[an error occurred while processing this directive]
<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: LOTEM_LEUKEMIA (C2:PERT:0075)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>LOTEM_LEUKEMIA</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0075</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes upregulated in myeloid leukemia and normally expressed in other bodily tissues.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><p><a onClick="switchAbstract('myvar_a');" title='Toggle abstract view'>Toggle abstract view</a><div id='myvar_a'><pre>Using DNA microarray and cluster analysis of expressed genes in
a cloned line (M1-t-p53) of myeloid leukemic cells, we have analyzed
the expression of genes that are preferentially expressed in different
normal tissues. Clustering of 547 highly expressed genes in these
leukemic cells showed 38 genes preferentially expressed in normal
hematopoietic tissues and 122 other genes preferentially expressed
in different normal nonhematopoietic tissues, including neuronal
tissues, muscle, liver, and testis. We have also analyzed the
genes whose expression in the leukemic cells changed after activation
of WT p53 and treatment with the cytokine IL-6 or the calcium
mobilizer thapsigargin. Of 620 such genes in the leukemic cells
that were differentially expressed in normal tissues, clustering
showed 80 genes that were preferentially expressed in hematopoietic
tissues and 132 genes in different normal nonhematopoietic tissues
that also included neuronal tissues, muscle, liver, and testis.
Activation of p53 and treatment with IL-6 or thapsigargin induced
different changes in the genes preferentially expressed in these
normal tissues. These myeloid leukemic cells thus express genes
that are expressed in normal nonhematopoietic tissues, and various
treatments can reprogram these cells to induce other such nonhematopoietic
genes. The results indicate that these leukemic cells share with
normal hematopoietic stem cells the plasticity of differentiation
to different cell types. It is suggested that this reprogramming
to induce in malignant cells genes that are expressed in different
normal tissues may be of clinical value in therapy. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15505217' target='EXTERNAL'>15505217</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Cell Line,Gene Expression/drug effects,Gene Expression Profiling,Oligonucleotide Array Sequence Analysis,Tumor Stem Cells/drug effects/metabolism/pathology,Myeloid,Interleukin-6/pharmacology,Leukemia,Genes,pathology,genetics,Mice,p53,Thapsigargin/pharmacology,Tissue Distribution,Cluster Analysis,Tumor</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Seq_Accession</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='LOTEM_LEUKEMIA.grp'>grp</a>|<a href='LOTEM_LEUKEMIA.xml'>xml</a>|<a href='LOTEM_LEUKEMIA.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>26 genes, 26 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='4' class='fancy' border='0'><tr><th align='center'>Accession</th><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td width='75%'>GTSE1</td><td>GTSE1</td><td>G-2 and S-phase expressed 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GTSE1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GTSE1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>ADCY7</td><td>ADCY7</td><td>adenylate cyclase 7</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ADCY7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ADCY7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>SNX10</td><td>SNX10</td><td>sorting nexin 10</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SNX10' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SNX10' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>CD53</td><td>CD53</td><td>CD53 antigen</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CD53' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CD53' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>SERPINI1</td><td>SERPINI1</td><td>serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SERPINI1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SERPINI1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>XMR</td></tr><tr><td width='75%'>NPHP1</td><td>NPHP1</td><td>nephronophthisis 1 (juvenile)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NPHP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NPHP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>PTPRO</td><td>PTPRO</td><td>protein tyrosine phosphatase, receptor type, O</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PTPRO' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PTPRO' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>CP</td><td>CP</td><td>ceruloplasmin (ferroxidase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>HCPH</td><td>PTPN6</td><td>protein tyrosine phosphatase, non-receptor type 6</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PTPN6' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PTPN6' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>PPM1B</td><td>PPM1B</td><td>protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PPM1B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PPM1B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>PMM1</td><td>PMM1</td><td>phosphomannomutase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PMM1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PMM1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>KPNA1</td><td>KPNA1</td><td>karyopherin alpha 1 (importin alpha 5)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=KPNA1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?KPNA1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>SC5D</td><td>SC5DL</td><td>sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SC5DL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SC5DL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>TAF9</td><td>TAF9</td><td>TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TAF9' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TAF9' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>IL4RA</td><td>IL4R</td><td>interleukin 4 receptor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL4R' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL4R' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>TCTE3</td><td>TCTE3</td><td>t-complex-associated-testis-expressed 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TCTE3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TCTE3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>CCS</td><td>CCS</td><td>copper chaperone for superoxide dismutase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCS' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCS' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>MLF1</td><td>MLF1</td><td>myeloid leukemia factor 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MLF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MLF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>LYPLA1</td><td>LYPLA1</td><td>lysophospholipase I</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LYPLA1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LYPLA1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AK1</td><td>AK1</td><td>adenylate kinase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AK1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AK1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>SH3GLB1</td><td>SH3GLB1</td><td>SH3-domain GRB2-like endophilin B1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SH3GLB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SH3GLB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>LIFR</td><td>LIFR</td><td>leukemia inhibitory factor receptor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LIFR' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LIFR' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>LPIN1</td><td>LPIN1</td><td>lipin 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LPIN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LPIN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>TAP1</td><td>TAP1</td><td>transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TAP1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TAP1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>EGR2</td><td>EGR2</td><td>early growth response 2 (Krox-20 homolog, Drosophila)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=EGR2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?EGR2' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
[an error occurred while processing this directive]