[an error occurred while processing this directive]
Gene set: HISTONE_UP_PEART (C2:PERT:0110)
Standard nameHISTONE_UP_PEART
Systematic nameC2:PERT:0110
Brief descriptionCell-proliferation-related genes upregulated by SAHA and depsipeptide (histone deacetylase inhibitors)
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract

Toggle abstract view

Histone deacetylase inhibitors (HDACis) inhibit tumor cell growth
and survival, possibly through their ability to regulate the expression
of specific proliferative and/or apoptotic genes. However, the
HDACi-regulated genes necessary and/or sufficient for their biological
effects remain undefined. We demonstrate that the HDACis suberoylanilide
hydroxamic acid (SAHA) and depsipeptide regulate a highly overlapping
gene set with at least 22% of genes showing altered expression
over a 16-h culture period. SAHA and depsipeptide coordinately
regulated the expression of several genes within distinct apoptosis
and cell cycle pathways. Multiple genes within the Myc, type beta
TGF, cyclin/cyclin-dependent kinase, TNF, Bcl-2, and caspase pathways
were regulated in a manner that favored induction of apoptosis
and decreased cellular proliferation. APAF-1, a gene central to
the intrinsic apoptotic pathway, was induced by SAHA and depsipeptide
and shown to be important, but not essential, for HDACi-induced
cell death. Overexpression of p16(INK4A) and arrest of cells in
G(1) can suppress HDACi-mediated apoptosis. Although p16(INK4A)
did not affect the genome-wide transcription changes mediated
by SAHA, a small number of apoptotic genes, including BCLXL and
B-MYB, were differentially regulated in a manner consistent with
attenuated HDACi-mediated apoptosis in arrested cells. We demonstrate
that different HDACi alter transcription of a large and common
set of genes that control diverse molecular pathways important
for cell survival and proliferation. The ability of HDACi to target
multiple apoptotic and cell proliferation pathways may provide
a competitive advantage over other chemotherapeutic agents because
suppression/loss of a single pathway may not confer resistance
to these agents.
Publication URL15738394
External linksna
Keywords & MeSH headingsna
OrganismHuman
Contributed byKate Stafford
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

59 genes, 59 accessions (Toggle view)

GeneTitleLinks
BLMBloom syndromeSource|GeneCards
QSCN6quiescin Q6Source|GeneCards
CKS2CDC28 protein kinase regulatory subunit 2Source|GeneCards
TREX1three prime repair exonuclease 1Source|GeneCards
GPR21G protein-coupled receptor 21Source|GeneCards
BTG2BTG family, member 2Source|GeneCards
GRLF1glucocorticoid receptor DNA binding factor 1Source|GeneCards
STAMBPSTAM binding proteinSource|GeneCards
PRDX1peroxiredoxin 1Source|GeneCards
TOB1transducer of ERBB2, 1Source|GeneCards
BLZF1basic leucine zipper nuclear factor 1 (JEM-1)Source|GeneCards
TUSC2tumor suppressor candidate 2Source|GeneCards
TPD52L2tumor protein D52-like 2Source|GeneCards
CDKN3cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)Source|GeneCards
MXI1MAX interacting protein 1Source|GeneCards
CDC6CDC6 cell division cycle 6 homolog (S. cerevisiae)Source|GeneCards
RAP1ARAP1A, member of RAS oncogene familySource|GeneCards
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix proteinSource|GeneCards
CDK2cyclin-dependent kinase 2Source|GeneCards
APRINandrogen-induced proliferation inhibitorSource|GeneCards
SLC12A6solute carrier family 12 (potassium/chloride transporters), member 6Source|GeneCards
CCNE1cyclin E1Source|GeneCards
HDAC5histone deacetylase 5Source|GeneCards
CCNG2cyclin G2Source|GeneCards
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)Source|GeneCards
ANLNanillin, actin binding protein (scraps homolog, Drosophila)Source|GeneCards
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinSource|GeneCards
TCFL4transcription factor-like 4Source|GeneCards
SIRT2sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)Source|GeneCards
ORC4Lorigin recognition complex, subunit 4-like (yeast)Source|GeneCards
CETN2centrin, EF-hand protein, 2Source|GeneCards
CGRRF1cell growth regulator with ring finger domain 1Source|GeneCards
RECKreversion-inducing-cysteine-rich protein with kazal motifsSource|GeneCards
NDNnecdin homolog (mouse)Source|GeneCards
CCNG1cyclin G1Source|GeneCards
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isoformSource|GeneCards
APBB2amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)Source|GeneCards
MTVR1Mouse Mammary Turmor Virus Receptor homolog 1Source|GeneCards
DCTN1dynactin 1 (p150, glued homolog, Drosophila)Source|GeneCards
CDC37CDC37 cell division cycle 37 homolog (S. cerevisiae)Source|GeneCards
CDC25Ccell division cycle 25CSource|GeneCards
TNFSF9tumor necrosis factor (ligand) superfamily, member 9Source|GeneCards
DCTN3dynactin 3 (p22)Source|GeneCards
KIF2Ckinesin family member 2CSource|GeneCards
DUSP1dual specificity phosphatase 1Source|GeneCards
INSIG1insulin induced gene 1Source|GeneCards
HDAC3histone deacetylase 3Source|GeneCards
BTG1B-cell translocation gene 1, anti-proliferativeSource|GeneCards
NEK2NIMA (never in mitosis gene a)-related kinase 2Source|GeneCards
MAPRE2microtubule-associated protein, RP/EB family, member 2Source|GeneCards
CCNFcyclin FSource|GeneCards
STIM1stromal interaction molecule 1Source|GeneCards
ING1inhibitor of growth family, member 1Source|GeneCards
SESN1sestrin 1Source|GeneCards
CDC34cell division cycle 34Source|GeneCards

[an error occurred while processing this directive]