysis of
gene expression. The expression profiles generated from both populations
of cells were compared with the profile of a disease-free mammary
epithelium. We showed that the expression profiles obtained are
exclusive of carcinoma cells with no contribution of non-epithelial
cells. From a total of 16,939 unique tags analyzed, we detected
559 statistically significant changes in gene expression; some
of these genes have not been previously associated with breast
cancer. We observed that many of the down-regulated genes are
the same in both cancers, whereas the up-regulated genes are completely
different, suggesting that the down-regulation of a set of genes
may be the basic mechanism of cancer formation, while the up-regulation
may characterize and possibly control the state of evolution of
individual cancers. The results obtained may help in characterizing
the neoplastic process of breast cancer. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15608061' target='EXTERNAL'>15608061</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Neoplastic,In Situ Hybridization,Epithelial Cells,Breast Neoplasms,Complementary/metabolism,DNA,Lymphatic Metastasis,Down-Regulation,Humans,Carcinoma,Epithelium/metabolism,pathology,genetics,Up-Regulation,Gene Expression Regulation,Gene Library,metabolism</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='EPITHELIAL_UP_ZUCCHI.grp'>grp</a>|<a href='EPITHELIAL_UP_ZUCCHI.xml'>xml</a>|<a href='EPITHELIAL_UP_ZUCCHI.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>50 genes, 50 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>YWHAZ</td><td>tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=YWHAZ' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?YWHAZ' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HMGA1</td><td>high mobility group AT-hook 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HMGA1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HMGA1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ANKRD10</td><td>ankyrin repeat domain 10</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ANKRD10' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ANKRD10' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>RPN2</td><td>ribophorin II</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RPN2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RPN2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NME1</td><td>non-metastatic cells 1, protein (NM23A) expressed in</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NME1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NME1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GNB2L1</td><td>guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GNB2L1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GNB2L1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FN1</td><td>fibronectin 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ENO1</td><td>enolase 1, (alpha)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ENO1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ENO1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DUSP23</td><td>dual specificity phosphatase 23</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DUSP23' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DUSP23' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TRAP1</td><td>TNF receptor-associated protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TRAP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TRAP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>FSCN1</td><td>fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FSCN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FSCN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CCT5</td><td>chaperonin containing TCP1, subunit 5 (epsilon)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCT5' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCT5' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DHX9</td><td>DEAH (Asp-Glu-Ala-His) box polypeptide 9</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DHX9' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DHX9' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>EDN2</td><td>endothelin 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EDN2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EDN2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>LDHA</td><td>lactate dehydrogenase A</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LDHA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LDHA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CTGF</td><td>connective tissue growth factor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CTGF' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CTGF' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PTMA</td><td>prothymosin, alpha (gene sequence 28)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PTMA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PTMA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>NNMT</td><td>nicotinamide N-methyltransferase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NNMT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NNMT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>STEAP</td><td>six transmembrane epithelial antigen of the prostate</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=STEAP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?STEAP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GAGED2</td><td>G antigen, family D, 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GAGED2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GAGED2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SFRS6</td><td>splicing factor, arginine/serine-rich 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SFRS6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SFRS6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HMGB1</td><td>high-mobility group box 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HMGB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HMGB1' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>ZNF9</td><td>zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ZNF9' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ZNF9' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SRCAP</td><td>Snf2-related CBP activator protein</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SRCAP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SRCAP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SNCAIP</td><td>synuclein, alpha interacting protein (synphilin)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SNCAIP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SNCAIP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HIF1A</td><td>hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HIF1A' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HIF1A' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DGKQ</td><td>diacylglycerol kinase, theta 110kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DGKQ' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DGKQ' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr></tr><tr><td>HSPA8</td><td>heat shock 70kDa protein 8</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HSPA8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HSPA8' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IGFBP4</td><td>insulin-like growth factor binding protein 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IGFBP4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IGFBP4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>UBA52</td><td>ubiquitin A-52 residue ribosomal protein fusion product 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=UBA52' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?UBA52' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>YKT6</td><td>SNARE protein Ykt6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=YKT6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?YKT6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TPT1</td><td>tumor protein, translationally-controlled 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TPT1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TPT1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PTPN1</td><td>protein tyrosine phosphatase, non-receptor type 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PTPN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PTPN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GNG11</td><td>guanine nucleotide binding protein (G protein), gamma 11</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GNG11' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GNG11' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>AHCY</td><td>S-adenosylhomocysteine hydrolase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AHCY' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AHCY' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PPIA</td><td>peptidylprolyl isomerase A (cyclophilin A)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PPIA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PPIA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>IFITM3</td><td>interferon induced transmembrane protein 3 (1-8U)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IFITM3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IFITM3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>H2AFZ</td><td>H2A histone family, member Z</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=H2AFZ' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?H2AFZ' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>HNRPC</td><td>heterogeneous nuclear ribonucleoprotein C (C1/C2)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HNRPC' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HNRPC' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CCNA2</td><td>cyclin A2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCNA2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCNA2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CAP1</td><td>CAP, adenylate cyclase-associated protein 1 (yeast)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CAP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CAP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>ADNP</td><td>activity-dependent neuroprotector</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ADNP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ADNP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SAE1</td><td>SUMO-1 activating enzyme subunit 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SAE1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SAE1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>TGFA</td><td>transforming growth factor, alpha</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TGFA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TGFA' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>CYFIP1</td><td>cytoplasmic FMR1 interacting protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CYFIP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CYFIP1' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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