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Gene set: MOUSE_CIP_DOWN (C2:MODL:0014)
Standard nameMOUSE_CIP_DOWN
Systematic nameC2:MODL:0014
Brief descriptionGenes down-regulated in hepatoma induced by ciprofibrate
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers. 
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
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Genes

66 genes, 66 accessions (Toggle view)

GeneTitleLinks
MBL2mannose-binding lectin (protein C) 2, soluble (opsonic defect)Source|GeneCards
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 1Source|GeneCards
WNT10Bwingless-type MMTV integration site family, member 10BSource|GeneCards
GSTA4glutathione S-transferase A4Source|GeneCards
PRODHproline dehydrogenase (oxidase) 1Source|GeneCards
CMAHcytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase)Source|GeneCards
SLC17A3solute carrier family 17 (sodium phosphate), member 3Source|GeneCards
BAATbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)Source|GeneCards
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 1Source|GeneCards
NETO2neuropilin (NRP) and tolloid (TLL)-like 2Source|GeneCards
RNASE4ribonuclease, RNase A family, 4Source|GeneCards
PNLIPRP1pancreatic lipase-related protein 1Source|GeneCards
DPP4dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)Source|GeneCards
CA3carbonic anhydrase III, muscle specificSource|GeneCards
DMBT1deleted in malignant brain tumors 1Source|GeneCards
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1Source|GeneCards
TNFRSF10Btumor necrosis factor receptor superfamily, member 10bSource|GeneCards
IL1RAPinterleukin 1 receptor accessory proteinSource|GeneCards
KYNUkynureninase (L-kynurenine hydrolase)Source|GeneCards
CA5Acarbonic anhydrase VA, mitochondrialSource|GeneCards
SELENBP1selenium binding protein 1Source|GeneCards
PIPOXpipecolic acid oxidaseSource|GeneCards
ABAT4-aminobutyrate aminotransferaseSource|GeneCards
TNNC2troponin C2, fastSource|GeneCards
HALhistidine ammonia-lyaseSource|GeneCards
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2Source|GeneCards
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Source|GeneCards
HSD11B1hydroxysteroid (11-beta) dehydrogenase 1Source|GeneCards
REG1Aregenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)Source|GeneCards
EGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
PNLIPpancreatic lipaseSource|GeneCards
BCL6B-cell CLL/lymphoma 6 (zinc finger protein 51)Source|GeneCards
ELA2elastase 2, neutrophilSource|GeneCards
CTRCchymotrypsin C (caldecrin)Source|GeneCards
HPD4-hydroxyphenylpyruvate dioxygenaseSource|GeneCards
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Source|GeneCards
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2Source|GeneCards
OATornithine aminotransferase (gyrate atrophy)Source|GeneCards
TNNI2troponin I, skeletal, fastSource|GeneCards
PAHphenylalanine hydroxylaseSource|GeneCards
KRT4keratin 4Source|GeneCards
ETNK2ethanolamine kinase 2Source|GeneCards
MCM10MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)Source|GeneCards
ACADSBacyl-Coenzyme A dehydrogenase, short/branched chainSource|GeneCards
BHMTbetaine-homocysteine methyltransferaseSource|GeneCards
GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)Source|GeneCards
TRPV2transient receptor potential cation channel, subfamily V, member 2Source|GeneCards
KRT13keratin 13Source|GeneCards
MCM7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)Source|GeneCards
C4BPAcomplement component 4 binding protein, alphaSource|GeneCards
SLC37A4solute carrier family 37 (glycerol-6-phosphate transporter), member 4Source|GeneCards
SULT1B1sulfotransferase family, cytosolic, 1B, member 1Source|GeneCards
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2Source|GeneCards
PPP1R3Cprotein phosphatase 1, regulatory (inhibitor) subunit 3CSource|GeneCards
OTCornithine carbamoyltransferaseSource|GeneCards
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)Source|GeneCards
PON1paraoxonase 1Source|GeneCards
HBP1HMG-box transcription factor 1Source|GeneCards
TNNT3troponin T3, skeletal, fastSource|GeneCards
LECT2leukocyte cell-derived chemotaxin 2Source|GeneCards
EFNA4ephrin-A4Source|GeneCards
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2Source|GeneCards
CYP2F1cytochrome P450, family 2, subfamily F, polypeptide 1Source|GeneCards
G6PCglucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)Source|GeneCards
SERPINA6serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6Source|GeneCards
NR1H3nuclear receptor subfamily 1, group H, member 3Source|GeneCards


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