[an error occurred while processing this directive]
Gene set: MOUSE_ACOX1_DOWN (C2:MODL:0012)
Standard nameMOUSE_ACOX1_DOWN
Systematic nameC2:MODL:0012
Brief descriptionGenes down-regulated in hepatoma tissue in Acox1 KO mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers. 
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

65 genes, 65 accessions (Toggle view)

GeneTitleLinks
MBL2mannose-binding lectin (protein C) 2, soluble (opsonic defect)Source|GeneCards
MYH1myosin, heavy polypeptide 1, skeletal muscle, adultSource|GeneCards
PRODHproline dehydrogenase (oxidase) 1Source|GeneCards
SLC29A1solute carrier family 29 (nucleoside transporters), member 1Source|GeneCards
BAATbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)Source|GeneCards
KHKketohexokinase (fructokinase)Source|GeneCards
SFTPDsurfactant, pulmonary-associated protein DSource|GeneCards
RNASE4ribonuclease, RNase A family, 4Source|GeneCards
MCM3APMCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated proteinSource|GeneCards
DPP4dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)Source|GeneCards
HGDhomogentisate 1,2-dioxygenase (homogentisate oxidase)Source|GeneCards
CA3carbonic anhydrase III, muscle specificSource|GeneCards
REPS1RALBP1 associated Eps domain containing 1Source|GeneCards
ORM1 /// ORM2orosomucoid 1 /// orosomucoid 2Source|GeneCards
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1Source|GeneCards
MASP1mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)Source|GeneCards
TNFRSF10Btumor necrosis factor receptor superfamily, member 10bSource|GeneCards
IL1RAPinterleukin 1 receptor accessory proteinSource|GeneCards
VPS11vacuolar protein sorting 11 (yeast)Source|GeneCards
APOC4apolipoprotein C-IVSource|GeneCards
SELENBP1selenium binding protein 1Source|GeneCards
AASSaminoadipate-semialdehyde synthaseSource|GeneCards
PIPOXpipecolic acid oxidaseSource|GeneCards
AKAP11A kinase (PRKA) anchor protein 11Source|GeneCards
TNNC2troponin C2, fastSource|GeneCards
HALhistidine ammonia-lyaseSource|GeneCards
SERPINA1serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Source|GeneCards
TPM2tropomyosin 2 (beta)Source|GeneCards
HSD11B1hydroxysteroid (11-beta) dehydrogenase 1Source|GeneCards
CPOXcoproporphyrinogen oxidaseSource|GeneCards
GSTA3glutathione S-transferase A3Source|GeneCards
EGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
ELA2elastase 2, neutrophilSource|GeneCards
HPD4-hydroxyphenylpyruvate dioxygenaseSource|GeneCards
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Source|GeneCards
ORM2orosomucoid 2Source|GeneCards
OATornithine aminotransferase (gyrate atrophy)Source|GeneCards
PAHphenylalanine hydroxylaseSource|GeneCards
SLC27A5solute carrier family 27 (fatty acid transporter), member 5Source|GeneCards
ETNK2ethanolamine kinase 2Source|GeneCards
LMCD1LIM and cysteine-rich domains 1Source|GeneCards
PHLDA1pleckstrin homology-like domain, family A, member 1Source|GeneCards
MCM10MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)Source|GeneCards
ITIH1inter-alpha (globulin) inhibitor, H1 polypeptideSource|GeneCards
TDO2tryptophan 2,3-dioxygenaseSource|GeneCards
GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)Source|GeneCards
C4BPAcomplement component 4 binding protein, alphaSource|GeneCards
SLC37A4solute carrier family 37 (glycerol-6-phosphate transporter), member 4Source|GeneCards
LIPClipase, hepaticSource|GeneCards
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)Source|GeneCards
PPP1R3Cprotein phosphatase 1, regulatory (inhibitor) subunit 3CSource|GeneCards
RGNregucalcin (senescence marker protein-30)Source|GeneCards
OTCornithine carbamoyltransferaseSource|GeneCards
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)Source|GeneCards
HBP1HMG-box transcription factor 1Source|GeneCards
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 1Source|GeneCards
TNNT3troponin T3, skeletal, fastSource|GeneCards
LECT2leukocyte cell-derived chemotaxin 2Source|GeneCards
CKMT2creatine kinase, mitochondrial 2 (sarcomeric)Source|GeneCards
CYP2F1cytochrome P450, family 2, subfamily F, polypeptide 1Source|GeneCards
G6PCglucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)Source|GeneCards
NINJ1ninjurin 1Source|GeneCards
SLCO2B1solute carrier organic anion transporter family, member 2B1Source|GeneCards
NR1H3nuclear receptor subfamily 1, group H, member 3Source|GeneCards
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 2Source|GeneCards


[an error occurred while processing this directive]