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Gene set: MLL_FUSION_ROSS (C2:PERT:0051)
Standard nameMLL_FUSION_ROSS
Systematic nameC2:PERT:0051
Brief descriptionGenes that distinguish pediatric acute myeloid leukemia (AML) subtypes with MLL chimeric fusion genes.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Contemporary treatment of pediatric acute myeloid leukemia (AML)
requires the assignment of patients to specific risk groups. To
explore whether expression profiling of leukemic blasts could
accurately distinguish between the known risk groups of AML, we
analyzed 130 pediatric and 20 adult AML diagnostic bone marrow
or peripheral blood samples using the Affymetrix U133A microarray.
Class discriminating genes were identified for each of the major
prognostic subtypes of pediatric AML, including t(15;17)[PML-RARalpha],
t(8;21)[AML1-ETO], inv(16) [CBFbeta-MYH11], MLL chimeric fusion
genes, and cases classified as FAB-M7. When subsets of these genes
were used in supervised learning algorithms, an overall classification
accuracy of more than 93% was achieved. Moreover, we were able
to use the expression signatures generated from the pediatric
samples to accurately classify adult de novo AMLs with the same
genetic lesions. The class discriminating genes also provided
novel insights into the molecular pathobiology of these leukemias.
Finally, using a combined pediatric data set of 130 AMLs and 137
acute lymphoblastic leukemias, we identified an expression signature
for cases with MLL chimeric fusion genes irrespective of lineage.
Surprisingly, AMLs containing partial tandem duplications of MLL
failed to cluster with MLL chimeric fusion gene cases, suggesting
a significant difference in their underlying mechanism of transformation.
Publication URL15226186
External linksna
Keywords & MeSH headingsTranscription Factors/genetics,Prognosis,Acute,Gene Expression Profiling,P.H.S.,classification,Oncogene Proteins,Proto-Oncogenes/genetics,Risk Factors,Blood,Fusion/genetics,Humans,Leukemia,genetics,Myelocytic,Child,DNA-Binding Proteins/genetics,Cluster Analysis,Algorithms,Tandem Repeat Sequences,Bone Marrow
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

82 genes, 100 accessions (Toggle view)

