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Gene set: FAB_M7_ROSS (C2:PERT:0050)
Standard nameFAB_M7_ROSS
Systematic nameC2:PERT:0050
Brief descriptionGenes that distinguish pediatric acute myeloid leukemia (AML) subtype FAB-M7.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Contemporary treatment of pediatric acute myeloid leukemia (AML)
requires the assignment of patients to specific risk groups. To
explore whether expression profiling of leukemic blasts could
accurately distinguish between the known risk groups of AML, we
analyzed 130 pediatric and 20 adult AML diagnostic bone marrow
or peripheral blood samples using the Affymetrix U133A microarray.
Class discriminating genes were identified for each of the major
prognostic subtypes of pediatric AML, including t(15;17)[PML-RARalpha],
t(8;21)[AML1-ETO], inv(16) [CBFbeta-MYH11], MLL chimeric fusion
genes, and cases classified as FAB-M7. When subsets of these genes
were used in supervised learning algorithms, an overall classification
accuracy of more than 93% was achieved. Moreover, we were able
to use the expression signatures generated from the pediatric
samples to accurately classify adult de novo AMLs with the same
genetic lesions. The class discriminating genes also provided
novel insights into the molecular pathobiology of these leukemias.
Finally, using a combined pediatric data set of 130 AMLs and 137
acute lymphoblastic leukemias, we identified an expression signature
for cases with MLL chimeric fusion genes irrespective of lineage.
Surprisingly, AMLs containing partial tandem duplications of MLL
failed to cluster with MLL chimeric fusion gene cases, suggesting
a significant difference in their underlying mechanism of transformation.
Publication URL15226186
External linksna
Keywords & MeSH headingsTranscription Factors/genetics,Prognosis,Acute,Gene Expression Profiling,P.H.S.,classification,Oncogene Proteins,Proto-Oncogenes/genetics,Risk Factors,Blood,Fusion/genetics,Humans,Leukemia,genetics,Myelocytic,Child,DNA-Binding Proteins/genetics,Cluster Analysis,Algorithms,Tandem Repeat Sequences,Bone Marrow
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

69 genes, 100 accessions (Toggle view)

