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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: IRF3_JURKAT_UP (C2:PERT:0136)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>IRF3_JURKAT_UP</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0136</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes up-regulated by IRF3 in Jurkat (T-cell)</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>Ubiquitously expressed interferon regulatory factor 3 (IRF-3)
is directly activated after virus infection and functions as a
key activator of the immediate-early alpha/beta interferon (IFN)
genes, as well as the RANTES chemokine gene. In the present study,
a tetracycline-inducible expression system expressing a constitutively
active form of IRF-3 (IRF-3 5D) was combined with DNA microarray
analysis to identify target genes regulated by IRF-3. Changes
in mRNA expression profiles of 8,556 genes were monitored after
Tet-inducible expression of IRF-3 5D. Among the genes upregulated
by IRF-3 were transcripts for several known IFN-stimulated genes
(ISGs). Subsequent analysis revealed that IRF-3 directly induced
the expression of ISG56 in an IFN-independent manner through the
IFN-stimulated responsive elements (ISREs) of the ISG56 promoter.
These results demonstrate that, in addition to its role in the
formation of a functional immediate-early IFN-beta enhanceosome,
IRF-3 is able to discriminate among ISRE-containing genes involved
in the establishment of the antiviral state as a direct response
to virus infection. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11991981' target='EXTERNAL'>11991981</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Gene Expression Profiling,Oligonucleotide Array Sequence Analysis,Transcription,Luciferases/genetics,Tetracycline/pharmacology,Humans,Gene Expression,Trans-Activation (Genetics),Promoter Regions (Genetics),genetics,Genetic,Transcription Factors,metabolism,Jurkat Cells</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Yujin Hoshida</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='IRF3_JURKAT_UP.grp'>grp</a>|<a href='IRF3_JURKAT_UP.xml'>xml</a>|<a href='IRF3_JURKAT_UP.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>12 genes, 14 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr><tr></tr></table></div></td></tr></table></div><br><hr>
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