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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: IL6_STROMA_UP_CROONQUIST (C2:PERT:0067)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>IL6_STROMA_UP_CROONQUIST</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0067</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes upregulated in multiple myeloma cells exposed to the pro-proliferative cytokine IL-6 versus those co-cultured with bone marrow stromal cells.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><p><a onClick="switchAbstract('myvar_a');" title='Toggle abstract view'>Toggle abstract view</a><div id='myvar_a'><pre>ANBL-6, a myeloma cell line, proliferates in response to interleukin
6 (IL-6) stimulation, coculture with bone marrow stromal cells,
and when harboring a constitutively active mutant N-ras gene.
Eighteen samples, including 4 IL-6-treated, 3 mutant N-ras-transfected,
3 normal stroma-stimulated, 2 multiple myeloma (MM) stroma-stimulated,
and 6 untreated controls were profiled using microarrays interrogating
12 626 genes. Global hierarchical clustering analysis distinguished
at least 6 unique expression signatures. Notably, the different
stimuli altered distinct functional gene programs. Class comparison
analysis (P =.001) revealed 138 genes (54% involved in cell cycle)
that distinguished IL-6-stimulated versus nontreated samples.
Eighty-seven genes distinguished stroma-stimulated versus IL-6-treated
samples (22% encoded for extracellular matrix [ECM] proteins).
A total of 130 genes distinguished N-ras transfectants versus
IL-6-treated samples (26% involved in metabolism). A total of
157 genes, 20% of these involved in signaling, distinguished N-ras
from stroma-interacting samples. All 3 stimuli shared 347 genes,
mostly of metabolic function. Genes that distinguished MM1 from
MM4 clinical groups were induced at least by one treatment. Notably,
only 3 genes (ETV5, DUSP6, and KIAA0735) are uniquely induced
in mutant ras-containing cells. We have demonstrated gene expression
patterns in myeloma cells that distinguish an intrinsic genetic
transformation event and patterns derived from both soluble factors
and cell contacts in the bone marrow microenvironment. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12791645' target='EXTERNAL'>12791645</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Cell Communication/physiology,Coculture Techniques,Neoplastic/drug effects/physiology,Non-P.H.S.,Gene Expression Profiling,P.H.S.,Comparative Study,pharmacology,Phenotype,Multiple Myeloma,Humans,Tumor Cells,ras Proteins/metabolism,Stromal Cells,ras,Genes,genetics,Gene Expression Regulation,cytology,physiology,Cell Division/drug effects,Interleukin-6,Mitogen-Activated Protein Kinases/metabolism,Cultured/cytology</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Seq_Accession</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='IL6_STROMA_UP_CROONQUIST.grp'>grp</a>|<a href='IL6_STROMA_UP_CROONQUIST.xml'>xml</a>|<a href='IL6_STROMA_UP_CROONQUIST.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>38 genes, 45 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='4' class='fancy' border='0'><tr><th align='center'>Accession</th><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td width='75%'>X68277</td><td>DUSP1</td><td>dual specificity phosphatase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DUSP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DUSP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>J03040</td><td>SPARC</td><td>secreted protein, acidic, cysteine-rich (osteonectin)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SPARC' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SPARC' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M58459</td><td>RPS4Y1</td><td>ribosomal protein S4, Y-linked 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RPS4Y1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RPS4Y1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M69043</td><td>NFKBIA</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AF056085</td><td>GPR51</td><td>G protein-coupled receptor 51</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GPR51' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GPR51' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>V01512</td><td>FOS</td><td>v-fos FBJ murine osteosarcoma viral oncogene homolog</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FOS' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FOS' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M55153</td><td>TGM2</td><td>transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TGM2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TGM2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>J04130</td><td>CCL4</td><td>chemokine (C-C motif) ligand 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCL4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCL4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>S78569</td><td>LAMA4</td><td>laminin, alpha 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LAMA4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LAMA4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X15880</td><td>COL6A1</td><td>collagen, type VI, alpha 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=COL6A1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?COL6A1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X04430</td><td>IL6</td><td>interleukin 6 (interferon, beta 2)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AL096713</td><td>FER1L3</td><td>fer-1-like 3, myoferlin (C. elegans)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FER1L3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FER1L3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>L19182</td><td>IGFBP7</td><td>insulin-like growth factor binding protein 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IGFBP7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IGFBP7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>J03464</td><td>COL1A2</td><td>collagen, type I, alpha 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=COL1A2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?COL1A2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U24389</td><td>LOXL1</td><td>lysyl oxidase-like 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LOXL1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LOXL1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X13839</td><td>ACTA2</td><td>actin, alpha 2, smooth muscle, aorta</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ACTA2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ACTA2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X15998</td><td>CSPG2</td><td>chondroitin sulfate proteoglycan 2 (versican)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CSPG2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CSPG2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X78947</td><td>CTGF</td><td>connective tissue growth factor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CTGF' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CTGF' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U08021</td><td>NNMT</td><td>nicotinamide N-methyltransferase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NNMT' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NNMT' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M35878</td><td>IGFBP3</td><td>insulin-like growth factor binding protein 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IGFBP3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IGFBP3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>D90144</td></tr><tr><td width='75%'>M77349</td><td>TGFBI</td><td>transforming growth factor, beta-induced, 68kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TGFBI' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TGFBI' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AI246894</td></tr><tr><td width='75%'>S59049</td><td>RGS1</td><td>regulator of G-protein signalling 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RGS1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RGS1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U97669</td><td>NOTCH3</td><td>Notch homolog 3 (Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NOTCH3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NOTCH3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M17733</td><td>TMSB4X</td><td>thymosin, beta 4, X-linked</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TMSB4X' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TMSB4X' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>V00503</td><td>COL1A2</td><td>collagen, type I, alpha 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=COL1A2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?COL1A2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X52022</td><td>COL6A3</td><td>collagen, type VI, alpha 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=COL6A3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?COL6A3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U03057</td><td>FSCN1</td><td>fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FSCN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FSCN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M27830</td></tr><tr><td width='75%'>L49169</td><td>FOSB</td><td>FBJ murine osteosarcoma viral oncogene homolog B</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=FOSB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?FOSB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M12125</td><td>TPM2</td><td>tropomyosin 2 (beta)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TPM2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TPM2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AF052119</td></tr><tr><td width='75%'>K00650</td></tr><tr><td width='75%'>S81914</td><td>IER3</td><td>immediate early response 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IER3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IER3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AB018293</td><td>MICAL2</td><td>flavoprotein oxidoreductase MICAL2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MICAL2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MICAL2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>L13463</td><td>RGS2</td><td>regulator of G-protein signalling 2, 24kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RGS2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RGS2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>L12350</td><td>THBS2</td><td>thrombospondin 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=THBS2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?THBS2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M19267</td><td>TPM1</td><td>tropomyosin 1 (alpha)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TPM1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TPM1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AB029000</td><td>SULF1</td><td>sulfatase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SULF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SULF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>L16895</td><td>LOX</td><td>lysyl oxidase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LOX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LOX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>D32039</td><td>CSPG2</td><td>chondroitin sulfate proteoglycan 2 (versican)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CSPG2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CSPG2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M14083</td><td>SERPINE1</td><td>serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SERPINE1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SERPINE1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M36820</td><td>CXCL2</td><td>chemokine (C-X-C motif) ligand 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CXCL2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CXCL2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>S77154</td><td>NR4A2</td><td>nuclear receptor subfamily 4, group A, member 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NR4A2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NR4A2' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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