AccessionGeneTitleLinks
212174_atAK2adenylate kinase 2Source|GeneCards
202139_atAKR7A2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)Source|GeneCards
217861_s_atPREBprolactin regulatory element bindingSource|GeneCards
203372_s_atSOCS2suppressor of cytokine signaling 2Source|GeneCards
209199_s_atMEF2CMADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)Source|GeneCards
214196_s_atTPP1tripeptidyl peptidase ISource|GeneCards
205996_s_atAK2adenylate kinase 2Source|GeneCards
214651_s_atHOXA9homeo box A9Source|GeneCards
211067_s_atGAS7growth arrest-specific 7 /// growth arrest-specific 7Source|GeneCards
221666_s_atPYCARDPYD and CARD domain containingSource|GeneCards
218404_atSNX10sorting nexin 10Source|GeneCards
206050_s_atRNH1ribonuclease/angiogenin inhibitor 1Source|GeneCards
212173_atAK2adenylate kinase 2Source|GeneCards
218217_atSCPEP1serine carboxypeptidase 1Source|GeneCards
213908_atLOC339005 /// LOC440hypothetical protein LOC339005 /// hypothetical protein LOC440253Source|GeneCards
203373_atSOCS2suppressor of cytokine signaling 2Source|GeneCards
203562_atFEZ1fasciculation and elongation protein zeta 1 (zygin I)Source|GeneCards
219360_s_atTRPM4transient receptor potential cation channel, subfamily M, member 4Source|GeneCards
35974_atLRMPlymphoid-restricted membrane proteinSource|GeneCards
200782_atANXA5annexin A5Source|GeneCards
218262_atFLJ22318hypothetical protein FLJ22318Source|GeneCards
213915_atNKG7natural killer cell group 7 sequenceSource|GeneCards
218109_s_atMFSD1major facilitator superfamily domain containing 1Source|GeneCards
210549_s_atCCL23chemokine (C-C motif) ligand 23Source|GeneCards
208270_s_atRNPEParginyl aminopeptidase (aminopeptidase B)Source|GeneCards
204561_x_atAPOC2apolipoprotein C-IISource|GeneCards
204633_s_atRPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5Source|GeneCards
210548_atCCL23chemokine (C-C motif) ligand 23Source|GeneCards
218176_atMAGEF1melanoma antigen family F, 1Source|GeneCards
202087_s_atCTSLcathepsin LSource|GeneCards
220010_atKCNE1LKCNE1-likeSource|GeneCards
207968_s_atMEF2CMADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)Source|GeneCards
203909_atSLC9A6solute carrier family 9 (sodium/hydrogen exchanger), isoform 6Source|GeneCards
209663_s_atITGA7integrin, alpha 7Source|GeneCards
210184_atITGAXintegrin, alpha X (antigen CD11C (p150), alpha polypeptide)Source|GeneCards
209367_atSTXBP2syntaxin binding protein 2Source|GeneCards
205418_atFESfeline sarcoma oncogeneSource|GeneCards
210658_s_atGGA2golgi associated, gamma adaptin ear containing, ARF binding protein 2Source|GeneCards
204082_atPBX3pre-B-cell leukemia transcription factor 3Source|GeneCards
201859_atPRG1proteoglycan 1, secretory granuleSource|GeneCards
207614_s_atCUL1cullin 1Source|GeneCards
204674_atLRMPlymphoid-restricted membrane proteinSource|GeneCards
218376_s_atMICAL1microtubule associated monoxygenase, calponin and LIM domain containing 1Source|GeneCards
221726_atRPL22ribosomal protein L22Source|GeneCards
213361_atTDRD7tudor domain containing 7Source|GeneCards
212080_atMLLMyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
209439_s_atPHKA2phosphorylase kinase, alpha 2 (liver)Source|GeneCards
200742_s_atTPP1tripeptidyl peptidase ISource|GeneCards
203781_atMRPL33mitochondrial ribosomal protein L33Source|GeneCards
213844_atHOXA5homeo box A5Source|GeneCards
205936_s_atHK3hexokinase 3 (white cell)Source|GeneCards
214730_s_atGLG1golgi apparatus protein 1Source|GeneCards
216331_atITGA7integrin, alpha 7Source|GeneCards
201858_s_atPRG1proteoglycan 1, secretory granuleSource|GeneCards
204497_atADCY9adenylate cyclase 9Source|GeneCards
209093_s_atGBA /// GBAPglucosidase, beta; acid (includes glucosylceramidase) /// glucosidase, beta; acid, pseudogeneSource|GeneCards
208967_s_atAK2adenylate kinase 2Source|GeneCards
201003_x_atRNPEP /// UBE2V1 ///jugating enzyme E2 variant 1Source|GeneCards
221036_s_atAPH1Banterior pharynx defective 1 homolog B (C. elegans) /// anterior pharynx defective 1 homolog B (C. elegans)Source|GeneCards
203733_atDEXIdexamethasone-induced transcriptSource|GeneCards
201119_s_atCOX8Acytochrome c oxidase subunit 8A (ubiquitous)Source|GeneCards
207704_s_atGAS7growth arrest-specific 7Source|GeneCards
202605_atGUSBglucuronidase, betaSource|GeneCards
202054_s_atALDH3A2aldehyde dehydrogenase 3 family, member A2Source|GeneCards
201944_atHEXBhexosaminidase B (beta polypeptide)Source|GeneCards
202053_s_atALDH3A2aldehyde dehydrogenase 3 family, member A2Source|GeneCards
214259_s_atAKR7A2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)Source|GeneCards
213737_x_atLOC283768 /// LOC388 to hypothetical protein /// similar to hypothetical protein /// hypothetical protein DKFZp434P162Source|GeneCards
211004_s_atALDH3B1aldehyde dehydrogenase 3 family, member B1Source|GeneCards
214511_x_atFCGR1A /// LOC440607Fc fragment of IgG, high affinity Ia, receptor (CD64) /// Fc-gamma receptor I B2Source|GeneCards
203052_atC2complement component 2Source|GeneCards
1405_i_atCCL5chemokine (C-C motif) ligand 5Source|GeneCards
216950_s_atFCGR1AFc fragment of IgG, high affinity Ia, receptor (CD64)Source|GeneCards
206851_atRNASE3ribonuclease, RNase A family, 3 (eosinophil cationic protein)Source|GeneCards
202592_atBLOC1S1biogenesis of lysosome-related organelles complex-1, subunit 1Source|GeneCards
209616_s_atCES1carboxylesterase 1 (monocyte/macrophage serine esterase 1)Source|GeneCards
206100_atCPMcarboxypeptidase MSource|GeneCards
204174_atALOX5AParachidonate 5-lipoxygenase-activating proteinSource|GeneCards
201152_s_atMBNL1muscleblind-like (Drosophila)Source|GeneCards
204498_s_atADCY9adenylate cyclase 9Source|GeneCards
209696_atFBP1fructose-1,6-bisphosphatase 1Source|GeneCards
201105_atLGALS1lectin, galactoside-binding, soluble, 1 (galectin 1)Source|GeneCards
204655_atCCL5chemokine (C-C motif) ligand 5 /// chemokine (C-C motif) ligand 5Source|GeneCards
220793_atSAGE1sarcoma antigen 1Source|GeneCards
205613_atSYT17synaptotagmin XVIISource|GeneCards
202180_s_atMVPmajor vault proteinSource|GeneCards
221692_s_atMRPL34mitochondrial ribosomal protein L34 /// mitochondrial ribosomal protein L34Source|GeneCards
217520_x_atNA
205472_s_atDACH1dachshund homolog 1 (Drosophila)Source|GeneCards
201850_atCAPGcapping protein (actin filament), gelsolin-likeSource|GeneCards
206111_atRNASE2ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)Source|GeneCards
200886_s_atPGAM1phosphoglycerate mutase 1 (brain)Source|GeneCards
217827_s_atSPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)Source|GeneCards
213622_atCOL9A2collagen, type IX, alpha 2Source|GeneCards
220057_atXAGE1X antigen family, member 1Source|GeneCards
202897_atPTPNS1protein tyrosine phosphatase, non-receptor type substrate 1Source|GeneCards
205471_s_atDACH1dachshund homolog 1 (Drosophila)Source|GeneCards
212175_s_atAK2adenylate kinase 2Source|GeneCards
201050_atPLD3phospholipase D family, member 3Source|GeneCards
205859_atLY86lymphocyte antigen 86Source|GeneCards


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