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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: JISON_STRESS (C2:PERT:0041)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>JISON_STRESS</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0041</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes differentially expressed in blood mononuclear cells of clinically stable sickle-cell patients.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><p><a onClick="switchAbstract('myvar_a');" title='Toggle abstract view'>Toggle abstract view</a><div id='myvar_a'><pre>In sickle cell disease, deoxygenation of intra-erythrocytic hemoglobin
S leads to hemoglobin polymerization, erythrocyte rigidity, hemolysis,
and microvascular occlusion. Ischemia-reperfusion injury, plasma
hemoglobin-mediated nitric oxide consumption, and free radical
generation activate systemic inflammatory responses. To characterize
the role of circulating leukocytes in sickle cell pathogenesis
we performed global transcriptional analysis of blood mononuclear
cells from 27 patients in steady-state sickle cell disease (10
patients treated and 17 patients untreated with hydroxyurea) compared
with 13 control subjects. We used gender-specific gene expression
to validate human microarray experiments. Patients with sickle
cell disease demonstrated differential gene expression of 112
genes involved in heme metabolism, cell-cycle regulation, antioxidant
and stress responses, inflammation, and angiogenesis. Inducible
heme oxygenase-1 and downstream proteins biliverdin reductase
and p21, a cyclin-dependent kinase, were up-regulated, potentially
contributing to phenotypic heterogeneity and absence of atherosclerosis
in patients with sickle cell disease despite endothelial dysfunction
and vascular inflammation. Hydroxyurea therapy did not significantly
affect leukocyte gene expression, suggesting that such therapy
has limited direct anti-inflammatory activity beyond leukoreduction.
Global transcriptional analysis of circulating leukocytes highlights
the intense oxidant and inflammatory nature of steady-state sickle
cell disease and provides insight into the broad compensatory
responses to vascular injury. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15031206' target='EXTERNAL'>15031206</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>blood,Mononuclear,Sickle Cell,Middle Aged,Gene Expression Profiling,Oligonucleotide Array Sequence Analysis,Hemolysis,Comparative Study,Anemia,Oxidative Stress/physiology,Leukocytes,Flow Cytometry,genetics,Inflammation/blood,Cluster Analysis,metabolism,Male,Female,Humans,pathology,Heme Oxygenase (Decyclizing)/genetics/metabolism,cytology,Leukocyte Count,Cyclin-Dependent Kinases/genetics/metabolism,Case-Control Studies</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>HG_U95Av2</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='JISON_STRESS.grp'>grp</a>|<a href='JISON_STRESS.xml'>xml</a>|<a href='JISON_STRESS.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>32 genes, 33 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='4' class='fancy' border='0'><tr><th align='center'>Accession</th><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td width='75%'>36992_at</td><td>TXN</td><td>thioredoxin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TXN' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TXN' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>37468_at</td><td>JAK2</td><td>Janus kinase 2 (a protein tyrosine kinase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JAK2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JAK2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>40644_g_at</td><td>ITGA2B</td><td>integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITGA2B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITGA2B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>32860_g_at</td><td>STAT1</td><td>signal transducer and activator of transcription 1, 91kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=STAT1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?STAT1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>38281_at</td><td>CASP7</td><td>caspase 7, apoptosis-related cysteine protease</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CASP7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CASP7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>38435_at</td><td>PRDX4</td><td>peroxiredoxin 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PRDX4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PRDX4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>39436_at</td><td>BNIP3L</td><td>BCL2/adenovirus E1B 19kDa interacting protein 3-like</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BNIP3L' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BNIP3L' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>37002_at</td><td>BLVRB</td><td>biliverdin reductase B (flavin reductase (NADPH))</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BLVRB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BLVRB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>1457_at</td><td>JAK1</td><td>Janus kinase 1 (a protein tyrosine kinase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=JAK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?JAK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>37243_at</td><td>NA</td></tr><tr><td width='75%'>41776_at</td><td>ATOX1</td><td>ATX1 antioxidant protein 1 homolog (yeast)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ATOX1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ATOX1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>2000_at</td><td>ATM</td><td>ataxia telangiectasia mutated (includes complementation groups A, C and D)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ATM' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ATM' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>39425_at</td><td>TXNRD1</td><td>thioredoxin reductase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TXNRD1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TXNRD1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>41279_f_at</td><td>MAPK8IP1</td><td>mitogen-activated protein kinase 8 interacting protein 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAPK8IP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAPK8IP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>32716_at</td><td>DGKA</td><td>diacylglycerol kinase, alpha 80kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DGKA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DGKA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>37952_at</td><td>ITGB3</td><td>integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITGB3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITGB3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>40366_at</td><td>SELP</td><td>selectin P (granule membrane protein 140kDa, antigen CD62)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SELP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SELP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>38052_at</td><td>F13A1</td><td>coagulation factor XIII, A1 polypeptide</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=F13A1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?F13A1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>33802_at</td><td>HMOX1</td><td>heme oxygenase (decycling) 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HMOX1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HMOX1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>39822_s_at</td><td>GADD45B</td><td>growth arrest and DNA-damage-inducible, beta</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GADD45B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GADD45B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>37343_at</td><td>ITPR3</td><td>inositol 1,4,5-triphosphate receptor, type 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITPR3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITPR3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>37033_s_at</td><td>GPX1</td><td>glutathione peroxidase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GPX1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GPX1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>36879_at</td><td>ECGF1</td><td>endothelial cell growth factor 1 (platelet-derived)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ECGF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ECGF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>34777_at</td><td>ADM</td><td>adrenomedullin</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ADM' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ADM' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>34788_at</td><td>C9ORF132</td><td>chromosome 9 open reading frame 132</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=C9ORF132' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?C9ORF132' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>769_s_at</td><td>ANXA2 /// ANXA2P1 //</td><td>annexin A2 /// annexin A2 pseudogene 1 /// annexin A2 pseudogene 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ANXA2 /// ANXA2P1 //' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ANXA2 /// ANXA2P1 //' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>1233_s_at</td><td>AXL</td><td>AXL receptor tyrosine kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AXL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AXL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>2031_s_at</td><td>CDKN1A</td><td>cyclin-dependent kinase inhibitor 1A (p21, Cip1)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CDKN1A' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CDKN1A' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>32618_at</td><td>BLVRA</td><td>biliverdin reductase A</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BLVRA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BLVRA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>35872_at</td><td>PDE3B</td><td>phosphodiesterase 3B, cGMP-inhibited</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PDE3B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PDE3B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>822_s_at</td><td>CRADD</td><td>CASP2 and RIPK1 domain containing adaptor with death domain</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CRADD' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CRADD' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>38488_s_at</td><td>IL15</td><td>interleukin 15</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL15' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL15' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>824_at</td><td>GSTO1</td><td>glutathione S-transferase omega 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GSTO1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GSTO1' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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