AccessionGeneTitleLinks
210446_atGATA1GATA binding protein 1 (globin transcription factor 1)Source|GeneCards
206655_s_atGP1BBglycoprotein Ib (platelet), beta polypeptideSource|GeneCards
214039_s_atLAPTM4Blysosomal associated protein transmembrane 4 betaSource|GeneCards
216054_x_atMYL4myosin, light polypeptide 4, alkali; atrial, embryonicSource|GeneCards
220994_s_atSTXBP6syntaxin binding protein 6 (amisyn)Source|GeneCards
216804_s_atPDLIM5PDZ and LIM domain 5Source|GeneCards
200642_atSOD1superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))Source|GeneCards
209218_atSQLEsqualene epoxidaseSource|GeneCards
210532_s_atC14ORF2chromosome 14 open reading frame 2Source|GeneCards
202983_atSMARCA3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3Source|GeneCards
213088_s_atDNAJC9DnaJ (Hsp40) homolog, subfamily C, member 9Source|GeneCards
205127_atPTGS1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)Source|GeneCards
209710_atGATA2GATA binding protein 2Source|GeneCards
205262_atKCNH2potassium voltage-gated channel, subfamily H (eag-related), member 2Source|GeneCards
203486_s_atARMC8armadillo repeat containing 8Source|GeneCards
210907_s_atPDCD10programmed cell death 10Source|GeneCards
212412_atPDLIM5PDZ and LIM domain 5Source|GeneCards
59644_atBMP2KBMP2 inducible kinaseSource|GeneCards
201147_s_atTIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
202218_s_atFADS2fatty acid desaturase 2Source|GeneCards
206283_s_atTAL1T-cell acute lymphocytic leukemia 1Source|GeneCards
208352_x_atANK1ankyrin 1, erythrocyticSource|GeneCards
218111_s_atCMAScytidine monophosphate N-acetylneuraminic acid synthetaseSource|GeneCards
201149_s_atTIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
213553_x_atAPOC1apolipoprotein C-ISource|GeneCards
203258_atDRAP1DR1-associated protein 1 (negative cofactor 2 alpha)Source|GeneCards
221704_s_atFLJ12750hypothetical protein FLJ12750 /// hypothetical protein FLJ12750Source|GeneCards
211254_x_atRHAGRhesus blood group-associated glycoproteinSource|GeneCards
209586_s_atPRUNEprune homolog (Drosophila)Source|GeneCards
207808_s_atPROS1protein S (alpha)Source|GeneCards
206793_atPNMTphenylethanolamine N-methyltransferaseSource|GeneCards
202949_s_atFHL2four and a half LIM domains 2Source|GeneCards
219215_s_atSLC39A4solute carrier family 39 (zinc transporter), member 4Source|GeneCards
212224_atALDH1A1aldehyde dehydrogenase 1 family, member A1Source|GeneCards
201148_s_atTIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
206494_s_atITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)Source|GeneCards
203243_s_atPDLIM5PDZ and LIM domain 5Source|GeneCards
204904_atGJA4gap junction protein, alpha 4, 37kDa (connexin 37)Source|GeneCards
207389_atGP1BAglycoprotein Ib (platelet), alpha polypeptideSource|GeneCards
215813_s_atPTGS1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)Source|GeneCards
206306_atRYR3ryanodine receptor 3Source|GeneCards
208653_s_atCD164CD164 antigen, sialomucinSource|GeneCards
210504_atKLF1Kruppel-like factor 1 (erythroid)Source|GeneCards
203382_s_atAPOEapolipoprotein ESource|GeneCards
212397_atRDXradixinSource|GeneCards
210395_x_atMYL4myosin, light polypeptide 4, alkali; atrial, embryonicSource|GeneCards
206702_atTEKTEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)Source|GeneCards
219546_atBMP2KBMP2 inducible kinaseSource|GeneCards
201150_s_atTIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
221896_s_atHIG1likely ortholog of mouse hypoxia induced gene 1Source|GeneCards
216925_s_atTAL1T-cell acute lymphocytic leukemia 1Source|GeneCards
210986_s_atTPM1tropomyosin 1 (alpha)Source|GeneCards
207194_s_atICAM4intercellular adhesion molecule 4, Landsteiner-Wiener blood groupSource|GeneCards
205390_s_atANK1ankyrin 1, erythrocytic /// ankyrin 1, erythrocyticSource|GeneCards
204321_atNEO1neogenin homolog 1 (chicken)Source|GeneCards
204416_x_atAPOC1apolipoprotein C-ISource|GeneCards
208029_s_atLAPTM4Blysosomal associated protein transmembrane 4 beta /// lysosomal associated protein transmembrane 4 betaSource|GeneCards
7212372_at
206077_atKELKell blood groupSource|GeneCards
217845_x_atHIG1likely ortholog of mouse hypoxia induced gene 1Source|GeneCards
205352_atSERPINI1serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1Source|GeneCards
210088_x_atMYL4myosin, light polypeptide 4, alkali; atrial, embryonicSource|GeneCards
208767_s_atLAPTM4Blysosomal associated protein transmembrane 4 betaSource|GeneCards
203196_atABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4Source|GeneCards
40687_atGJA4gap junction protein, alpha 4, 37kDa (connexin 37)Source|GeneCards
211828_s_atTNIKTRAF2 and NCK interacting kinaseSource|GeneCards
209049_s_atPRKCBP1protein kinase C binding protein 1Source|GeneCards
209881_s_atLATlinker for activation of T cellsSource|GeneCards
211005_atLATlinker for activation of T cellsSource|GeneCards
221021_s_atCTNNBL1catenin, beta like 1 /// catenin, beta like 1Source|GeneCards
208353_x_atANK1ankyrin 1, erythrocyticSource|GeneCards
206146_s_atRHAGRhesus blood group-associated glycoproteinSource|GeneCards
204720_s_atDNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6Source|GeneCards
210215_atTFR2transferrin receptor 2Source|GeneCards
213107_atTNIKTRAF2 and NCK interacting kinaseSource|GeneCards
218711_s_atSDPRserum deprivation response (phosphatidylserine binding protein)Source|GeneCards
210987_x_atTPM1tropomyosin 1 (alpha)Source|GeneCards
206145_atRHAGRhesus blood group-associated glycoproteinSource|GeneCards
208971_atURODuroporphyrinogen decarboxylaseSource|GeneCards
203242_s_atPDLIM5PDZ and LIM domain 5Source|GeneCards
204331_s_atMRPS12mitochondrial ribosomal protein S12Source|GeneCards
209839_atDNM3dynamin 3Source|GeneCards
217963_s_atNGFRAP1nerve growth factor receptor (TNFRSF16) associated protein 1Source|GeneCards
210036_s_atKCNH2potassium voltage-gated channel, subfamily H (eag-related), member 2Source|GeneCards
208970_s_atURODuroporphyrinogen decarboxylaseSource|GeneCards
219737_s_atPCDH9protocadherin 9Source|GeneCards
210621_s_atRASA1RAS p21 protein activator (GTPase activating protein) 1Source|GeneCards
205389_s_atANK1ankyrin 1, erythrocytic /// ankyrin 1, erythrocyticSource|GeneCards
202753_atPSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 6Source|GeneCards
210762_s_atDLC1deleted in liver cancer 1Source|GeneCards
221488_s_atC6ORF82chromosome 6 open reading frame 82Source|GeneCards
205128_x_atPTGS1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)Source|GeneCards
203613_s_atNDUFB6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDaSource|GeneCards
212694_s_atPCCBpropionyl Coenzyme A carboxylase, beta polypeptideSource|GeneCards
202620_s_atPLOD2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2Source|GeneCards
206493_atITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)Source|GeneCards
201830_s_atNET1neuroepithelial cell transforming gene 1Source|GeneCards
202279_atC14ORF2chromosome 14 open reading frame 2Source|GeneCards
209585_s_atMINPP1multiple inositol polyphosphate histidine phosphatase, 1Source|GeneCards
216956_s_atITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)Source|GeneCards


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