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Gene set: MOUSE_CIP_UP (C2:MODL:0013)
Standard nameMOUSE_CIP_UP
Systematic nameC2:MODL:0013
Brief descriptionGenes up-regulated in hepatoma induced by ciprofibrate
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers. 
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
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Genes

62 genes, 62 accessions (Toggle view)

GeneTitleLinks
CD36CD36 antigen (collagen type I receptor, thrombospondin receptor)Source|GeneCards
PLTPphospholipid transfer proteinSource|GeneCards
SLC16A1solute carrier family 16 (monocarboxylic acid transporters), member 1Source|GeneCards
ALDH3A2aldehyde dehydrogenase 3 family, member A2Source|GeneCards
RAD51L1RAD51-like 1 (S. cerevisiae)Source|GeneCards
VNN1vanin 1Source|GeneCards
HOXC6homeo box C6Source|GeneCards
APCSamyloid P component, serumSource|GeneCards
CTSEcathepsin ESource|GeneCards
MLYCDmalonyl-CoA decarboxylaseSource|GeneCards
COL4A2collagen, type IV, alpha 2Source|GeneCards
PMM1phosphomannomutase 1Source|GeneCards
CD24CD24 antigen (small cell lung carcinoma cluster 4 antigen)Source|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
BRCA1breast cancer 1, early onsetSource|GeneCards
TFF3trefoil factor 3 (intestinal)Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
KRT23keratin 23 (histone deacetylase inducible)Source|GeneCards
CHKBcholine kinase betaSource|GeneCards
SPRR1Asmall proline-rich protein 1ASource|GeneCards
CHKB /// CPT1Bcholine kinase beta /// carnitine palmitoyltransferase 1B (muscle)Source|GeneCards
FABP4fatty acid binding protein 4, adipocyteSource|GeneCards
NT5E5'-nucleotidase, ecto (CD73)Source|GeneCards
MYO5Cmyosin VCSource|GeneCards
UCP2uncoupling protein 2 (mitochondrial, proton carrier)Source|GeneCards
VNN3vanin 3Source|GeneCards
IGFBP2insulin-like growth factor binding protein 2, 36kDaSource|GeneCards
PEX11Aperoxisomal biogenesis factor 11ASource|GeneCards
C1ORF24chromosome 1 open reading frame 24Source|GeneCards
SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3Source|GeneCards
ABHD2abhydrolase domain containing 2Source|GeneCards
CIDEAcell death-inducing DFFA-like effector aSource|GeneCards
PDK4pyruvate dehydrogenase kinase, isoenzyme 4Source|GeneCards
GIPC2PDZ domain protein GIPC2Source|GeneCards
MFGE8milk fat globule-EGF factor 8 proteinSource|GeneCards
TM4SF4transmembrane 4 superfamily member 4Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Source|GeneCards
GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Source|GeneCards
CIDECcell death-inducing DFFA-like effector cSource|GeneCards
LEPRleptin receptorSource|GeneCards
EHHADHenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenaseSource|GeneCards
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)Source|GeneCards
SPON2spondin 2, extracellular matrix proteinSource|GeneCards
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
LY6Dlymphocyte antigen 6 complex, locus DSource|GeneCards
TEStestis derived transcript (3 LIM domains)Source|GeneCards
ADFPadipose differentiation-related proteinSource|GeneCards
S100A9S100 calcium binding protein A9 (calgranulin B)Source|GeneCards
COL4A1collagen, type IV, alpha 1Source|GeneCards
DAB1disabled homolog 1 (Drosophila)Source|GeneCards
BSGbasigin (OK blood group)Source|GeneCards
KIFAP3kinesin-associated protein 3Source|GeneCards
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 3Source|GeneCards
RAB30RAB30, member RAS oncogene familySource|GeneCards
MT2Ametallothionein 2ASource|GeneCards
NUP205nucleoporin 205kDaSource|GeneCards
QPCTglutaminyl-peptide cyclotransferase (glutaminyl cyclase)Source|GeneCards
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Source|GeneCards
LPLlipoprotein lipaseSource|GeneCards
C1ORF24chromosome 1 open reading frame 24Source|GeneCards


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